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Search Results to Robert H. Lane

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One or more keywords matched the following properties of Lane, Robert

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keywords Developmental Origins of Health and Disease
research overview Dr. Lane’s research program focuses upon on how perinatal events affect in vivo epigenetic determinants of gene expression and lead to adult disease. In 1996, Dr. Lane published his first original science manuscript on this focus, and he has remained committed to the topic. Indeed, the vast majority of his > 90 publications are devoted to how perinatal events lead to adult disease. In 2003, Dr. Lane published his first original science manuscript on how perinatal events impact in vivo epigenetics. This study stands among the earliest to demonstrate that a perinatal event affected the epigenetics of a specific gene. Dr. Lane also has a track record of NIH funding as P.I. and a Co-I, the latter demonstrating his willingness to enthusiastically engage in team science. In 2013, Dr. Lane accepted the position of Pediatrician in Chief and Chair of Pediatrics at Children’s Hospital of Wisconsin. This move required Dr. Lane to move his laboratory. Yet, despite the move and the job requirements, Dr. Lane has maintained his scholarly productivity. In 2020, Dr. Lane accepted the position of Executive Vice President /Physician in Chief at Children’s Mercy in Kansas City. Dr. Lane has actively participated in the US Developmental Origins and Health and Disease Society. He has served as the scientific program officer for 2018 and 2019. In 2019, he was elected President of the Society. Dr. Lane’s laboratory has continued to be productive scientifically publishing papers in 2018 and 2019. Dr. Lane also chaired the NIH Social Epigenomics Study Section in 2020. His laboratory will move from Milwaukee to Kansas City in 6/2020 pending the impact of COVID-19.

One or more keywords matched the following items that are connected to Lane, Robert

