Loading...
Keywords
Last Name
Institution

Connection

Search Results to Tom Curran

This is a "connection" page, showing the details of why an item matched the keywords from your search.

                     
                     

One or more keywords matched the following properties of Curran, Tom

PropertyValue
research overview From 1984-1995, Dr. Curran worked at the Roche Institute of Molecular Biology ultimately rising to the position of Associate Director. He then founded the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital where he grew the Translational Brain Tumor Program over the period 1995-2006. He served as Deputy Scientific Director of the Children’s Hospital of Philadelphia Research Institute from 2006-2015 and he established the multi-institution Children’s Brain Tumor Tissue Consortium. Dr. Curran’s research spans the fields of cancer, signal transduction and neurobiology. He discovered and characterized the inducible Fos-Jun oncogenic transcription factor complex and demonstrated its function in diverse signal transduction processes. He also identified reelin, the gene responsible for the classic ataxic mouse mutation, reeler, and determined its role in the control of neuronal migration in the developing brain. Over the course of the last two decades, he pioneered the preclinical analysis of Hedgehog Pathway inhibitors for the treatment of pediatric medulloblastoma and transitioned this work into successful Phase I/II human clinical trials. His worked is published in over 298 papers that have been cited more than 72,000 times (Google Scholar). Dr. Curran was President of the American Association for Cancer Research (AACR) in 2000-2001 and he served on the National Cancer Institute Board of Scientific Advisors from 2000-2005. He was elected as a fellow of the American Association for the Advancement of Science (1994), the American Society of Microbiology (1994), the Royal Society, London (2005), the National Academy of Medicine (2009), the American Academy of Arts and Sciences (2012) and the Academy of the American Association for Cancer Research (2013). Dr. Curran has received several awards and honors including, the Passano Foundation Young Scientist Award in 1992, the Outstanding Achievement in Cancer Research award from the AACR in 1993, the Golgi Award from the Camillo Golgi Foundation and the Italian Academy of Neurosciences in 1994 and the Fred Epstein Lifetime Achievement Award from the Children's Brain Tumor Foundation in 2015. Many of his more than 50 trainees now hold senior positions in Academia and Industry.

One or more keywords matched the following items that are connected to Curran, Tom

Item TypeName
Concept Gene Expression Regulation, Developmental
Concept Genes, Developmental
Academic Article Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse.
Academic Article Thyroid hormone regulates reelin and dab1 expression during brain development.
Academic Article Disabled-1 interacts with a novel developmentally regulated protocadherin.
Academic Article Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice.
Academic Article Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain.
Academic Article A neurogenomics approach to gene expression analysis in the developing brain.
Academic Article Developmental mouse brain gene expression maps.
Academic Article Gene expression profiles of mouse retinas during the second and third postnatal weeks.
Academic Article Developmental expression of thyroid hormone receptor beta2 protein in cone photoreceptors in the mouse.
Academic Article Reeler gene discrepancies.
Academic Article Isolation of an allele of reeler by insertional mutagenesis.
Academic Article Thyroid hormone receptor beta is essential for development of auditory function.
Academic Article Developmental expression of Fos-lacZ in the brains of postnatal transgenic rats.
Academic Article The human reelin gene: isolation, sequencing, and mapping on chromosome 7.
Academic Article Cerebellar disorganization characteristic of reeler in scrambler mutant mice despite presence of reelin.
Academic Article Role of reelin in the control of brain development.

Search Criteria
  • Developmental