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Search Results to Vivekanand Yadav

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One or more keywords matched the following properties of Yadav, Vivekanand

keywords DIPG, DMG, Pediatric Brain Tumors, Genomic and Epigenetic Mechanism of Brain tumors
research overview Diffuse midline gliomas (DMGs) are the most aggressive pediatric high-grade gliomas and are the leading cause of cancer-related deaths in children. At present, there are no effective therapies for DMGs tumors, and over 90% of patients die within 1.5 years of diagnosis. In his lab, Dr. Yadav is leading efforts to understand genetic and epigenetic dependencies and signaling pathways that arise as a consequence of the H3K27M mutation in DMG. His lab performs pre-clinical studies using a novel in utero electroporation (IUE)-derived genetically engineered mouse model to identify promising candidates that can be targeted as therapy for the treatment of DMG. 1-Identifying genomic and epigenetic drivers of pediatric brain tumors with specific genetic alterations (H3K27M or H3G34R/V) using next-generation sequencing and a novel in utero electroporation (IUE) genetically engineered mouse model. 2-Developing more effective treatments by dissecting the resistance mechanisms of pediatric brain tumors using genome-wide CRISPR-based genetic screens.

One or more keywords matched the following items that are connected to Yadav, Vivekanand

Item TypeName
Concept Combined Modality Therapy
Concept Genetic Therapy
Concept Molecular Targeted Therapy
Academic Article Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma.
Academic Article Everolimus improves the efficacy of dasatinib in PDGFRa-driven glioma.
Academic Article Targeting and Therapeutic Monitoring of H3K27M-Mutant Glioma.
Academic Article Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas.
Academic Article Correction to: Targeting and Therapeutic Monitoring of H3K27M-Mutant Glioma.
Award or Honor Receipt Faculty award for basic science research
Academic Article Receptor tyrosine kinase (RTK) targeting in pediatric high-grade glioma and diffuse midline glioma: Pre-clinical models and precision medicine.
Academic Article Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma.
Academic Article Molecular ablation of tumor blood vessels inhibits therapeutic effects of radiation and bevacizumab.
Academic Article Single vs. combination immunotherapeutic strategies for glioma.
Academic Article Survival and Proliferation of Neural Progenitor-Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism.
Academic Article Mechanisms of glioma formation: iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and resistance to antiangiogenic therapy.
Academic Article There must be a way out of here: identifying a safe and efficient combination of promoter, transgene, and vector backbone for gene therapy of neurological disease.
Academic Article Neurotropic Viral Infections, Carol Shoshkes Reiss
Academic Article A road map for the treatment of pediatric diffuse midline glioma.

Search Criteria
  • Pediatric
  • Precision
  • Therapeutics