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Sampath, Venkatesh

One or more keywords matched the following properties of Sampath, Venkatesh

Property	Value
keywords	Toll Like Receptor 4
keywords	Single Ig IL-1-related receptor (SIGIRR)
research overview	The focus of our program is to understand the “why” and “how” behind neonates developing diseases, with the ultimate goal of preventing or curing this patient population. We begin with disease phenotypes and investigate the pathogenic mechanisms underlying disease evolution to guide the development of novel future therapies. The phenotypes of interest to our program are necrotizing enterocolitis (NEC), Bronchopulmonary dysplasia (BPD), and rare infectious diseases such as Herpes Simplex virus (HSV), Group B Streptococcus (GBS), and SARS-CoV-2. Our program has adopted a “research without boundaries” approach, which integrates classical “basic”, “clinical” and “translational” strategies. We use human genomic studies, rodent disease models, in vitro studies, and bioinformatics to study mechanisms underlying disease pathogenesis, and testing therapeutic options. Our research vision aligns well with the goals of the CMRI to improve the health of children through multi-disciplinary research. The three major areas of our research focus include: Neonatal Diseases Research Program 1. Vascular remodeling and sub-phenotypes in BPD Investigate dysmorphic vascular arborization in the normal and abnormal lung (BPD). Genomic-Phenomic characterization of BPD sub-phenotypes. 2. Deviant host-pathogen crosstalk in NEC & sepsis Determine how genetic loci program deviant host-pathogen interactions underlying NEC and sepsis phenotypes in neonates. 3. Genomic-Phenomic characterization of neonatal disease susceptibility Discover genetic, phenomic, and transcriptomic signatures that underpin susceptibility to GBS, NEC, and HVS in neonates. Pillars of research program: The cornerstones of our program are phenotype-based research, emphasis on innovation and paradigm-shifting ideas, developing precision tools for phenotype characterization and therapeutics, and emphasis on training future generations of researchers. Accomplishments of our program: At a personal level, and as a research team we have had considerable success in terms of research publications, presentations, and awards at national/ international conferences, intramural and extramural NIH funding, and importantly in discovering and advancing science. A comprehensive list of our research achievements at Children’s Mercy Hospital over the last four years is presented in the subsequent pages. Long-term goal: Our long-term goal is to build an internationally renowned program in neonatal/perinatal research by integrating the skill sets of a diverse team of motivated scientists and collaborators. We will use the knowledge obtained through our investigations to develop precision tools for identifying infants at risk of disease and develop novel treatment strategies to prevent disease. These are commiserated with the CMRI and the NIH vision to promote research that advances the practice of personalized medicine. In subsequent sections, we will highlight the major accomplishments of our program. Support from the CMRI is critical for accomplishing our goals and will establish our program as an international center for research excellence in 5-7 years. Major Scientific Discoveries and Programmatic Accomplishments. 2a - Neonatal Lung Injury and Development: We investigate key modulators of lung endothelial/vascular development and lung injury using models relevant to bronchopulmonary dysplasia (BPD), the most common, debilitating lung disease in premature infants. Key discoveries include establishing a model of sepsis-induced lung remodeling, the discovery of the role of delta-like 4 (DLL4) as a novel regulator of lung vascular and epithelial development [front cover (JCI insights) and editorial (JCI)] and unearthing transcriptional regulation of lung endothelial inflammation [FOSL1 and FOXC2;]. Kindly see section 4 under manuscripts published for a reference list. More recently, we have developed, what I believe is one of the first systemic models for studying systemic SARS-CoV2-induced lung injury. 