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research overview From 1984-1995, Dr. Curran worked at the Roche Institute of Molecular Biology ultimately rising to the position of Associate Director. He then founded the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital where he grew the Translational Brain Tumor Program over the period 1995-2006. He served as Deputy Scientific Director of the Children’s Hospital of Philadelphia Research Institute from 2006-2015 and he established the multi-institution Children’s Brain Tumor Tissue Consortium. Dr. Curran’s research spans the fields of cancer, signal transduction and neurobiology. He discovered and characterized the inducible Fos-Jun oncogenic transcription factor complex and demonstrated its function in diverse signal transduction processes. He also identified reelin, the gene responsible for the classic ataxic mouse mutation, reeler, and determined its role in the control of neuronal migration in the developing brain. Over the course of the last two decades, he pioneered the preclinical analysis of Hedgehog Pathway inhibitors for the treatment of pediatric medulloblastoma and transitioned this work into successful Phase I/II human clinical trials. His worked is published in over 298 papers that have been cited more than 72,000 times (Google Scholar). Dr. Curran was President of the American Association for Cancer Research (AACR) in 2000-2001 and he served on the National Cancer Institute Board of Scientific Advisors from 2000-2005. He was elected as a fellow of the American Association for the Advancement of Science (1994), the American Society of Microbiology (1994), the Royal Society, London (2005), the National Academy of Medicine (2009), the American Academy of Arts and Sciences (2012) and the Academy of the American Association for Cancer Research (2013). Dr. Curran has received several awards and honors including, the Passano Foundation Young Scientist Award in 1992, the Outstanding Achievement in Cancer Research award from the AACR in 1993, the Golgi Award from the Camillo Golgi Foundation and the Italian Academy of Neurosciences in 1994 and the Fred Epstein Lifetime Achievement Award from the Children's Brain Tumor Foundation in 2015. Many of his more than 50 trainees now hold senior positions in Academia and Industry.

One or more keywords matched the following items that are connected to Curran, Tom

Item TypeName
Concept Adrenal Gland Neoplasms
Concept Bone Neoplasms
Concept Brain Neoplasms
Concept Cerebellar Neoplasms
Concept Colonic Neoplasms
Concept Meningeal Neoplasms
Concept Neoplasms
Concept Neoplasms, Experimental
Concept Skin Neoplasms
Concept Spinal Cord Neoplasms
Concept Infratentorial Neoplasms
Concept Central Nervous System Neoplasms
Academic Article Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer.
Academic Article Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma.
Academic Article Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion.
Academic Article Nestin Mediates Hedgehog Pathway Tumorigenesis.
Academic Article The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.
Academic Article Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.
Academic Article Prediction of central nervous system embryonal tumour outcome based on gene expression.
Academic Article ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease.
Academic Article Mouse embryos cloned from brain tumors.
Academic Article Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma.
Academic Article A molecular fingerprint for medulloblastoma.
Academic Article From bings to biology: taking a different path in cancer research.
Academic Article Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.
Academic Article Gli1 is important for medulloblastoma formation in Ptc1+/- mice.
Academic Article A transcriptome map of cellular transformation by the fos oncogene.
Academic Article Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics.
Academic Article Lost in translation: the future of cancer research?
Academic Article Radial glia cells are candidate stem cells of ependymoma.
Academic Article Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations.
Academic Article Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies.
Academic Article The hedgehog pathway and neurological disorders.
Academic Article Patched2 modulates tumorigenesis in patched1 heterozygous mice.
Academic Article Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor.
Academic Article Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.
Academic Article Cancer: Hedgehog's other great trick.
Academic Article Mouse models and mouse supermodels.
Academic Article The genetic landscape of the childhood cancer medulloblastoma.
Academic Article The Hedgehog's tale: developing strategies for targeting cancer.
Academic Article Q&A: Tom Curran on translational research.
Academic Article Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome.
Academic Article Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study.
Academic Article Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.
Academic Article The Ketogenic Diet Does Not Affect Growth of Hedgehog Pathway Medulloblastoma in Mice.
Academic Article Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53.
Academic Article Whole-exome identifies RXRG and TH germline variants in familial isolated prolactinoma.
Academic Article Inducible proto-oncogenes of the nervous system: their contribution to transcription factors and neuroplasticity.
Academic Article Encounters with Fos and Jun on the road to AP-1.
Academic Article Stimulation and inhibition of growth by EGF in different A431 cell clones is accompanied by the rapid induction of c-fos and c-myc proto-oncogenes.
Academic Article The Fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose.
Academic Article Transient induction of c-fos and c-myc in an immediate consequence of growth factor stimulation.
Academic Article FBR murine osteosarcoma virus. I. Molecular analysis and characterization of a 75,000-Da gag-fos fusion product.
Academic Article Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia.
Academic Article Cell transformation by c-fos requires an extended period of expression and is independent of the cell cycle.
Academic Article Leukotriene Synthesis Is Critical for Medulloblastoma Progression.
Academic Article Origins of Human Cancer: A Comprehensive Review. Cold Spring Harbor Laboratory Press
Academic Article Large-Scale Biomedical Science Exploring Strategies For Future Research Sc. The National Academies Press. Committee on Large-Scale Science and Cancer Research Sharyl J. Nass and Bruce W. Stillman (eds.). The National Academies Press
Academic Article Two Faces of Evil: Cancer and Neurodegeneration, Research Perspectives in Alzheimer's Disease. Foundation IPSEN. Springer
Academic Article In: Encyclopedia of Cancer, 2nd Edition (J. R. Bertino, Ed.)
Award or Honor Receipt Outstanding Achievement in Cancer Research
Award or Honor Receipt President
Academic Article Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality.

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