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Cuna, Alain

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Genetic Predisposition to Disease

research overview

Dr. Cuna's main research interest is on defining the pathogenesis of necrotizing enterocolitis (NEC) – a devastating inflammatory bowel disease of preterm infants - and translating this knowledge to improve outcomes of NEC. His current focus is on understanding how host genetics and intestinal bacterial communities interact with each other to modulate inflammation in the developing neonatal gut. New knowledge gained from this research is anticipated to help in the development of personalized, microbial-based therapies based on underlying genetic predisposition and/or gut microbiome signatures to help maintain gut homeostasis. Such novel, individualized therapies are expected to drastically reduce the incidence of NEC in a safe and effective manner by targeting infants at highest risk of the disease.

One or more keywords matched the following items that are connected to Cuna, Alain

Item Type	Name
Concept	Chronic Disease
Concept	Disease Models, Animal
Concept	Infant, Newborn, Diseases
Concept	Infant, Premature, Diseases
Concept	Lung Diseases
Academic Article	Genetic alterations in necrotizing enterocolitis.
Academic Article	Single-Immunoglobulin Interleukin-1-Related Receptor regulates vulnerability to TLR4-mediated necrotizing enterocolitis in a mouse model.
Academic Article	Neonatal Graves' Disease with Maternal Hypothyroidism.
Academic Article	Bowel ultrasound for predicting surgical management of necrotizing enterocolitis: a systematic review and meta-analysis.
Academic Article	Genetic predisposition to necrotizing enterocolitis in premature infants: Current knowledge, challenges, and future directions.
Academic Article	Implementation of bowel ultrasound practice for the diagnosis and management of necrotising enterocolitis.
Academic Article	Integrated genomic analyses in bronchopulmonary dysplasia.
Academic Article	Regulation of alveolar septation by microRNA-489.
Grant	Gene-environment interactions in necrotizing enterocolitis: impact of SIGIRR mutation and gut microbiota on intestinal TLR hyperactivity
Academic Article	Dynamics of the preterm gut microbiome in health and disease.
Academic Article	Chronic lung disease in full-term infants: Characteristics and neonatal intensive care outcomes in infants referred to children's hospitals.
Academic Article	Feasibility and acceptability of a diagnostic randomized clinical trial of bowel ultrasound in infants with suspected necrotizing enterocolitis.
Academic Article	Necrotizing enterocolitis in premature infants-A defect in the brakes? Evidence from clinical and animal studies.

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Complex
diseases