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Search Results to Brooke Fridley

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research overview Dr. Fridley joined Children’s Mercy in December of 2023 as the Director of the Biostatistics and Epidemiology Core within the Division of Health Services and Outcomes Research. She is also Professor of Pediatrics at the University of Missouri – Kansas City and is a member of the University of Kansas Cancer Center (KUCC). Before joining Children’s Mercy, she was the Chair of the Department of Biostatistics and Bioinformatics and Scientific Director for the CCSG Biostatistics and Bioinformatics Shared Resource at Moffitt Cancer Center in Tampa, FL. She has extensive experience as a collaborating biostatistician and has worked on numerous cancer research studies over the course of her career. These research collaborations have resulted in over 290 publications and 6 NIH grants for which she was Principal Investigator. She also has extensive experience mentoring trainees and was MPI of a T32 entitled “Integrative Program in Cancer and Data Science” from NIH/NCI. The Fridley lab is focused on development of novel statistical and bioinformatic methods to answer questions that arise in cancer research. Recently, her lab has been working on analytical methods for understanding the spatial architecture of the tumor immune microenvironment and how this is related to clinical outcomes by leveraging the information from spatial single-cell protein and spatial transcriptomic experiments.

One or more keywords matched the following items that are connected to Fridley, Brooke

Item TypeName
Concept Chromatography, High Pressure Liquid
Concept Predictive Value of Tests
Concept Reference Values
Concept Patient Protection and Affordable Care Act
Concept High-Throughput Nucleotide Sequencing
Academic Article Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article Pilot Study in Investigating Material Financial Toxicity Markers by Age in Cancer Patients.
Academic Article Soft truncation thresholding for gene set analysis of RNA-seq data: application to a vaccine study.
Academic Article Individualizing care for ovarian cancer patients using big data.
Academic Article Tumor hypomethylation at 6p21.3 associates with longer time to recurrence of high-grade serous epithelial ovarian cancer.
Academic Article Integrative clustering methods for high-dimensional molecular data.
Academic Article Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Postmenopausal Women.
Academic Article Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer.
Academic Article Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.
Academic Article Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Premenopausal Women.
Academic Article PPM1D Mosaic Truncating Variants in Ovarian Cancer Cases May Be Treatment-Related Somatic Mutations.
Academic Article Molecular classification of high grade endometrioid and clear cell ovarian cancer using TCGA gene expression signatures.
Academic Article Comprehensive Cross-Population Analysis of High-Grade Serous Ovarian Cancer Supports No More Than Three Subtypes.
Academic Article Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene.
Academic Article Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer.
Academic Article Genomic Analysis Using Regularized Regression in High-Grade Serous Ovarian Cancer.
Academic Article Sestrin family of genes and their role in cancer-related fatigue.
Academic Article Transcriptomic Characterization of Endometrioid, Clear Cell, and High-Grade Serous Epithelial Ovarian Carcinoma.
Academic Article Comparison of normalization approaches for gene expression studies completed with high-throughput sequencing.
Academic Article Lenalidomide-based response-adapted therapy for older adults without high risk myeloma.
Academic Article GMSimpute: a generalized two-step Lasso approach to impute missing values in label-free mass spectrum analysis.
Academic Article The prevalence of luminal B subtype is higher in older postmenopausal women with ER+/HER2- breast cancer and is associated with inferior outcomes.
Academic Article "I think that a brief conversation from their provider can go a very long way": Patient and provider perspectives on barriers and facilitators of genetic testing after ovarian cancer.
Academic Article Enabling Precision Medicine in Cancer Care Through a Molecular Data Warehouse: The Moffitt Experience.
Academic Article Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma.
Academic Article Impact of spatial clustering of cytotoxic and tumor infiltrating lymphocytes on overall survival in women with high grade serous ovarian cancer.
Academic Article Interacting alleles of the coinhibitory immunoreceptor genes cytotoxic T-lymphocyte antigen 4 and programmed cell-death 1 influence risk and features of primary biliary cirrhosis.
Academic Article Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism.
Academic Article Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism.
Academic Article Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study.
Academic Article Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking.
Academic Article A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation.
Academic Article ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium.
Academic Article Kernel canonical correlation analysis for assessing gene-gene interactions and application to ovarian cancer.
Academic Article Identification of novel variants in colorectal cancer families by high-throughput exome sequencing.
Academic Article PurBayes: estimating tumor cellularity and subclonality in next-generation sequencing data.

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