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Iwakuma, Tomoo

One or more keywords matched the following items that are connected to Iwakuma, Tomoo

Item Type	Name
Concept	Disease Models, Animal
Concept	Mice, Inbred C57BL
Concept	Mice, Mutant Strains
Concept	Mice, Nude
Concept	Mice, Transgenic
Concept	Models, Biological
Concept	Mice, SCID
Concept	Mice, Inbred NOD
Concept	Mice, Knockout
Concept	Mice, Congenic
Concept	Mice
Academic Article	Comparative oncology approach to drug repurposing in osteosarcoma.
Grant	The role of MDM2-MTBP axis in cancer metastasis
Academic Article	Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
Academic Article	Trp53 negatively regulates autoimmunity via the STAT3-Th17 axis.
Academic Article	Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.
Academic Article	IL-7Ra deficiency in p53null mice exacerbates thymocyte telomere erosion and lymphomagenesis.
Academic Article	MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4.
Academic Article	MDM2 binding protein, a novel metastasis suppressor.
Academic Article	Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.
Academic Article	MTBP inhibits migration and metastasis of hepatocellular carcinoma.
Academic Article	An improved intrafemoral injection with minimized leakage as an orthotopic mouse model of osteosarcoma.
Academic Article	Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities.
Academic Article	Suppression of pancreatic cancer growth and metastasis by HMP19 identified through genome-wide shRNA screen.
Academic Article	Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-?B and osteosarcoma progression.
Academic Article	Genome-wide in vivo RNAi screen identifies ITIH5 as a metastasis suppressor in pancreatic cancer.
Academic Article	Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase.
Academic Article	High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase.
Academic Article	[Study on carcinogenesis and mutation suppression: repair of alkylation DNA damage and suppression of tumors].
Academic Article	Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.
Academic Article	The Histone Demethylase KDM3A, Increased in Human Pancreatic Tumors, Regulates Expression of DCLK1 and Promotes Tumorigenesis in Mice.
Academic Article	Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice.
Academic Article	Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.
Academic Article	TAp63-miRNA-AURKA Axis as a Therapeutic Target for Cutaneous Squamous Cell Carcinoma.
Academic Article	Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
Academic Article	Li-Fraumeni syndrome: a p53 family affair.
Academic Article	Suppression of pancreatic cancer liver metastasis by secretion-deficient ITIH5.
Academic Article	Crippling p53 activities via knock-in mutations in mouse models.
Academic Article	Mutant p53 suppresses innate immune signaling to promote tumorigenesis.
Academic Article	Mtbp haploinsufficiency in mice increases tumor metastasis.
Academic Article	The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss.
Academic Article	Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy.
Academic Article	Mdm2 and Mdm4 loss regulates distinct p53 activities.
Academic Article	Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway.
Academic Article	Mutant p53 gain of oncogenic function: in vivo evidence, mechanism of action and its clinical implications.
Academic Article	A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis.
Academic Article	CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance.
Academic Article	A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.
Academic Article	DNAJA1 promotes cancer metastasis through interaction with mutant p53.
Academic Article	8-oxo-dGTP curbs tumor development via S phase arrest and AIF-mediated apoptosis.
Academic Article	Colonic L-cell impairment in aged subjects with type 2 diabetes leads to diminished GLP-1 production.

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