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Search Results to Tom Curran

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One or more keywords matched the following properties of Curran, Tom

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keywords Pediatrics
research overview From 1984-1995, Dr. Curran worked at the Roche Institute of Molecular Biology ultimately rising to the position of Associate Director. He then founded the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital where he grew the Translational Brain Tumor Program over the period 1995-2006. He served as Deputy Scientific Director of the Children’s Hospital of Philadelphia Research Institute from 2006-2015 and he established the multi-institution Children’s Brain Tumor Tissue Consortium. Dr. Curran’s research spans the fields of cancer, signal transduction and neurobiology. He discovered and characterized the inducible Fos-Jun oncogenic transcription factor complex and demonstrated its function in diverse signal transduction processes. He also identified reelin, the gene responsible for the classic ataxic mouse mutation, reeler, and determined its role in the control of neuronal migration in the developing brain. Over the course of the last two decades, he pioneered the preclinical analysis of Hedgehog Pathway inhibitors for the treatment of pediatric medulloblastoma and transitioned this work into successful Phase I/II human clinical trials. His worked is published in over 290 papers that have been cited more than 50,000 times. Dr. Curran was President of the American Association for Cancer Research (AACR) in 2000-2001 and he served on the National Cancer Institute Board of Scientific Advisors from 2000-2005. He was elected as a fellow of the American Association for the Advancement of Science (1994), the American Society of Microbiology (1994), the Royal Society, London (2005), the National Academy of Medicine (2009), the American Academy of Arts and Sciences (2012) and the Academy of the American Association for Cancer Research (2013). Dr. Curran has received several awards and honors including, the Passano Foundation Young Scientist Award in 1992, the Outstanding Achievement in Cancer Research award from the AACR in 1993, the Golgi Award from the Camillo Golgi Foundation and the Italian Academy of Neurosciences in 1994 and the Fred Epstein Lifetime Achievement Award from the Children's Brain Tumor Foundation in 2015. Many of his more than 50 trainees now hold senior positions in Academia and Industry.

One or more keywords matched the following items that are connected to Curran, Tom

Item TypeName
Concept Sarcoma Viruses, Murine
Concept Sarcoma
Concept Sarcoma, Experimental
Academic Article Patched2 modulates tumorigenesis in patched1 heterozygous mice.
Academic Article Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study.
Academic Article Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.
Academic Article Extended life span and tumorigenicity of nonestablished mouse connective tissue cells transformed by the fos oncogene of FBR-MuSV.
Academic Article Deletion of the gag region from FBR murine osteosarcoma virus does not affect its enhanced transforming activity.
Academic Article Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene.
Academic Article FBR murine osteosarcoma virus. I. Molecular analysis and characterization of a 75,000-Da gag-fos fusion product.
Academic Article FBR murine osteosarcoma virus. II. Nucleotide sequence of the provirus reveals that the genome contains sequences acquired from two cellular genes.
Academic Article Identification of a 39,000-dalton protein in cells transformed by the FBJ murine osteosarcoma virus.
Academic Article Candidate product of the FBJ murine osteosarcoma virus oncogene: characterization of a 55,000-dalton phosphoprotein.
Academic Article FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA.
Academic Article Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini.
Academic Article Structure of the FBJ murine osteosarcoma virus genome: molecular cloning of its associated helper virus and the cellular homolog of the v-fos gene from mouse and human cells.
Academic Article Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes.

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  • Pediatric
  • Sarcomas