2b - Combining Genomics, Phenomics and Health Outcomes to Sub-classify BPD: We are pursuing exome sequencing to classify BPD sub-phenotypes in collaboration with the genome center [Drs. Pastinen and Dr. Smail]. In partnership with Drs. Manimtim and Akangire (Neonatology), we will use deep phenotyping and functional phenotyping on BPD infants to characterize BPD sub-phenotypes. Reconciling genetic with phenomic data will provide precision tools to characterize a complex disease and aid the development of phenotype-based approaches for BPD treatment. We have completed sequencing >900 preterm infants with and without BPD, making our study the largest exome study in preterm neonates to date. This maintains our leadership role in neonatal genomics. 2c - BPD therapeutics: More recently we have used our deep understanding on neonatal pathophysiology to probe new therapeutic options for BPD. In collaboration with Drs. Donald DeFranco [Professor & Vice Chair for Medical Education, UPMC], an expert in glucocorticoid signaling, and Dr. Paula Nichols [Professor, Associate Dean for Research, UMKC], we are performing basic and clinical studies on ciclesonide, a synthetic glucocorticoid, as a brain-sparing alternative to dexamethasone therapy for BPD. We have also initiated an industry partnership with COVIS Pharmaceuticals. We have just submitted an R21 application to fund a Phase 1 trial of ciclesonide in babies. 2d - Gene-Microbiota Interactions in NEC: Our focus is on understanding how host genetic variation interacts with developing gut microbiome to modulate the risk of necrotizing enterocolitis, a devastating gastrointestinal illness in preterm infants. Key contributions include identifying potential loci that modulate NEC susceptibility including SIGIRR and ATG16L1. Our research has led to a novel hypothesis for NEC i.e., genetic dysregulation of innate immune response underlies NEC pathogenesis. A major discovery identified SIGIRR regulates postnatal gut adaptation in neonatal mice, and loss of function mutations result in hypersensitivity to gut microbiota-induced inflammation [CMGH Front Cover and editorial]. 2e - NEC Genomics: Our lab has led the field of NEC Genomics with several publications. Recently, we have been analyzing the data from the first exome sequencing study in preterm NEC enrolling >900 infants. We hope to identify several loci that portend NEC vulnerability, laying the path for genetic screening to identifying infants at the highest risk of NEC. 2f - NEC therapeutics: Informed by the work of other investigators and our studies showing the efficacy of probiotics in NEC, we have successfully implemented probiotics to prevent NEC in the CMH-ICN in April 2021. This has resulted in a meaningful reduction in NEC in our infants. This reflects a direct bench-to-bedside translation of our work. We are also working on metabolites such as short-chain fatty acids as a bacteria-free preventive option for NEC. 2g - Genetics of rare neonatal infectious disease and undiagnosed lethal diseases: Our program has had a long-standing interest in severe neonatal Herpes Simplex infections and Group B streptococci. Our lab first discovered that severe neonatal HSV may have a genetic basis using a simple exome survey our ongoing work has identified IRF7 as a potential genetic loci for severe, recurrent neonatal HSV [accepted, Journal of Clinical Investigation]. Once this work is published, it is possibly one of the first human phenotypes for IRF7 mutations. Our ability to do functional studies for VUS has allowed us to identify genetic basis for rare, lethal disease, and return this information to parents for counseling. A recent illustration of this functional genomic work was done with colleagues in the genome center [EPHB4 mutation in neonatal hydrops, Pediatrics]. Programmatic accomplishments: The major accomplishment of our program apart from scientific discovery is establishing institutional, national, and international collaborations which have significantly elevated the status of our program, Neonatology, Pediatrics, and the CMRI