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One or more keywords matched the following properties of Lane, Robert

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keywords Developmental Origins of Health and Disease
keywords Developmental Delay Disorder
research overview Dr. Lane’s research program focuses upon on how perinatal events affect in vivo epigenetic determinants of gene expression and lead to adult disease. In 1996, Dr. Lane published his first original science manuscript on this focus, and he has remained committed to the topic. Indeed, the vast majority of his > 90 publications are devoted to how perinatal events lead to adult disease. In 2003, Dr. Lane published his first original science manuscript on how perinatal events impact in vivo epigenetics. This study stands among the earliest to demonstrate that a perinatal event affected the epigenetics of a specific gene. Dr. Lane also has a track record of NIH funding as P.I. and a Co-I, the latter demonstrating his willingness to enthusiastically engage in team science. In 2013, Dr. Lane accepted the position of Pediatrician in Chief and Chair of Pediatrics at Children’s Hospital of Wisconsin. This move required Dr. Lane to move his laboratory. Yet, despite the move and the job requirements, Dr. Lane has maintained his scholarly productivity. In 2020, Dr. Lane accepted the position of Executive Vice President /Physician in Chief at Children’s Mercy in Kansas City. Dr. Lane has actively participated in the US Developmental Origins and Health and Disease Society. He has served as the scientific program officer for 2018 and 2019. In 2019, he was elected President of the Society. Dr. Lane’s laboratory has continued to be productive scientifically publishing papers in 2018 and 2019. Dr. Lane also chaired the NIH Social Epigenomics Study Section in 2020. His laboratory will move from Milwaukee to Kansas City in 6/2020 pending the impact of COVID-19.

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Concept Acetyl-CoA Carboxylase
Concept Mitochondrial ADP, ATP Translocases
Concept Cyclic AMP
Concept Alcohol Oxidoreductases
Concept Amino Acids, Branched-Chain
Concept Angiotensin II
Concept Animals, Newborn
Concept Aromatase
Concept Arsenic
Concept Base Sequence
Concept Bile Acids and Salts
Concept Binding Sites
Concept Blood Glucose
Concept Bone Development
Concept Calcium-Binding Proteins
Concept Carbon
Concept Carnitine O-Palmitoyltransferase
Concept Cholesterol
Concept Cholesterol 7-alpha-Hydroxylase
Concept Choline
Concept Chromatin
Concept Corticosterone
Concept Cotinine
Concept Creatinine
Concept Cystathionine beta-Synthase
Concept Dietary Fats
Concept DNA
Concept DNA Helicases
Concept DNA-Binding Proteins
Concept DNA, Mitochondrial
Concept Docosahexaenoic Acids
Concept Dose-Response Relationship, Drug
Concept Elastin
Concept Enzymes
Concept Epidermal Growth Factor
Concept Erythropoietin
Concept Estradiol
Concept Exons
Concept Fatty Acids
Concept Fatty Acids, Volatile
Concept Folic Acid
Concept Glial Fibrillary Acidic Protein
Concept Glucocorticoids
Concept Glucose
Concept Glucosephosphate Dehydrogenase
Concept Glycogen
Concept Proton-Translocating ATPases
Concept Heat-Shock Proteins
Concept Hexokinase
Concept Histone Deacetylases
Concept Histones
Concept Infant, Newborn
Concept Infant, Newborn, Diseases
Concept Insulin
Concept Insulin-Like Growth Factor I
Concept Iodide Peroxidase
Concept Ketone Oxidoreductases
Concept Lipids
Concept Lysine
Concept Malondialdehyde
Concept Malonyl Coenzyme A
Concept Methionine
Concept Methionine Adenosyltransferase
Concept Microfilament Proteins
Concept Monosaccharide Transport Proteins
Concept Multienzyme Complexes
Concept Muscle Proteins
Concept NAD
Concept NADH, NADPH Oxidoreductases
Concept Nerve Tissue Proteins
Concept Nicotine
Concept Nuclear Proteins
Concept Nucleosomes
Concept Oxidoreductases
Concept Oxygen
Concept Phospholipids
Concept Phosphoproteins
Concept Phosphopyruvate Hydratase
Concept Promoter Regions, Genetic
Concept Protein Kinases
Concept Histone-Lysine N-Methyltransferase
Concept Proto-Oncogene Proteins
Concept Receptors, Glucocorticoid
Concept Receptors, LDL
Concept Recombinant Proteins
Concept Respiratory Distress Syndrome, Newborn
Concept Rhodopsin
Concept RNA
Concept RNA Polymerase II
Concept RNA, Messenger
Concept S-Adenosylhomocysteine
Concept Serine
Concept Smoke
Concept Somatomedins
Concept Sucrose
Concept Testosterone
Concept Thromboxane A2
Concept Thyroid Hormones
Concept Transcription Factors
Concept Transferases
Concept Triglycerides
Concept Tumor Necrosis Factor-alpha
Concept Vasoconstrictor Agents
