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Search Results to Robert H. Lane

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One or more keywords matched the following properties of Lane, Robert

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keywords Developmental Origins of Health and Disease
keywords Developmental Delay Disorder
research overview Dr. Lane’s research program focuses upon on how perinatal events affect in vivo epigenetic determinants of gene expression and lead to adult disease. In 1996, Dr. Lane published his first original science manuscript on this focus, and he has remained committed to the topic. Indeed, the vast majority of his > 90 publications are devoted to how perinatal events lead to adult disease. In 2003, Dr. Lane published his first original science manuscript on how perinatal events impact in vivo epigenetics. This study stands among the earliest to demonstrate that a perinatal event affected the epigenetics of a specific gene. Dr. Lane also has a track record of NIH funding as P.I. and a Co-I, the latter demonstrating his willingness to enthusiastically engage in team science. In 2013, Dr. Lane accepted the position of Pediatrician in Chief and Chair of Pediatrics at Children’s Hospital of Wisconsin. This move required Dr. Lane to move his laboratory. Yet, despite the move and the job requirements, Dr. Lane has maintained his scholarly productivity. In 2020, Dr. Lane accepted the position of Executive Vice President /Physician in Chief at Children’s Mercy in Kansas City. Dr. Lane has actively participated in the US Developmental Origins and Health and Disease Society. He has served as the scientific program officer for 2018 and 2019. In 2019, he was elected President of the Society. Dr. Lane’s laboratory has continued to be productive scientifically publishing papers in 2018 and 2019. Dr. Lane also chaired the NIH Social Epigenomics Study Section in 2020. His laboratory will move from Milwaukee to Kansas City in 6/2020 pending the impact of COVID-19.

One or more keywords matched the following items that are connected to Lane, Robert

Item TypeName
Concept Alzheimer Disease
Concept Cardiovascular Diseases
Concept Chronic Disease
Concept Disease Models, Animal
Concept Disease Susceptibility
Concept Health Services Needs and Demand
Concept Infant, Newborn, Diseases
Concept Lung Diseases
Concept Metabolic Diseases
Concept Quality Assurance, Health Care
Concept Disease Progression
Concept Gene Expression Regulation, Developmental
Concept Rural Health Services
Concept Genetic Predisposition to Disease
Concept Disease Resistance
Concept Non-alcoholic Fatty Liver Disease
Grant Uteroplacental Insufficiency Alters DNA Methylation
Grant Maternal Diet Modifies the Fetal Primate Epigenome and Circadian Gene Expression
Grant PLACENTAL INSUFFICIENCY ALTERS MITOCHONDRIAL FUNCTION
Academic Article Measurement of GLUT mRNA in liver of fetal and neonatal rats using a novel method of quantitative polymerase chain reaction.
Academic Article Intrauterine growth retardation alters mitochondrial gene expression and function in fetal and juvenile rat skeletal muscle.
Academic Article Placental expression of glucose transporter proteins 1 and 3 in growth-restricted fetal rats.
Academic Article Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney.
Academic Article Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats.
Academic Article Uteroplacental insufficiency decreases small intestine growth and alters apoptotic homeostasis in term intrauterine growth retarded rats.
Academic Article Uteroplacental insufficiency alters hepatic expression, phosphorylation, and activity of the glucocorticoid receptor in fetal IUGR rats.
Academic Article Basic and translational research in neonatal pharmacology.
Academic Article Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension.
Academic Article Uteroplacental insufficiency decreases p53 serine-15 phosphorylation in term IUGR rat lungs.
Academic Article Gestational programming of offspring obesity: a potential contributor to Alzheimer's disease.
Academic Article Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome.
Academic Article Uteroplacental insufficiency affects kidney VEGF expression in a model of IUGR with compensatory glomerular hypertrophy and hypertension.
Academic Article Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene.
Academic Article The developmental origins of adult disease.
Academic Article Early and sustained increase in the expression of hippocampal IGF-1, but not EPO, in a developmental rodent model of traumatic brain injury.
Academic Article Early postnatal nutrition and programming of the preterm neonate.
Academic Article IUGR differentially alters MeCP2 expression and H3K9Me3 of the PPAR? gene in male and female rat lungs during alveolarization.
Academic Article Mechanism of reduced lung injury by high-frequency nasal ventilation in a preterm lamb model of neonatal chronic lung disease.
Academic Article Intrauterine growth restriction affects hippocampal dual specificity phosphatase 5 gene expression and epigenetic characteristics.
Academic Article Epigenetics and the developmental origins of lung disease.
Academic Article Mechanical-tactile stimulation (MTS) intervention in a neonatal stress model improves long-term outcomes on bone.
Academic Article Traumatic brain injury increased IGF-1B mRNA and altered IGF-1 exon 5 and promoter region epigenetic characteristics in the rat pup hippocampus.
Academic Article Developmental traumatic brain injury decreased brain derived neurotrophic factor expression late after injury.
Academic Article A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.
Academic Article Epigenetics and the developmental origins of disease: the key to unlocking the door of personalized medicine.
Academic Article Guidelines for surgeons on establishing projects in low-income countries.
Academic Article Epigenetic mechanisms in fetal origins of health and disease.
Academic Article Altered expression and chromatin structure of the hippocampal IGF1r gene is associated with impaired hippocampal function in the adult IUGR male rat.
Academic Article Combination of intrauterine growth restriction and a high-fat diet impairs cholesterol elimination in rats.
Academic Article Essential nutrient supplementation prevents heritable metabolic disease in multigenerational intrauterine growth-restricted rats.
Academic Article Fetal programming, epigenetics, and adult onset disease.
Academic Article Intrauterine growth restriction disrupts developmental epigenetics around distal growth hormone response elements on the rat hepatic IGF-1 gene.
Academic Article Epigenetic contributions to the developmental origins of adult lung disease.
Academic Article IUGR prevents IGF-1 upregulation in juvenile male mice by perturbing postnatal IGF-1 chromatin remodeling.
Academic Article IUGR increases chromatin-remodeling factor Brg1 expression and binding to GR exon 1.7 promoter in newborn male rat hippocampus.
Academic Article In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model.
Academic Article Programmed regulation of rat offspring adipogenic transcription factor (PPAR?) by maternal nutrition.
Academic Article The relationship between early-life environment, the epigenome and the microbiota.
Academic Article Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol and low-density lipoprotein receptor activity in rats.
Academic Article Protective effect of maternal uteroplacental insufficiency on oxygen-induced retinopathy in offspring: removing bias of premature birth.
Academic Article Persistent pulmonary hypertension alters the epigenetic characteristics of endothelial nitric oxide synthase gene in pulmonary artery endothelial cells in a fetal lamb model.
Academic Article Adverse maternal environment leads to cardiac fibrosis in adult male mice.
Academic Article Adverse early-life environment impairs postnatal lung development in mice.
Academic Article Adverse early life environment increases hippocampal microglia abundance in conjunction with decreased neural stem cells in juvenile mice.
Academic Article Predicting later-life outcomes of early-life exposures.
Award or Honor Receipt President
Grant Developmental Nicotine Exposure and Transgenerationally Altered Lung Phenotype
Academic Article Adverse Maternal Environment and Postweaning Western Diet Alter Hepatic CD36 Expression and Methylation Concurrently with Nonalcoholic Fatty Liver Disease in Mouse Offspring.
Academic Article Adverse Maternal Environments Perturb Hepatic DNA Methylome and Transcriptome Prior to the Adult-Onset Non-Alcoholic Fatty Liver Disease in Mouse Offspring.

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  • Origins
  • Health
  • Disease