nationally. This has resulted in bringing new research projects to Neonatology [NANO NICHD study, PI: Dr. Morowitz, UPMC], LEOPARD [multi-center BPD genomics study, PI: Dr. Hamvas, Northwestern University], and industry [partnership with COVIS is pending]. Our dedication to breaking “silos” has resulted in several fruitful collaborations. Some of these major collaborations are highlighted below. CMH collaborations a) CMKC-Neonatology: Dr. Sampath actively collaborates with the clinical bronchopulmonary dysplasia (BPD) program faculty including Drs. Manimtim and Akangire. Mentoring relationships are highlighted in a different section. b) CMKC – Genomics: Dr. Sampath has active collaborations with Drs. Pastinen, Farrow, Smail, Younger, and Grundberg for our rare and common disease genetic discovery program. c) CMKC – Infectious Disease: Dr. Sampath has an active collaboration with Dr. Susana Chavez Bueno. Our focus is on dissecting the host and bacterial factors determining neonatal E.Coli sepsis. d) CMKC – Allergy Immunology: Dr. Sampath has an active collaboration with Dr. Nikita Raje on understanding immunological basis of rare infectious diseases as well as T cell abnormalities and thymic hypoplasia in DeGeorge syndrome. e) CMKC – Dr. Lane’s lab: Dr. Sampath actively collaborates with Dr. Lane’s lab on the role of DLL4 in neonatal brain development/injury and epigenetic regulation of neonatal/perinatal pathology. Local collaborations a) Dr. Shahid Umar: We have a long-standing collaboration with Dr. Umar to investigate the emerging gut microbiota in the context of NEC and host genetics. b) Dr. Paula Nichols: We collaborate on the role of glucocorticoids signaling in neonatal lung and brain injury including testing new synthetic glucocorticoids with less brain toxicity. National and International Collaborations a) Genomics collaborations: We have active collaborations with several PI’s in institutions across the country. Prominent among those include Drs. Dagle (Iowa Children’s Hospital), Good (UNC, North Carolina), Patel (Emory, Atlanta), Underwood (UC Davis, California), Berrington (Newcastle, UK) and others. b) Genome-Microbiome Interactions: We collaborate with Dr. Morowitz (UPMC, Pittsburgh) as part of the NICHD-funded NANO clinical trial and a Pilot March of Dimes Grant. c) New steroid for preventing BPD in premature infants: We collaborate with Dr. DeFranco (UPMC) to examine the efficacy of ciclesonide, a brain-sparing synthetic glucocorticoid, in preventing neonatal lung injury without causing neuronal and myelination damage. d) Collaborations in lung vascular biology*: We collaborate with Dr. Ramchandran (MCW, Wisconsin) and Dr. Chen (MD Anderson, Texas) in lung biology. Partnership with industry (Pending) a) Ciclesonide clinical trial: We are in advanced negotiations with COVIS Pharmaceuticals to obtain funding to sponsor a pilot clinical trial of ciclesonide in preterm infants. Once the Phase 1 study is completed we plan to initiate a larger RCT.

One or more keywords matched the following items that are connected to Sampath, Venkatesh

Item Type	Name
Concept	Gastrointestinal Microbiome
Concept	Pyroptosis
Concept	Acidosis
Concept	Acute Disease
Concept	Anti-Infective Agents
Concept	Anti-Inflammatory Agents
Concept	Anti-Bacterial Agents
Concept	Antioxidants
Concept	Autophagy
Concept	Bilirubin
Concept	Birth Weight
Concept	Body Weight
Concept	Brain
Concept	Breast Feeding
Concept	Bronchopulmonary Dysplasia
Concept	Butyrates
Concept	C-Reactive Protein
Concept	Calcium-Binding Proteins
Concept	Cerebellum
Concept	Cerebral Cortex
Concept	Chromatography, High Pressure Liquid
Concept	Colitis
Concept	Colon
Concept	Complement C6
Concept	Complement C7
Concept	Diffusion of Innovation
Concept	Endotoxins
Concept	Enzyme-Linked Immunosorbent Assay
Concept	Escherichia coli
Concept	Fermentation
Concept	Hemodynamics
Concept	Humans
Concept	Ileum
Concept	Immunoglobulins
Concept	Interleukin-1
Concept	Intestinal Mucosa
Concept	Leukocytes, Mononuclear
Concept	Lipopolysaccharides
Concept	Longitudinal Studies
Concept	Mice, Inbred C3H
Concept	Mice, Inbred C57BL
Concept	Mice, Mutant Strains
Concept	Mice, Transgenic
Concept	Milk, Human
