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Fridley, Brooke

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Dr. Fridley joined Children’s Mercy in December of 2023 as the Director of the Biostatistics and Epidemiology Core within the Division of Health Services and Outcomes Research. She is also Professor of Pediatrics at the University of Missouri – Kansas City and is a member of the University of Kansas Cancer Center (KUCC). Before joining Children’s Mercy, she was the Chair of the Department of Biostatistics and Bioinformatics and Scientific Director for the CCSG Biostatistics and Bioinformatics Shared Resource at Moffitt Cancer Center in Tampa, FL. She has extensive experience as a collaborating biostatistician and has worked on numerous cancer research studies over the course of her career. These research collaborations have resulted in over 290 publications and 6 NIH grants for which she was Principal Investigator. She also has extensive experience mentoring trainees and was MPI of a T32 entitled “Integrative Program in Cancer and Data Science” from NIH/NCI. The Fridley lab is focused on development of novel statistical and bioinformatic methods to answer questions that arise in cancer research. Recently, her lab has been working on analytical methods for understanding the spatial architecture of the tumor immune microenvironment and how this is related to clinical outcomes by leveraging the information from spatial single-cell protein and spatial transcriptomic experiments.

One or more keywords matched the following items that are connected to Fridley, Brooke

Item Type	Name
Concept	Data Collection
Concept	Data Interpretation, Statistical
Concept	Molecular Sequence Data
Concept	Databases, Factual
Concept	Databases, Genetic
Concept	Databases, Nucleic Acid
Concept	Datasets as Topic
Academic Article	Robust gene expression and mutation analyses of RNA-sequencing of formalin-fixed diagnostic tumor samples.
Academic Article	Assessment of data transformations for model-based clustering of RNA-Seq data.
Academic Article	Multi-omics Data Deconvolution and Integration: New Methods, Insights, and Translational Implications.
Academic Article	A Primer on Preprocessing, Visualization, Clustering, and Phenotyping of Barcode-Based Spatial Transcriptomics Data.
Academic Article	A harmonized resource of integrated prostate cancer clinical, -omic, and signature features.
Academic Article	Statistical Methods for Integrative Clustering of Multi-omics Data.
Academic Article	Bayseian genomic models for the incorporation of pathway topology knowledge into association studies.
Academic Article	Soft truncation thresholding for gene set analysis of RNA-seq data: application to a vaccine study.
Academic Article	Individualizing care for ovarian cancer patients using big data.
Academic Article	Integrative clustering methods for high-dimensional molecular data.
Academic Article	Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.
Academic Article	Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk.
Academic Article	Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer.
Academic Article	InterSIM: Simulation tool for multiple integrative 'omic datasets'.
Academic Article	PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
Academic Article	Comprehensive Cross-Population Analysis of High-Grade Serous Ovarian Cancer Supports No More Than Three Subtypes.
Academic Article	Drug discovery using clinical outcome-based Connectivity Mapping: application to ovarian cancer.
Academic Article	Integrative clustering of multi-level 'omic data based on non-negative matrix factorization algorithm.
Academic Article	A Curated Cancer Clinical Outcomes Database (C3OD) for accelerating patient recruitment in cancer clinical trials.
Academic Article	Nonlinear mixed-effects models for modeling in vitro drug response data to determine problematic cancer cell lines.
Academic Article	Network-based integrative clustering of multiple types of genomic data using non-negative matrix factorization.
Academic Article	Statistical and Bioinformatics Analysis of Data from Bulk and Single-Cell RNA Sequencing Experiments.
Academic Article	Enabling Precision Medicine in Cancer Care Through a Molecular Data Warehouse: The Moffitt Experience.
Academic Article	Challenges and Opportunities in the Statistical Analysis of Multiplex Immunofluorescence Data.
Academic Article	spatialTIME and iTIME: R package and Shiny application for visualization and analysis of immunofluorescence data.
Academic Article	A Question-and-Answer System to Extract Data From Free-Text Oncological Pathology Reports (CancerBERT Network): Development Study.
Academic Article	Statistical analysis of single-cell protein data.
Academic Article	Diagnostic tools in linkage analysis for quantitative traits.
Academic Article	Imputation methods for missing data for polygenic models.
Academic Article	Missing phenotype data imputation in pedigree data analysis.
Academic Article	Participation bias and its impact on the assembly of a genetic specimen repository for a myocardial infarction cohort.
Academic Article	Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism.
Academic Article	Comparison of variable and model selection methods for genetic association studies using the GAW15 simulated data.
Academic Article	Linkage analysis using principal components of gene expression data.
Academic Article	Proteasome beta subunit pharmacogenomics: gene resequencing and functional genomics.
Academic Article	Bayesian variable and model selection methods for genetic association studies.
Academic Article	A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.
Academic Article	Reproducibility of Genotypes as Measured by the Affymetrix GeneChip? 100K Human Mapping Array Set.
Academic Article	Single versus multiple imputation for genotypic data.
Academic Article	Utilizing genotype imputation for the augmentation of sequence data.
Academic Article	Self-contained gene-set analysis of expression data: an evaluation of existing and novel methods.
Academic Article	Gene set analysis of SNP data: benefits, challenges, and future directions.
Academic Article	Comparison of Penalty Functions for Sparse Canonical Correlation Analysis.
Academic Article	Use of the gamma method for self-contained gene-set analysis of SNP data.
Academic Article	Genetic association studies of copy-number variation: should assignment of copy number states precede testing?
Academic Article	European American stratification in ovarian cancer case control data: the utility of genome-wide data for inferring ancestry.
Academic Article	Genome-wide gene-set analysis for identification of pathways associated with alcohol dependence.
Academic Article	Simultaneous analysis of multiple data types in pharmacogenomic studies using weighted sparse canonical correlation analysis.
Academic Article	Identifying the genetic variation of gene expression using gene sets: application of novel gene Set eQTL approach to PharmGKB and KEGG.
Academic Article	TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression.
Academic Article	PurBayes: estimating tumor cellularity and subclonality in next-generation sequencing data.
Academic Article	mxfda: a comprehensive toolkit for functional data analysis of single-cell spatial data.
Academic Article	iModMix: Integrative Module Analysis for Multi-omics Data.
Academic Article	spatialGE is a User-Friendly Web Application that Facilitates Spatial Transcriptomics Data Analysis.

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