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Curran, Tom

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Signal Transduction

research overview

From 1984-1995, Dr. Curran worked at the Roche Institute of Molecular Biology ultimately rising to the position of Associate Director. He then founded the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital where he grew the Translational Brain Tumor Program over the period 1995-2006. He served as Deputy Scientific Director of the Children’s Hospital of Philadelphia Research Institute from 2006-2015 and he established the multi-institution Children’s Brain Tumor Tissue Consortium. Dr. Curran’s research spans the fields of cancer, signal transduction and neurobiology. He discovered and characterized the inducible Fos-Jun oncogenic transcription factor complex and demonstrated its function in diverse signal transduction processes. He also identified reelin, the gene responsible for the classic ataxic mouse mutation, reeler, and determined its role in the control of neuronal migration in the developing brain. Over the course of the last two decades, he pioneered the preclinical analysis of Hedgehog Pathway inhibitors for the treatment of pediatric medulloblastoma and transitioned this work into successful Phase I/II human clinical trials. His worked is published in over 300 papers that have been cited more than 74,000 times (Google Scholar). Dr. Curran was President of the American Association for Cancer Research (AACR) in 2000-2001 and he served on the National Cancer Institute Board of Scientific Advisors from 2000-2005. He was elected as a fellow of the American Association for the Advancement of Science (1994), the American Society of Microbiology (1994), the Royal Society, London (2005), the National Academy of Medicine (2009), the American Academy of Arts and Sciences (2012) and the Academy of the American Association for Cancer Research (2013). Dr. Curran has received several awards and honors including, the Passano Foundation Young Scientist Award in 1992, the Outstanding Achievement in Cancer Research award from the AACR in 1993, the Golgi Award from the Camillo Golgi Foundation and the Italian Academy of Neurosciences in 1994 and the Fred Epstein Lifetime Achievement Award from the Children's Brain Tumor Foundation in 2015. Many of his more than 50 trainees now hold senior positions in Academia and Industry.

One or more keywords matched the following items that are connected to Curran, Tom

Item Type	Name
Academic Article	Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer.
Academic Article	Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma.
Academic Article	Crk proteins transduce FGF signaling to promote lens fiber cell elongation.
Academic Article	CRK proteins selectively regulate T cell migration into inflamed tissues.
Academic Article	Dendritic planarity of Purkinje cells is independent of Reelin signaling.
Academic Article	Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis.
Academic Article	A gene expression approach to mapping the functional maturation of the hippocampus.
Academic Article	Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS.
Academic Article	The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.
Academic Article	Disabled-1 is expressed in type AII amacrine cells in the mouse retina.
Academic Article	Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1.
Academic Article	Role of the reelin signaling pathway in central nervous system development.
Academic Article	Disabled-1 interacts with a novel developmentally regulated protocadherin.
Academic Article	Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling.
Academic Article	ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease.
Academic Article	Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma.
Academic Article	Crystal structures of the Dab homology domains of mouse disabled 1 and 2.
Academic Article	Differential binding of ligands to the apolipoprotein E receptor 2.
Academic Article	Components of the reelin signaling pathway are expressed in the spinal cord.
Academic Article	Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.
Academic Article	Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics.
Academic Article	The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation.
Academic Article	The hedgehog pathway and neurological disorders.
Academic Article	Gene expression profiles of mouse retinas during the second and third postnatal weeks.
Academic Article	Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality.
Academic Article	Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.
Academic Article	Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling.
Academic Article	Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway.
Academic Article	c-fos and Signal Transduction In Vivo.
Academic Article	Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor.
Academic Article	The genetic landscape of the childhood cancer medulloblastoma.
Academic Article	PTHrP treatment fails to rescue bone defects caused by Hedgehog pathway inhibition in young mice.
Academic Article	The Hedgehog's tale: developing strategies for targeting cancer.
Academic Article	The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.
Academic Article	Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease.
Academic Article	Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity.
Academic Article	Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome.
Academic Article	The Ketogenic Diet Does Not Affect Growth of Hedgehog Pathway Medulloblastoma in Mice.
Academic Article	Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.
Academic Article	Crossed signals: oncogenic transcription factors.
Academic Article	Redox regulation of fos and jun DNA-binding activity in vitro.
Academic Article	Encounters with Fos and Jun on the road to AP-1.
Academic Article	Beyond the second messenger: oncogenes and transcription factors.
Academic Article	Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.
Academic Article	Spontaneous and evoked glutamate signalling influences Fos-lacZ expression and pyramidal cell death in hippocampal slice cultures from transgenic rats.
Academic Article	Redox regulation of AP-1: a link between transcription factor signaling and DNA repair.
Academic Article	Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain.
Academic Article	Leukotriene Synthesis Is Critical for Medulloblastoma Progression.
Academic Article	Statins repress hedgehog signaling in medulloblastoma with no bone toxicities.

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Signal Transduction