Concept	Organ Size
Concept	Oximetry
Concept	Oxygen
Concept	Patient Discharge
Concept	Phosphorylation
Concept	Promoter Regions, Genetic
Concept	Prospective Studies
Concept	Protein Processing, Post-Translational
Concept	Proteus mirabilis
Concept	Pulmonary Artery
Concept	Receptors, Glucocorticoid
Concept	Regeneration
Concept	Retrospective Studies
Concept	RNA, Ribosomal, 16S
Concept	Severity of Illness Index
Concept	Sheep
Concept	Superoxides
Concept	Transcription, Genetic
Concept	Tumor Necrosis Factor-alpha
Concept	Hydrops Fetalis
Concept	Cohort Studies
Concept	Signal Transduction
Concept	Biomarkers
Concept	Weight Gain
Concept	Up-Regulation
Concept	Intensive Care, Neonatal
Concept	Case-Control Studies
Concept	Interleukin-8
Concept	Bacteremia
Concept	Helicobacter pylori
Concept	Proto-Oncogene Proteins c-fos
Concept	Rats, Sprague-Dawley
Concept	Apoptosis
Concept	Receptors, Interleukin-1
Concept	Herpesvirus 1, Human
Concept	Mice, Knockout
Concept	Codon, Terminator
Concept	Intercellular Adhesion Molecule-1
Concept	Transcription Factor AP-1
Concept	Neovascularization, Physiologic
Concept	Chemokines
Concept	Chemokine CCL2
Concept	Tight Junctions
Concept	Endotoxemia
Concept	Mitogen-Activated Protein Kinase 1
Concept	Stroke
Concept	Polymorphism, Single Nucleotide
Concept	Encephalitis, Herpes Simplex
Concept	Asperger Syndrome
Concept	Protein Transport
Concept	Active Transport, Cell Nucleus
Concept	Genomics
Concept	Membrane Transport Proteins
Concept	RNA, Small Interfering
Concept	MicroRNAs
Concept	Receptor, EphB4
Concept	Infant Formula
Concept	Vascular Endothelial Growth Factor A
Concept	Angiopoietin-1
Concept	Angiopoietin-2
Concept	Receptor, TIE-2
Concept	Receptors, G-Protein-Coupled
Concept	Citrobacter rodentium
Concept	Biodiversity
Concept	HCT116 Cells
Concept	Cell Line, Tumor
Concept	TNF Receptor-Associated Factor 3
Concept	Mitogen-Activated Protein Kinase 3
Concept	Adaptor Proteins, Signal Transducing
Concept	STAT1 Transcription Factor
Concept	STAT3 Transcription Factor
Concept	Interferon Regulatory Factor-3
Concept	Scavenger Receptors, Class A
Concept	Frizzled Receptors
Concept	Toll-Like Receptors
Concept	Toll-Like Receptor 2
Concept	Toll-Like Receptor 3
Concept	Toll-Like Receptor 4
Concept	Toll-Like Receptor 5
Concept	Toll-Like Receptor 9
Concept	NF-E2-Related Factor 2
Concept	Mitochondrial Membranes
Concept	Mice
Concept	GRB2 Adaptor Protein
Concept	Rats
Concept	Receptors, Notch
Concept	Receptor, Notch1
Concept	NF-kappa B p50 Subunit
Concept	CARD Signaling Adaptor Proteins
Concept	Nod2 Signaling Adaptor Protein
Concept	Nod1 Signaling Adaptor Protein
Concept	Receptor-Interacting Protein Serine-Threonine Kinase 2
Concept	Matrix Metalloproteinase 12
Concept	Interleukin-1 Receptor-Associated Kinases
Concept	Myeloid Differentiation Factor 88
Concept	Host-Pathogen Interactions
Concept	Mucin-2
Concept	Young Adult
Concept	HEK293 Cells
Concept	Transcriptome
Concept	Wnt Signaling Pathway
Concept	Low Density Lipoprotein Receptor-Related Protein-6
Concept	Low Density Lipoprotein Receptor-Related Protein-5
Concept	Antioxidant Response Elements
Concept	Microbiota
Academic Article	Risk factors for adverse neurodevelopment in extremely low birth weight infants with normal neonatal cranial ultrasound.
Academic Article	Nonimmune hydrops fetalis and fulminant fatal disease due to congenital cytomegalovirus infection in a premature infant.
Academic Article	Altered postnatal lung development in C3H/HeJ mice.
Academic Article	Attenuation of lipopolysaccharide-induced oxidative stress and apoptosis in fetal pulmonary artery endothelial cells by hypoxia.
Academic Article	Lipopolysaccharide-induced cytokine expression in alveolar epithelial cells: role of PKC?-mediated p47phox phosphorylation.
Academic Article	The NFKB1 (g.-24519delATTG) variant is associated with necrotizing enterocolitis (NEC) in premature infants.
Academic Article	A TLR5 (g.1174C?>?T) variant that encodes a stop codon (R392X) is associated with bronchopulmonary dysplasia.
Academic Article	LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-? phosphorylation.
Academic Article	Antioxidant response genes sequence variants and BPD susceptibility in VLBW infants.