Concept Zinc
Concept 3-Hydroxyacyl CoA Dehydrogenases
Concept DNA Modification Methylases
Concept Antigens, CD
Concept Tumor Suppressor Protein p53
Concept Receptors, N-Methyl-D-Aspartate
Concept NF-kappa B
Concept Sp1 Transcription Factor
Concept Protein Tyrosine Phosphatases
Concept Alternative Splicing
Concept Isothiocyanates
Concept DNA Primers
Concept DNA, Complementary
Concept Receptors, Cytoplasmic and Nuclear
Concept Receptors, Mineralocorticoid
Concept Receptors, Retinoic Acid
Concept Gene Expression Regulation, Developmental
Concept Receptor, ErbB-2
Concept Proliferating Cell Nuclear Antigen
Concept CpG Islands
Concept Nitric Oxide Synthase
Concept Brain-Derived Neurotrophic Factor
Concept Proto-Oncogene Proteins c-bcl-2
Concept Human Growth Hormone
Concept Cyclin A
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Concept Leptin
Concept Neuregulin-1
Concept Tacrolimus Binding Proteins
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Concept Intercellular Signaling Peptides and Proteins
Concept Thyroid Hormone Receptors beta
Concept Vascular Endothelial Growth Factor Receptor-2
Concept Vascular Endothelial Growth Factor A
Concept 11-beta-Hydroxysteroid Dehydrogenases
Concept 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Concept Electron Transport Complex I
Concept 11-beta-Hydroxysteroid Dehydrogenase Type 2
Concept Parathyroid Hormone-Related Protein
Concept Fetal Development
Concept PPAR gamma
Concept Estrogen Receptor alpha
Concept Extracellular Signal-Regulated MAP Kinases
Concept STAT5 Transcription Factor
Concept p300-CBP Transcription Factors
Concept bcl-2-Associated X Protein
Concept Toll-Like Receptor 9
Concept Glucose Transporter Type 1
Concept Glucose Transporter Type 2
Concept Glucose Transporter Type 4
Concept Cyclooxygenase 2
Concept Proto-Oncogene Proteins c-mdm2
Concept Methyl-CpG-Binding Protein 2
Concept Basic Helix-Loop-Helix Transcription Factors
Concept Hypoxia-Inducible Factor 1, alpha Subunit
Concept Adiponectin
Concept Nitric Oxide Synthase Type III
Concept Caspase 3
Concept Adipokines
Concept Receptors, Adiponectin
Concept Dual-Specificity Phosphatases
Concept Dual Specificity Phosphatase 1
Concept Insulin Receptor Substrate Proteins
Concept Sirtuin 1
Concept Polyphenols
Concept RNA, Long Noncoding
Concept Nestin
Grant Maternal Diet Modifies the Fetal Primate Epigenome and Circadian Gene Expression
Grant PLACENTAL INSUFFICIENCY ALTERS MITOCHONDRIAL FUNCTION
Academic Article Measurement of GLUT mRNA in liver of fetal and neonatal rats using a novel method of quantitative polymerase chain reaction.
Academic Article Intrauterine growth retardation alters mitochondrial gene expression and function in fetal and juvenile rat skeletal muscle.
Academic Article Localization and quantification of glucose transporters in liver of growth-retarded fetal and neonatal rats.
Academic Article Placental expression of glucose transporter proteins 1 and 3 in growth-restricted fetal rats.
Academic Article Myocardial gene expression of glucose transporter 1 and glucose transporter 4 in response to uteroplacental insufficiency in the rat.
Academic Article Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney.
Academic Article Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats.
Academic Article Uteroplacental insufficiency decreases small intestine growth and alters apoptotic homeostasis in term intrauterine growth retarded rats.
Academic Article Nonresponsiveness of cerebral p53-MDM2 functional circuit in newborn rat pups rendered IUGR via uteroplacental insufficiency.
Academic Article Uteroplacental insufficiency alters hepatic expression, phosphorylation, and activity of the glucocorticoid receptor in fetal IUGR rats.
Academic Article Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats.
Academic Article Basic and translational research in neonatal pharmacology.
Academic Article Growth retardation alters the epigenetic characteristics of hepatic dual specificity phosphatase 5.
Academic Article Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension.
Academic Article Uteroplacental insufficiency decreases p53 serine-15 phosphorylation in term IUGR rat lungs.
Academic Article In utero tobacco exposure is associated with modified effects of maternal factors on fetal growth.
Academic Article Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome.
Academic Article Nasal ventilation alters mesenchymal cell turnover and improves alveolarization in preterm lambs.
Academic Article Programmed upregulation of adipogenic transcription factors in intrauterine growth-restricted offspring.
