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One or more keywords matched the following properties of Lane, Robert

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keywords Developmental Origins of Health and Disease
keywords Developmental Delay Disorder
research overview Dr. Lane’s research program focuses upon on how perinatal events affect in vivo epigenetic determinants of gene expression and lead to adult disease. In 1996, Dr. Lane published his first original science manuscript on this focus, and he has remained committed to the topic. Indeed, the vast majority of his > 90 publications are devoted to how perinatal events lead to adult disease. In 2003, Dr. Lane published his first original science manuscript on how perinatal events impact in vivo epigenetics. This study stands among the earliest to demonstrate that a perinatal event affected the epigenetics of a specific gene. Dr. Lane also has a track record of NIH funding as P.I. and a Co-I, the latter demonstrating his willingness to enthusiastically engage in team science. In 2013, Dr. Lane accepted the position of Pediatrician in Chief and Chair of Pediatrics at Children’s Hospital of Wisconsin. This move required Dr. Lane to move his laboratory. Yet, despite the move and the job requirements, Dr. Lane has maintained his scholarly productivity. In 2020, Dr. Lane accepted the position of Executive Vice President /Physician in Chief at Children’s Mercy in Kansas City. Dr. Lane has actively participated in the US Developmental Origins and Health and Disease Society. He has served as the scientific program officer for 2018 and 2019. In 2019, he was elected President of the Society. Dr. Lane’s laboratory has continued to be productive scientifically publishing papers in 2018 and 2019. Dr. Lane also chaired the NIH Social Epigenomics Study Section in 2020. His laboratory will move from Milwaukee to Kansas City in 6/2020 pending the impact of COVID-19.

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Concept Dietary Fats
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Concept Docosahexaenoic Acids
Concept Dose-Response Relationship, Drug
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Grant Maternal Diet Modifies the Fetal Primate Epigenome and Circadian Gene Expression
Grant PLACENTAL INSUFFICIENCY ALTERS MITOCHONDRIAL FUNCTION
Academic Article Measurement of GLUT mRNA in liver of fetal and neonatal rats using a novel method of quantitative polymerase chain reaction.
Academic Article Intrauterine growth retardation alters mitochondrial gene expression and function in fetal and juvenile rat skeletal muscle.
Academic Article Placental expression of glucose transporter proteins 1 and 3 in growth-restricted fetal rats.
Academic Article Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney.
Academic Article Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats.
Academic Article Uteroplacental insufficiency decreases small intestine growth and alters apoptotic homeostasis in term intrauterine growth retarded rats.
Academic Article Uteroplacental insufficiency alters hepatic expression, phosphorylation, and activity of the glucocorticoid receptor in fetal IUGR rats.
Academic Article Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension.
Academic Article In utero tobacco exposure is associated with modified effects of maternal factors on fetal growth.
Academic Article Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome.
Academic Article Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene.
Academic Article The developmental origins of adult disease.
Academic Article A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome.
Academic Article Epigenetics and fetal adaptation to perinatal events: diversity through fidelity.
Academic Article Early and sustained increase in the expression of hippocampal IGF-1, but not EPO, in a developmental rodent model of traumatic brain injury.
Academic Article IUGR differentially alters MeCP2 expression and H3K9Me3 of the PPAR? gene in male and female rat lungs during alveolarization.
Academic Article Intrauterine growth restriction affects hippocampal dual specificity phosphatase 5 gene expression and epigenetic characteristics.
Academic Article Epigenetics and the developmental origins of lung disease.
Academic Article Mechanical-tactile stimulation (MTS) intervention in a neonatal stress model improves long-term outcomes on bone.
Academic Article Developmental traumatic brain injury decreased brain derived neurotrophic factor expression late after injury.
Academic Article Intrauterine growth restriction decreases endochondral ossification and bone strength in female rats.
Academic Article A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.
Academic Article Epigenetics and the developmental origins of disease: the key to unlocking the door of personalized medicine.
Academic Article Epigenetic mechanisms in fetal origins of health and disease.
Academic Article Effects of oxygen on the development and severity of retinopathy of prematurity.
Academic Article Molecular determinants of lung development.
Academic Article Erythropoietin improved cognitive function and decreased hippocampal caspase activity in rat pups after traumatic brain injury.
Academic Article Fetal programming, epigenetics, and adult onset disease.
Academic Article Intrauterine growth restriction disrupts developmental epigenetics around distal growth hormone response elements on the rat hepatic IGF-1 gene.
Academic Article Epigenetic contributions to the developmental origins of adult lung disease.
Academic Article IUGR prevents IGF-1 upregulation in juvenile male mice by perturbing postnatal IGF-1 chromatin remodeling.
Academic Article IUGR increases chromatin-remodeling factor Brg1 expression and binding to GR exon 1.7 promoter in newborn male rat hippocampus.
Academic Article In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model.
Academic Article Programmed regulation of rat offspring adipogenic transcription factor (PPAR?) by maternal nutrition.
Academic Article Persistent pulmonary hypertension alters the epigenetic characteristics of endothelial nitric oxide synthase gene in pulmonary artery endothelial cells in a fetal lamb model.
Academic Article Adverse early-life environment impairs postnatal lung development in mice.
Academic Article Adverse maternal environment and western diet impairs cognitive function and alters hippocampal glucocorticoid receptor promoter methylation in male mice.
Academic Article Mentoring and the development of the physician-scientist.
Award or Honor Receipt MRRC New Program Development Award
Award or Honor Receipt President
Award or Honor Receipt Co-Chair
Grant Developmental Nicotine Exposure and Transgenerationally Altered Lung Phenotype
Grant NPY Feeding Circuits During Development

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