Academic Article	Lipopolysaccharide (LPS)-mediated angiopoietin-2-dependent autocrine angiogenesis is regulated by NADPH oxidase 2 (Nox2) in human pulmonary microvascular endothelial cells.
Academic Article	SIGIRR genetic variants in premature infants with necrotizing enterocolitis.
Academic Article	A toll-like receptor 9 (rs352140) variant is associated with placental inflammation in newborn infants.
Academic Article	Necrotizing Enterocolitis Is Not Associated With Sequence Variants in Antioxidant Response Genes in Premature Infants.
Academic Article	Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Regulates LPS-Induced Inflammation and Alveolar Remodeling in the Developing Lung.
Academic Article	Placental TLR/NLR expression signatures are altered with gestational age and inflammation.
Academic Article	Genetic alterations in necrotizing enterocolitis.
Academic Article	A functional ATG16L1 (T300A) variant is associated with necrotizing enterocolitis in premature infants.
Academic Article	Prospective Comparison of Enfamil and Similac Liquid Human Milk Fortifier on Clinical Outcomes in Premature Infants.
Academic Article	A Potential Role for the NOD1 Variant (rs6958571) in Gram-Positive Blood Stream Infection in ELBW Infants.
Academic Article	Single-Immunoglobulin Interleukin-1-Related Receptor regulates vulnerability to TLR4-mediated necrotizing enterocolitis in a mouse model.
Academic Article	Endothelial immune activation programmes cell-fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4-ERK-FOXC2 signalling.
Academic Article	DNMT and HDAC inhibitors together abrogate endotoxemia mediated macrophage death by STAT3-JMJD3 signaling.
Academic Article	Genetic predisposition to necrotizing enterocolitis in premature infants: Current knowledge, challenges, and future directions.
Academic Article	Enteric infection coupled with chronic Notch pathway inhibition alters colonic mucus composition leading to dysbiosis, barrier disruption and colitis.
Academic Article	Co-localization of autophagy-related protein p62 with cancer stem cell marker dclk1 may hamper dclk1's elimination during colon cancer development and progression.
Academic Article	Extended course of prednisolone in infants with severe bronchopulmonary dysplasia.
Academic Article	Histone deacetylase 6 regulates endothelial MyD88-dependent canonical TLR signaling, lung inflammation, and alveolar remodeling in the developing lung.
Grant	Single Immunoglobulin Interleukin-1 Related Receptor and necrotizing enterocolitis in premature infants
Grant	Lipopolysaccharide-mediated oxidative stress and pulmonary vascular injury in Bro
Grant	Inflammatory Angiogenesis in the Lung
Grant	Single Immunoglobulin Interleukin-l Related Receptor (SIGIRR) and Escherichia coli Interactions in the Neonatal Gut
Grant	Role of SIGIRR and Dysbiosis in Necrotizing Enterocolitis
Grant	Role of SIGIRR and Microbiome in regulating intestinal inflammation in NEC
Grant	SIGIRR mutations and pathogenesis of NEC in premature infants
Academic Article	Intrauterine fetal monitoring
Academic Article	Fungal cutaneous microbiome and host determinants in preterm and term neonates.
Academic Article	Infection-induced signals generated at the plasma membrane epigenetically regulate Wnt signaling in vitro and in vivo.
Academic Article	NEC-like intestinal injury is ameliorated by Lactobacillus rhamnosus GG in parallel with SIGIRR and A20 induction in neonatal mice.
Grant	The NICU Antibiotics and Neonatal Outcomes (NANO) trial
Academic Article	FOSL1 is a novel mediator of endotoxin/lipopolysaccharide-induced pulmonary angiogenic signaling.
Academic Article	Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods In Immune Support" Eds S. Chatterjee, W. Jungriathmyr and D. Bagchi
Academic Article	Impact of Maternal HbA1c Levels =6% and Race in Nondiabetic Pregnancies on Birthweight and Early Neonatal Hypoglycemia.
Academic Article	Challenges in diagnosing necrotizing enterocolitis.
Academic Article	Rare Genetic Variants in Immune Genes and Neonatal Herpes Simplex Viral Infections.
Academic Article	Intestinal Stem Cell Development in the Neonatal Gut: Pathways Regulating Development and Relevance to Necrotizing Enterocolitis.
