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Search Results to Tomoo Iwakuma

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One or more keywords matched the following properties of Iwakuma, Tomoo

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keywords p53, MDM2, pediatric cancer, translational research
research overview Dr. Iwakuma's primary research focuses on the field of Cancer Research, especially dissecting the mechanism of cancer progression and discovering novel drugs or compounds that specifically kill cancer cells, with special focus on the tumor suppressor p53 pathway.

One or more keywords matched the following items that are connected to Iwakuma, Tomoo

Item TypeName
Concept Bone Neoplasms
Concept Breast Neoplasms
Concept Liver Neoplasms
Concept Lung Neoplasms
Concept Neoplasms
Concept Neoplasms, Experimental
Concept Pancreatic Neoplasms
Concept Prostatic Neoplasms
Concept Skin Neoplasms
Concept Soft Tissue Neoplasms
Concept Stomach Neoplasms
Concept Neoplasms, Squamous Cell
Academic Article Comparative oncology approach to drug repurposing in osteosarcoma.
Grant The role of MDM2-MTBP axis in cancer metastasis
Grant Control of mutant p53 stability via the mevalonate pathway-DNAJA1 axis
Academic Article Metastatic potential of tumor-initiating cells in solid tumors.
Academic Article Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
Academic Article MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4.
Academic Article MDM2 binding protein, a novel metastasis suppressor.
Academic Article Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.
Academic Article MTBP inhibits migration and metastasis of hepatocellular carcinoma.
Academic Article An improved intrafemoral injection with minimized leakage as an orthotopic mouse model of osteosarcoma.
Academic Article Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities.
Academic Article Targeting Oncogenic Mutant p53 for Cancer Therapy.
Academic Article Suppression of pancreatic cancer growth and metastasis by HMP19 identified through genome-wide shRNA screen.
Academic Article Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-?B and osteosarcoma progression.
Academic Article p53 as a Regulator of Lipid Metabolism in Cancer.
Academic Article Genome-wide in vivo RNAi screen identifies ITIH5 as a metastasis suppressor in pancreatic cancer.
Academic Article Suppressive roles of A3AR and TMIGD3 i1 in osteosarcoma malignancy.
Academic Article Unsaturated fatty acids regulate stemness of ovarian cancer cells through NF-?B.
Academic Article Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma.
Academic Article Regulation of cytotoxic T-cell responses by p53 in cancer.
Academic Article Murine double minute 2, a potential p53-independent regulator of liver cancer metastasis.
Academic Article Emerging Non-Canonical Functions and Regulation of p53.
Academic Article RIPK1-TRAF2 interplay on the TNF/NF-?B signaling, cell death, and cancer development in the liver.
Academic Article Regulators of Oncogenic Mutant TP53 Gain of Function.
Academic Article High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase.
Academic Article [Study on carcinogenesis and mutation suppression: repair of alkylation DNA damage and suppression of tumors].
Academic Article Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.
Academic Article TP53 in bone and soft tissue sarcomas.
Academic Article The Histone Demethylase KDM3A, Increased in Human Pancreatic Tumors, Regulates Expression of DCLK1 and Promotes Tumorigenesis in Mice.
Academic Article Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase.
Academic Article MDM2, an introduction.
Academic Article Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.
Academic Article TAp63-miRNA-AURKA Axis as a Therapeutic Target for Cutaneous Squamous Cell Carcinoma.
Academic Article Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
Academic Article Suppression of pancreatic cancer liver metastasis by secretion-deficient ITIH5.
Academic Article Crippling p53 activities via knock-in mutations in mouse models.
Academic Article Mutant p53 suppresses innate immune signaling to promote tumorigenesis.
Academic Article Mtbp haploinsufficiency in mice increases tumor metastasis.
Academic Article The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss.
Academic Article Mdm2 and Mdm4 loss regulates distinct p53 activities.
Academic Article CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance.
Academic Article A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.
Academic Article DNAJA1 promotes cancer metastasis through interaction with mutant p53.
Academic Article Regulation of p53 and Cancer Signaling by Heat Shock Protein 40/J-Domain Protein Family Members.
Academic Article Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound Plumbagin.
Academic Article DNAJA1- and conformational mutant p53-dependent inhibition of cancer cell migration by a novel compound identified through a virtual screen.

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  • Cancer