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Search Results to Tom Curran

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research overview From 1984-1995, Dr. Curran worked at the Roche Institute of Molecular Biology ultimately rising to the position of Associate Director. He then founded the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital where he grew the Translational Brain Tumor Program over the period 1995-2006. He served as Deputy Scientific Director of the Children’s Hospital of Philadelphia Research Institute from 2006-2015 and he established the multi-institution Children’s Brain Tumor Tissue Consortium. Dr. Curran’s research spans the fields of cancer, signal transduction and neurobiology. He discovered and characterized the inducible Fos-Jun oncogenic transcription factor complex and demonstrated its function in diverse signal transduction processes. He also identified reelin, the gene responsible for the classic ataxic mouse mutation, reeler, and determined its role in the control of neuronal migration in the developing brain. Over the course of the last two decades, he pioneered the preclinical analysis of Hedgehog Pathway inhibitors for the treatment of pediatric medulloblastoma and transitioned this work into successful Phase I/II human clinical trials. His worked is published in over 298 papers that have been cited more than 72,000 times (Google Scholar). Dr. Curran was President of the American Association for Cancer Research (AACR) in 2000-2001 and he served on the National Cancer Institute Board of Scientific Advisors from 2000-2005. He was elected as a fellow of the American Association for the Advancement of Science (1994), the American Society of Microbiology (1994), the Royal Society, London (2005), the National Academy of Medicine (2009), the American Academy of Arts and Sciences (2012) and the Academy of the American Association for Cancer Research (2013). Dr. Curran has received several awards and honors including, the Passano Foundation Young Scientist Award in 1992, the Outstanding Achievement in Cancer Research award from the AACR in 1993, the Golgi Award from the Camillo Golgi Foundation and the Italian Academy of Neurosciences in 1994 and the Fred Epstein Lifetime Achievement Award from the Children's Brain Tumor Foundation in 2015. Many of his more than 50 trainees now hold senior positions in Academia and Industry.

One or more keywords matched the following items that are connected to Curran, Tom

Item TypeName
Concept Cost-Benefit Analysis
Concept DNA Mutational Analysis
Concept Survival Analysis
Concept Sequence Analysis, DNA
Concept Oligonucleotide Array Sequence Analysis
Concept Single-Cell Analysis
Academic Article Nestin Mediates Hedgehog Pathway Tumorigenesis.
Academic Article Prediction of central nervous system embryonal tumour outcome based on gene expression.
Academic Article A neurogenomics approach to gene expression analysis in the developing brain.
Academic Article A transcriptome map of cellular transformation by the fos oncogene.
Academic Article Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations.
Academic Article BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Academic Article Gene expression profiles of mouse retinas during the second and third postnatal weeks.
Academic Article The genetic landscape of the childhood cancer medulloblastoma.
Academic Article The Ketogenic Diet Does Not Affect Growth of Hedgehog Pathway Medulloblastoma in Mice.
Academic Article Whole-exome identifies RXRG and TH germline variants in familial isolated prolactinoma.
Academic Article Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts.
Academic Article Regulation of a fos-lacZ fusion gene: a paradigm for quantitative analysis of stimulus-transcription coupling.
Academic Article Analysis of dimerization and DNA binding functions in Fos and Jun by domain-swapping: involvement of residues outside the leucine zipper/basic region.
Academic Article Redox regulation of fos and jun DNA-binding activity in vitro.
Academic Article Analysis of Fos protein complexes and Fos-related antigens by high-resolution two-dimensional gel electrophoresis.
Academic Article Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro.
Academic Article FBR murine osteosarcoma virus. I. Molecular analysis and characterization of a 75,000-Da gag-fos fusion product.
Academic Article Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini.
Academic Article Viral and cellular fos proteins: a comparative analysis.
Academic Article The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.
Academic Article Analysis of c-Fos and c-Jun redox-dependent DNA binding activity.
Academic Article Design of a "minimAl" homeodomain: the N-terminal arm modulates DNA binding affinity and stabilizes homeodomain structure.
Academic Article A central role for Fos in human B- and T-cell NFAT (nuclear factor of activated T cells): an acidic region is required for in vitro assembly.
Academic Article Energy transfer analysis of Fos-Jun dimerization and DNA binding.
Academic Article Genetic analysis of thyroid hormone receptors in development and disease.
Academic Article Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality.
Academic Article Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes.

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