Academic Article Uteroplacental insufficiency affects kidney VEGF expression in a model of IUGR with compensatory glomerular hypertrophy and hypertension.
Academic Article Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene.
Academic Article The developmental origins of adult disease.
Academic Article A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome.
Academic Article Epigenetics and fetal adaptation to perinatal events: diversity through fidelity.
Academic Article Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth.
Academic Article Early and sustained increase in the expression of hippocampal IGF-1, but not EPO, in a developmental rodent model of traumatic brain injury.
Academic Article IUGR decreases PPAR? and SETD8 Expression in neonatal rat lung and these effects are ameliorated by maternal DHA supplementation.
Academic Article Mechanical-tactile stimulation (MTS) during neonatal stress prevents hyperinsulinemia despite stress-induced adiposity in weanling rat pups.
Academic Article Early postnatal nutrition and programming of the preterm neonate.
Academic Article IUGR decreases elastin mRNA expression in the developing rat lung and alters elastin content and lung compliance in the mature rat lung.
Academic Article IUGR differentially alters MeCP2 expression and H3K9Me3 of the PPAR? gene in male and female rat lungs during alveolarization.
Academic Article Intrauterine growth restriction alters T-lymphocyte cell number and dual specificity phosphatase 1 levels in the thymus of newborn and juvenile rats.
Academic Article Mechanism of reduced lung injury by high-frequency nasal ventilation in a preterm lamb model of neonatal chronic lung disease.
Academic Article Intrauterine growth restriction affects hippocampal dual specificity phosphatase 5 gene expression and epigenetic characteristics.
Academic Article Epigenetics and the developmental origins of lung disease.
Academic Article Mechanical-tactile stimulation (MTS) intervention in a neonatal stress model improves long-term outcomes on bone.
Academic Article Developmental traumatic brain injury decreased brain derived neurotrophic factor expression late after injury.
Academic Article Intrauterine growth restriction decreases endochondral ossification and bone strength in female rats.
Academic Article A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.
Academic Article Epigenetics and the developmental origins of disease: the key to unlocking the door of personalized medicine.
Academic Article Mechanical-tactile stimulation (MTS) intervention in a neonatal stress model alters adult adipose tissue deposition and prevents hyperinsulinemia in male rats.
Academic Article Epigenetic mechanisms in fetal origins of health and disease.
Academic Article Effects of oxygen on the development and severity of retinopathy of prematurity.
Academic Article Molecular determinants of lung development.
Academic Article Erythropoietin improved cognitive function and decreased hippocampal caspase activity in rat pups after traumatic brain injury.
Academic Article High-frequency nasal ventilation for 21 d maintains gas exchange with lower respiratory pressures and promotes alveolarization in preterm lambs.
Academic Article Fetal programming, epigenetics, and adult onset disease.
Academic Article Intrauterine growth restriction disrupts developmental epigenetics around distal growth hormone response elements on the rat hepatic IGF-1 gene.
Academic Article Epigenetic contributions to the developmental origins of adult lung disease.
Academic Article IUGR prevents IGF-1 upregulation in juvenile male mice by perturbing postnatal IGF-1 chromatin remodeling.
Academic Article IUGR increases chromatin-remodeling factor Brg1 expression and binding to GR exon 1.7 promoter in newborn male rat hippocampus.
Academic Article In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model.
Academic Article Programmed regulation of rat offspring adipogenic transcription factor (PPAR?) by maternal nutrition.
Academic Article Protective effect of maternal uteroplacental insufficiency on oxygen-induced retinopathy in offspring: removing bias of premature birth.
Academic Article Persistent pulmonary hypertension alters the epigenetic characteristics of endothelial nitric oxide synthase gene in pulmonary artery endothelial cells in a fetal lamb model.
Academic Article Adverse early-life environment impairs postnatal lung development in mice.
Academic Article Adverse maternal environment and western diet impairs cognitive function and alters hippocampal glucocorticoid receptor promoter methylation in male mice.
Academic Article Fetal growth restriction alters hippocampal 17-beta estradiol and estrogen receptor alpha levels in the newborn male rat.
Academic Article Adverse early life environment increases hippocampal microglia abundance in conjunction with decreased neural stem cells in juvenile mice.
Academic Article Adverse early life environment induces anxiety-like behavior and increases expression of FKBP5 mRNA splice variants in mouse brain.
Academic Article Mentoring and the development of the physician-scientist.
Award or Honor Receipt MRRC New Program Development Award
Award or Honor Receipt President
Award or Honor Receipt Co-Chair
Grant Developmental Nicotine Exposure and Transgenerationally Altered Lung Phenotype
Grant NPY Feeding Circuits During Development
Academic Article Hippocampal epigenetic and insulin-like growth factor alterations in noninvasive versus invasive mechanical ventilation in preterm lambs.

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