Item TypeName
Concept Fetal Blood
Concept Fetal Growth Retardation
Concept Health Services Needs and Demand
Concept Maternal-Fetal Exchange
Concept Quality Assurance, Health Care
Concept Maternal Exposure
Concept Rural Health Services
Concept Maternal Nutritional Physiological Phenomena
Concept Fetal Development
Concept Fetal Nutrition Disorders
Grant Uteroplacental Insufficiency Alters DNA Methylation
Grant Maternal Diet Modifies the Fetal Primate Epigenome and Circadian Gene Expression
Grant PLACENTAL INSUFFICIENCY ALTERS MITOCHONDRIAL FUNCTION
Academic Article Altered hepatic gene expression of enzymes involved in energy metabolism in the growth-retarded fetal rat.
Academic Article Measurement of GLUT mRNA in liver of fetal and neonatal rats using a novel method of quantitative polymerase chain reaction.
Academic Article Intrauterine growth retardation alters mitochondrial gene expression and function in fetal and juvenile rat skeletal muscle.
Academic Article Localization and quantification of glucose transporters in liver of growth-retarded fetal and neonatal rats.
Academic Article Placental expression of glucose transporter proteins 1 and 3 in growth-restricted fetal rats.
Academic Article Uteroplacental insufficiency alters cerebral mitochondrial gene expression and DNA in fetal and juvenile rats.
Academic Article Uteroplacental insufficiency alters hepatic fatty acid-metabolizing enzymes in juvenile and adult rats.
Academic Article Uteroplacental insufficiency lowers the threshold towards hypoxia-induced cerebral apoptosis in growth-retarded fetal rats.
Academic Article Myocardial gene expression of glucose transporter 1 and glucose transporter 4 in response to uteroplacental insufficiency in the rat.
Academic Article Altered expression and function of mitochondrial beta-oxidation enzymes in juvenile intrauterine-growth-retarded rat skeletal muscle.
Academic Article Uteroplacental insufficiency alters liver and skeletal muscle branched-chain amino acid metabolism in intrauterine growth-restricted fetal rats.
Academic Article Increased hepatic peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a rat model of intrauterine growth retardation and subsequent insulin resistance.
Academic Article IUGR alters postnatal rat skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a fiber specific manner.
Academic Article Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats.
Academic Article Uteroplacental insufficiency decreases small intestine growth and alters apoptotic homeostasis in term intrauterine growth retarded rats.
Academic Article Uteroplacental insufficiency induces site-specific changes in histone H3 covalent modifications and affects DNA-histone H3 positioning in day 0 IUGR rat liver.
Academic Article Nonresponsiveness of cerebral p53-MDM2 functional circuit in newborn rat pups rendered IUGR via uteroplacental insufficiency.
Academic Article Uteroplacental insufficiency alters hepatic expression, phosphorylation, and activity of the glucocorticoid receptor in fetal IUGR rats.
Academic Article Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats.
Academic Article Uteroplacental insufficiency increases p53 phosphorylation without triggering the p53-MDM2 functional circuit response in the IUGR rat kidney.
Academic Article Growth retardation alters the epigenetic characteristics of hepatic dual specificity phosphatase 5.
Academic Article Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension.
Academic Article Uteroplacental insufficiency decreases p53 serine-15 phosphorylation in term IUGR rat lungs.
Academic Article In utero tobacco exposure is associated with modified effects of maternal factors on fetal growth.
Academic Article Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome.
Academic Article Programmed upregulation of adipogenic transcription factors in intrauterine growth-restricted offspring.
Academic Article Intrauterine growth restriction due to uteroplacental insufficiency decreased white matter and altered NMDAR subunit composition in juvenile rat hippocampi.
Academic Article Uteroplacental insufficiency affects kidney VEGF expression in a model of IUGR with compensatory glomerular hypertrophy and hypertension.
Academic Article Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene.
Academic Article The developmental origins of adult disease.
Academic Article A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome.
Academic Article Epigenetics and fetal adaptation to perinatal events: diversity through fidelity.
Academic Article Uteroplacental insufficiency increases visceral adiposity and visceral adipose PPARgamma2 expression in male rat offspring prior to the onset of obesity.
Academic Article Intrauterine growth retardation affects expression and epigenetic characteristics of the rat hippocampal glucocorticoid receptor gene.
Academic Article Fetal growth restriction alters transcription factor binding and epigenetic mechanisms of renal 11beta-hydroxysteroid dehydrogenase type 2 in a sex-specific manner.
Academic Article Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth.
Academic Article IUGR decreases PPAR? and SETD8 Expression in neonatal rat lung and these effects are ameliorated by maternal DHA supplementation.
Academic Article IUGR decreases elastin mRNA expression in the developing rat lung and alters elastin content and lung compliance in the mature rat lung.
Academic Article IUGR differentially alters MeCP2 expression and H3K9Me3 of the PPAR? gene in male and female rat lungs during alveolarization.
Academic Article Intrauterine growth restriction alters T-lymphocyte cell number and dual specificity phosphatase 1 levels in the thymus of newborn and juvenile rats.
Academic Article Intrauterine growth restriction affects hippocampal dual specificity phosphatase 5 gene expression and epigenetic characteristics.
Academic Article Placental variability in methylation reflects maternal and fetal pathogenesis.
Academic Article Uteroplacental insufficiency alters rat hippocampal cellular phenotype in conjunction with ErbB receptor expression.
Academic Article Maternal Hyperglycemia Disrupts Histone 3 Lysine 36 Trimethylation of the IGF-1 Gene.
Academic Article Intrauterine growth restriction decreases endochondral ossification and bone strength in female rats.
Academic Article A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.
Academic Article Maternal high-fat diet modulates the fetal thyroid axis and thyroid gene expression in a nonhuman primate model.
Academic Article Intrauterine growth restriction transiently delays alveolar formation and disrupts retinoic acid receptor expression in the lung of female rat pups.
Academic Article Guidelines for surgeons on establishing projects in low-income countries.
Academic Article Maternal docosahexaenoic acid increases adiponectin and normalizes IUGR-induced changes in rat adipose deposition.
Academic Article Epigenetic mechanisms in fetal origins of health and disease.
Academic Article Maternal obesity and high-fat diet program offspring metabolic syndrome.
Academic Article Maternal tobacco smoke increased visceral adiposity and serum corticosterone levels in adult male rat offspring.
Academic Article Altered expression and chromatin structure of the hippocampal IGF1r gene is associated with impaired hippocampal function in the adult IUGR male rat.
Academic Article Combination of intrauterine growth restriction and a high-fat diet impairs cholesterol elimination in rats.
Academic Article Essential nutrient supplementation prevents heritable metabolic disease in multigenerational intrauterine growth-restricted rats.
Academic Article Fetal programming, epigenetics, and adult onset disease.
Academic Article Intrauterine growth restriction disrupts developmental epigenetics around distal growth hormone response elements on the rat hepatic IGF-1 gene.
Academic Article IUGR prevents IGF-1 upregulation in juvenile male mice by perturbing postnatal IGF-1 chromatin remodeling.
Academic Article IUGR increases chromatin-remodeling factor Brg1 expression and binding to GR exon 1.7 promoter in newborn male rat hippocampus.
Academic Article In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model.
Academic Article Programmed regulation of rat offspring adipogenic transcription factor (PPAR?) by maternal nutrition.
Academic Article Intrauterine growth restriction perturbs nucleosome depletion at a growth hormone-responsive element in the mouse IGF-1 gene.
Academic Article Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol and low-density lipoprotein receptor activity in rats.
Academic Article Protective effect of maternal uteroplacental insufficiency on oxygen-induced retinopathy in offspring: removing bias of premature birth.
Academic Article Persistent pulmonary hypertension alters the epigenetic characteristics of endothelial nitric oxide synthase gene in pulmonary artery endothelial cells in a fetal lamb model.
Academic Article Adverse maternal environment leads to cardiac fibrosis in adult male mice.
Academic Article Adverse early-life environment impairs postnatal lung development in mice.
Academic Article Adverse maternal environment and western diet impairs cognitive function and alters hippocampal glucocorticoid receptor promoter methylation in male mice.
Academic Article Intrauterine growth restriction alters hippocampal expression and chromatin structure of Cyp19a1 variants.
Academic Article Fetal growth restriction alters hippocampal 17-beta estradiol and estrogen receptor alpha levels in the newborn male rat.
Academic Article Predicting later-life outcomes of early-life exposures.
Award or Honor Receipt President
Grant Maternal High Fat Diet and Melanocortin System in Offspring
Grant Vitamin A Effects on Alveolar Formation in Preterm and Fetal Lambs with Chronic Lung Diseae
Grant IGF2 in Fetal Growth Restriction
Academic Article Adverse Maternal Environment Alters MicroRNA-10b-5p Expression and Its Epigenetic Profile Concurrently with Impaired Hippocampal Neurogenesis in Male Mouse Hippocampus
Academic Article Adverse Maternal Environment Alters MicroRNA-10b-5p Expression and Its Epigenetic Profile Concurrently with Impaired Hippocampal Neurogenesis in Male Mouse Hippocampus.
Academic Article Adverse Maternal Environment and Postweaning Western Diet Alter Hepatic CD36 Expression and Methylation Concurrently with Nonalcoholic Fatty Liver Disease in Mouse Offspring.
Academic Article Perinatal Research Society's Young Investigator Workshop Prepares the Next Generation of Investigators
Academic Article Adverse maternal environment affects hippocampal HTR2c variant expression and epigenetic characteristics in mouse offspring.

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