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Iwakuma, Tomoo

One or more keywords matched the following properties of Iwakuma, Tomoo

Property	Value
keywords	p53, MDM2, pediatric cancer, translational research
research overview	Dr. Iwakuma's primary research focuses on the field of Cancer Research, especially dissecting the mechanism of cancer progression and discovering novel drugs or compounds that specifically kill cancer cells, with special focus on the tumor suppressor p53 pathway.

One or more keywords matched the following items that are connected to Iwakuma, Tomoo

Item Type	Name
Concept	Bone Neoplasms
Concept	Breast Neoplasms
Concept	Carcinoma, Squamous Cell
Concept	Cell Adhesion
Concept	Cell Cycle
Concept	Cell Differentiation
Concept	Cell Line
Concept	Cell Movement
Concept	Cell Nucleus
Concept	Cell Separation
Concept	Cell Survival
Concept	Cell Transformation, Neoplastic
Concept	Cells, Cultured
Concept	HeLa Cells
Concept	Liver Neoplasms
Concept	Lung Neoplasms
Concept	Neoplasms
Concept	Neoplasms, Experimental
Concept	Pancreatic Neoplasms
Concept	Prostatic Neoplasms
Concept	Skin Neoplasms
Concept	Soft Tissue Neoplasms
Concept	Stem Cells
Concept	Stomach Neoplasms
Concept	Tumor Cells, Cultured
Concept	Neoplastic Stem Cells
Concept	Lymphoma, B-Cell
Concept	Cell Death
Concept	Neoplasms, Squamous Cell
Concept	Th1 Cells
Concept	Cell Cycle Proteins
Concept	Enteroendocrine Cells
Concept	NIH 3T3 Cells
Concept	HCT116 Cells
Concept	Cell Line, Tumor
Concept	Cell Growth Processes
Concept	Cell Proliferation
Concept	Th17 Cells
Concept	Cell Cycle Checkpoints
Concept	G1 Phase Cell Cycle Checkpoints
Academic Article	Comparative oncology approach to drug repurposing in osteosarcoma.
Grant	The role of MDM2-MTBP axis in cancer metastasis
Academic Article	Metastatic potential of tumor-initiating cells in solid tumors.
Academic Article	MTBP plays a crucial role in mitotic progression and chromosome segregation.
Academic Article	Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
Academic Article	Trp53 negatively regulates autoimmunity via the STAT3-Th17 axis.
Academic Article	IL-7Ra deficiency in p53null mice exacerbates thymocyte telomere erosion and lymphomagenesis.
Academic Article	MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4.
Academic Article	MDM2 binding protein, a novel metastasis suppressor.
Academic Article	A novel link between the HER2-Akt and MDM2-p53 pathways via CSN6.
Academic Article	Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.
Academic Article	Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing.
Academic Article	MTBP inhibits migration and metastasis of hepatocellular carcinoma.
Academic Article	An improved intrafemoral injection with minimized leakage as an orthotopic mouse model of osteosarcoma.
Academic Article	Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities.
Academic Article	Targeting Oncogenic Mutant p53 for Cancer Therapy.
Academic Article	Suppression of pancreatic cancer growth and metastasis by HMP19 identified through genome-wide shRNA screen.
Academic Article	DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway.
Academic Article	Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-?B and osteosarcoma progression.
Academic Article	Non-Canonical Cell Death Induced by p53.
Academic Article	p53 as a Regulator of Lipid Metabolism in Cancer.
Academic Article	Genome-wide in vivo RNAi screen identifies ITIH5 as a metastasis suppressor in pancreatic cancer.
Academic Article	Suppressive roles of A3AR and TMIGD3 i1 in osteosarcoma malignancy.
Academic Article	Unsaturated fatty acids regulate stemness of ovarian cancer cells through NF-?B.
Academic Article	Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma.
Academic Article	Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase.
Academic Article	Regulation of cytotoxic T-cell responses by p53 in cancer.
Academic Article	Murine double minute 2, a potential p53-independent regulator of liver cancer metastasis.
Academic Article	The interplay between mutant p53 and the mevalonate pathway.
Academic Article	Emerging Non-Canonical Functions and Regulation of p53.
Academic Article	RIPK1-TRAF2 interplay on the TNF/NF-?B signaling, cell death, and cancer development in the liver.
Academic Article	EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells.
Academic Article	Regulators of Oncogenic Mutant TP53 Gain of Function.
Academic Article	High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase.
Academic Article	[Study on carcinogenesis and mutation suppression: repair of alkylation DNA damage and suppression of tumors].
Academic Article	Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.
Academic Article	Self-inactivating lentiviral vectors with U3 and U5 modifications.
Academic Article	Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system.
Academic Article	TP53 in bone and soft tissue sarcomas.
Academic Article	The Histone Demethylase KDM3A, Increased in Human Pancreatic Tumors, Regulates Expression of DCLK1 and Promotes Tumorigenesis in Mice.
Academic Article	Suppressing STAT5 signaling affects osteosarcoma growth and stemness.
Academic Article	MDM2, an introduction.
Academic Article	Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.
Academic Article	TAp63-miRNA-AURKA Axis as a Therapeutic Target for Cutaneous Squamous Cell Carcinoma.
Academic Article	Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
Academic Article	Li-Fraumeni syndrome: a p53 family affair.
Academic Article	Suppression of pancreatic cancer liver metastasis by secretion-deficient ITIH5.
Academic Article	Crippling p53 activities via knock-in mutations in mouse models.
Academic Article	Mutant p53 suppresses innate immune signaling to promote tumorigenesis.
Academic Article	Mtbp haploinsufficiency in mice increases tumor metastasis.
Academic Article	The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss.
Academic Article	Mdm2 and Mdm4 loss regulates distinct p53 activities.
Academic Article	Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway.
Academic Article	A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis.
Academic Article	CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance.
Academic Article	A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.
Academic Article	DNAJA1 promotes cancer metastasis through interaction with mutant p53.
Academic Article	Regulation of p53 and Cancer Signaling by Heat Shock Protein 40/J-Domain Protein Family Members.
Academic Article	Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound Plumbagin.
Academic Article	DNAJA1- and conformational mutant p53-dependent inhibition of cancer cell migration by a novel compound identified through a virtual screen.
Academic Article	8-oxo-dGTP curbs tumor development via S phase arrest and AIF-mediated apoptosis.
Academic Article	Drugs Targeting p53 Mutations with FDA Approval and in Clinical Trials.
Academic Article	Perinucleolar Compartment (PNC) Prevalence as an Independent Prognostic Factor in Pediatric Ewing Sarcoma: A Multi-Institutional Study.
Academic Article	Characterization of an Mtbp Hypomorphic Allele in a Diethylnitrosamine-Induced Liver Carcinogenesis Model.
Academic Article	Colonic L-cell impairment in aged subjects with type 2 diabetes leads to diminished GLP-1 production.
Academic Article	A modified nucleoside O6-methyl-2'-deoxyguanosine-5'-triphosphate exhibits anti-glioblastoma activity in a caspase-independent manner.
Academic Article	Therapeutic potential of combating cancer by restoring wild-type p53 through mRNA nanodelivery.
Academic Article	Genes to Cells

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Cancer
Cell
Invasion