Academic Article	Angiopoietin-1 protects against endotoxin-induced neonatal lung injury and alveolar simplification in mice.
Academic Article	Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum.
Academic Article	DCLK1 isoforms and aberrant Notch signaling in the regulation of human and murine colitis.
Academic Article	The Yin and the Yang of Transformative Research During the COVID-19 Pandemic-A Perspective.
Academic Article	SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut.
Academic Article	Postnatal Sepsis and Bronchopulmonary Dysplasia in Premature Infants: Mechanistic Insights into "New BPD".
Academic Article	Dietary Interventions Ameliorate Infectious Colitis by Restoring the Microbiome and Promoting Stem Cell Proliferation in Mice.
Academic Article	EPHB4 Mutation Suppresses PROX1 Expression and Disrupts Lymphatic Development in Neonatal Hydrops.
Academic Article	Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes.
Academic Article	Current Understanding of Transfusion-associated Necrotizing Enterocolitis: Review of Clinical and Experimental Studies and a Call for More Definitive Evidence.
Grant	A Safer Glucocorticoid to Treat Neonatal Lung Injury with Limited Adverse Neurologic Effects
Academic Article	Preterm sepsis is associated with acute lung injury as measured by pulmonary severity score.
Academic Article	Effect of Various Preterm Infant Milk Formulas on NEC-Like Gut Injury in Mice.
Academic Article	Adverse maternal environment alters Oprl1 variant expression in mouse hippocampus.
Academic Article	Short-chain fatty acids ameliorate necrotizing enterocolitis-like intestinal injury through enhancing Notch1-mediated single immunoglobulin interleukin-1-related receptor, toll-interacting protein, and A20 induction.
Academic Article	Necrotizing enterocolitis in premature infants-A defect in the brakes? Evidence from clinical and animal studies.
Academic Article	Early antibiotics and risk for necrotizing enterocolitis in premature infants: A narrative review.
Academic Article	The SARS-CoV-2 E protein induces Toll-like receptor 2-mediated neonatal lung injury in a model of COVID-19 viremia that is rescued by the glucocorticoid ciclesonide.
Academic Article	IRF7 and UNC93B1 variants in an infant with recurrent herpes simplex virus infection.
Academic Article	Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia-reperfusion injury.
Academic Article	The Detrimental Effects of Peripartum Antibiotics on Gut Proliferation and Formula Feeding Injury in Neonatal Mice Are Alleviated with Lactobacillus rhamnosus GG.
Academic Article	Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance.
Academic Article	HDAC6 and ERK/ADAM17 Regulate VEGF-Induced NOTCH Signaling in Lung Endothelial Cells.
Academic Article	Mechanisms of Endothelial Cell Membrane Repair: Progress and Perspectives.
Academic Article	Butyrate suppresses experimental necrotizing enterocolitis-induced brain injury in mice.
Academic Article	Triggered - does maternal COVID-19 program an exaggerated immune response in neonates?
Academic Article	Correction: Triggered - does maternal COVID-19 program an exaggerated immune response in neonates?
Academic Article	SARS-CoV-2 envelope protein regulates innate immune tolerance.
Academic Article	Delta like 4 regulates cerebrovascular development and endothelial integrity via DLL4-NOTCH-CLDN5 pathway and is vulnerable to neonatal hyperoxia.
Academic Article	The SafeBoosC-III trial and the future of cerebral oximetry-guided interventions in preterm infants-time to pause and reset?
Academic Article	Intestinal Crypt Apoptosis as an Orchestrator of Necrotizing Enterocolitis: A New Mechanism?
Academic Article	Insight Into Severe Neonatal COVID-19 Gained Through Whole Exome Sequencing of Twin Neonates.
Academic Article	Understanding necrotizing enterocolitis endotypes and acquired intestinal injury phenotypes from a historical and artificial intelligence perspective.
Academic Article	Lactobacillus rhamnosus modulates murine neonatal gut microbiota and inflammation caused by pathogenic Escherichia coli.
Academic Article	Physiologic and structural characterization of desisobutyryl-ciclesonide, a selective glucocorticoid receptor modulator in newborn rats.
Academic Article	The immunogenetic basis of severe herpes simplex infections in neonates and children: a review.

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SIGIRR