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Search Results to Brooke Fridley

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One or more keywords matched the following properties of Fridley, Brooke

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research overview Dr. Fridley joined Children’s Mercy in December of 2023 as the Director of the Biostatistics and Epidemiology Core within the Division of Health Services and Outcomes Research. She is also Professor of Pediatrics at the University of Missouri – Kansas City and is a member of the University of Kansas Cancer Center (KUCC). Before joining Children’s Mercy, she was the Chair of the Department of Biostatistics and Bioinformatics and Scientific Director for the CCSG Biostatistics and Bioinformatics Shared Resource at Moffitt Cancer Center in Tampa, FL. She has extensive experience as a collaborating biostatistician and has worked on numerous cancer research studies over the course of her career. These research collaborations have resulted in over 290 publications and 6 NIH grants for which she was Principal Investigator. She also has extensive experience mentoring trainees and was MPI of a T32 entitled “Integrative Program in Cancer and Data Science” from NIH/NCI. The Fridley lab is focused on development of novel statistical and bioinformatic methods to answer questions that arise in cancer research. Recently, her lab has been working on analytical methods for understanding the spatial architecture of the tumor immune microenvironment and how this is related to clinical outcomes by leveraging the information from spatial single-cell protein and spatial transcriptomic experiments.

One or more keywords matched the following items that are connected to Fridley, Brooke

Item TypeName
Concept Data Interpretation, Statistical
Concept Factor Analysis, Statistical
Concept Models, Statistical
Concept Genomics
Academic Article Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article Subject level clustering using a negative binomial model for small transcriptomic studies.
Academic Article A harmonized resource of integrated prostate cancer clinical, -omic, and signature features.
Academic Article Statistical Methods for Integrative Clustering of Multi-omics Data.
Academic Article Bayseian genomic models for the incorporation of pathway topology knowledge into association studies.
Academic Article Soft truncation thresholding for gene set analysis of RNA-seq data: application to a vaccine study.
Academic Article Integrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer.
Academic Article Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
Academic Article Methylation of leukocyte DNA and ovarian cancer: relationships with disease status and outcome.
Academic Article Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity.
Academic Article InterSIM: Simulation tool for multiple integrative 'omic datasets'.
Academic Article Genetic variations associated with gemcitabine treatment outcome in pancreatic cancer.
Academic Article Drug discovery using clinical outcome-based Connectivity Mapping: application to ovarian cancer.
Academic Article Mediation analysis of alcohol consumption, DNA methylation, and epithelial ovarian cancer.
Academic Article Statistical genomics in rare cancer.
Academic Article Nonlinear mixed-effects models for modeling in vitro drug response data to determine problematic cancer cell lines.
Academic Article Network-based integrative clustering of multiple types of genomic data using non-negative matrix factorization.
Academic Article Statistical and Bioinformatics Analysis of Data from Bulk and Single-Cell RNA Sequencing Experiments.
Academic Article Enabling Precision Medicine in Cancer Care Through a Molecular Data Warehouse: The Moffitt Experience.
Academic Article Challenges and Opportunities in the Statistical Analysis of Multiplex Immunofluorescence Data.
Academic Article Statistical analysis of single-cell protein data.
Academic Article Diagnostic tools in linkage analysis for quantitative traits.
Academic Article Imputation methods for missing data for polygenic models.
Academic Article Missing phenotype data imputation in pedigree data analysis.
Academic Article Model selection and Bayesian methods in statistical genetics: summary of group 11 contributions to Genetic Analysis Workshop 15.
Academic Article Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism.
Academic Article Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism.
Academic Article Human phenylethanolamine N-methyltransferase genetic polymorphisms and exercise-induced epinephrine release.
Academic Article Proteasome beta subunit pharmacogenomics: gene resequencing and functional genomics.
Academic Article Bayesian variable and model selection methods for genetic association studies.
Academic Article A Bayesian hierarchical nonlinear model for assessing the association between genetic variation and drug cytotoxicity.
Academic Article Conference Scene: Lessons learned from the 5th Statistical Analysis Workshop of the Pharmacogenetics Research Network.
Academic Article Bayesian mixture models for the incorporation of prior knowledge to inform genetic association studies.
Academic Article Gene set analysis of SNP data: benefits, challenges, and future directions.
Academic Article Gene set analysis of purine and pyrimidine antimetabolites cancer therapies.
Academic Article Gemcitabine metabolic pathway genetic polymorphisms and response in patients with non-small cell lung cancer.
Academic Article Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization.
Academic Article Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics.
Academic Article Genetic association studies of copy-number variation: should assignment of copy number states precede testing?
Academic Article A Bayesian integrative genomic model for pathway analysis of complex traits.
Academic Article Simultaneous analysis of multiple data types in pharmacogenomic studies using weighted sparse canonical correlation analysis.
Academic Article Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation.
Academic Article FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder.

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