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Search Results to Brooke Fridley

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One or more keywords matched the following properties of Fridley, Brooke

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research overview Dr. Fridley joined Children’s Mercy in December of 2023 as the Director of the Biostatistics and Epidemiology Core within the Division of Health Services and Outcomes Research. She is also Professor of Pediatrics at the University of Missouri – Kansas City and is a member of the University of Kansas Cancer Center (KUCC). Before joining Children’s Mercy, she was the Chair of the Department of Biostatistics and Bioinformatics and Scientific Director for the CCSG Biostatistics and Bioinformatics Shared Resource at Moffitt Cancer Center in Tampa, FL. She has extensive experience as a collaborating biostatistician and has worked on numerous cancer research studies over the course of her career. These research collaborations have resulted in over 290 publications and 6 NIH grants for which she was Principal Investigator. She also has extensive experience mentoring trainees and was MPI of a T32 entitled “Integrative Program in Cancer and Data Science” from NIH/NCI. The Fridley lab is focused on development of novel statistical and bioinformatic methods to answer questions that arise in cancer research. Recently, her lab has been working on analytical methods for understanding the spatial architecture of the tumor immune microenvironment and how this is related to clinical outcomes by leveraging the information from spatial single-cell protein and spatial transcriptomic experiments.

One or more keywords matched the following items that are connected to Fridley, Brooke

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Concept Hospitals, Pediatric
Concept Pharmacogenetics
Academic Article Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article Ontogeny Related Changes in the Pediatric Liver Metabolome.
Academic Article Integrating pharmacogenomic testing into paired germline and somatic genomic testing in patients with cancer.
Academic Article A phase I trial of metformin in combination with vincristine, irinotecan, and temozolomide in children with relapsed or refractory solid and central nervous system tumors: A report from the national pediatric cancer foundation.
Academic Article Contribution of FKBP5 genetic variation to gemcitabine treatment and survival in pancreatic adenocarcinoma.
Academic Article Integrative gene set analysis: application to platinum pharmacogenomics.
Academic Article Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes.
Academic Article Genetic variation in platinating agent and taxane pathway genes as predictors of outcome and toxicity in advanced non-small-cell lung cancer.
Academic Article Metformin pharmacogenomics: a genome-wide association study to identify genetic and epigenetic biomarkers involved in metformin anticancer response using human lymphoblastoid cell lines.
Academic Article An evolutionary framework for treating pediatric sarcomas.
Academic Article Phase II trial of gemcitabine and nab-paclitaxel in patients with recurrent Ewing sarcoma: A report from the National Pediatric Cancer Foundation.
Academic Article Clinical Trial Availability by Location for 1000 Simulated AYA Patients.
Academic Article Proteasome beta subunit pharmacogenomics: gene resequencing and functional genomics.
Academic Article Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.
Academic Article Methods for analysis in pharmacogenomics: lessons from the Pharmacogenetics Research Network Analysis Group.
Academic Article A Bayesian hierarchical nonlinear model for assessing the association between genetic variation and drug cytotoxicity.
Academic Article Gemcitabine and arabinosylcytosin pharmacogenomics: genome-wide association and drug response biomarkers.
Academic Article Conference Scene: Lessons learned from the 5th Statistical Analysis Workshop of the Pharmacogenetics Research Network.
Academic Article Localizing putative markers in genetic association studies by incorporating linkage disequilibrium into bayesian hierarchical models.
Academic Article Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.
Academic Article Multivariate models to detect genomic signatures for a class of drugs: application to thiopurines pharmacogenomics.
Academic Article Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics.
Academic Article Genetic association studies of copy-number variation: should assignment of copy number states precede testing?
Academic Article A Bayesian integrative genomic model for pathway analysis of complex traits.
Academic Article ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas.

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  • Pediatric
  • Pharmacogenetics