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One or more keywords matched the following properties of Leeder, J. Steven

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keywords Pediatric Clinical Pharmacology
keywords Pediatric Pharmacogenetics
keywords Pediatric Precision Therapeutics
research overview In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation and Associate Chair-Research, Department of Pediatrics at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. The Pediatric Precision Therapeutics Area of Interest in the Children’s Research Institute complements the Clinical Pharmacology program at Children’s Mercy, the largest in North America. The Precision Therapeutics program extends the Clinical Pharmacology emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the Children’s Research Institute. Dr. Leeder’s research focuses on characterization of the relative contributions of ontogeny, genetic variation and disease to observed variability in drug disposition and response in children. Over the years, these research activities have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids with current funding as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item TypeName
Concept Adult
Concept Ambulatory Care Facilities
Concept Hospitals, Pediatric
Concept Intensive Care Units, Neonatal
Concept Pediatrics
Concept Intensive Care Units, Pediatric
Concept Health Care Costs
Concept Delivery of Health Care, Integrated
Concept Transition Temperature
Concept Young Adult
Concept Pediatric Obesity
Academic Article Pharmacogenetics and pharmacogenomics.
Academic Article The challenges of delivering pharmacogenomics into clinical pediatrics.
Academic Article Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans.
Academic Article Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo.
Academic Article Developmental and pediatric pharmacogenomics.
Academic Article Developmental pharmacology--drug disposition, action, and therapy in infants and children.
Academic Article Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Academic Article Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Academic Article Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Academic Article Variability of CYP3A7 expression in human fetal liver.
Academic Article Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Academic Article CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status.
Academic Article Human anti-cytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions.
Academic Article Application of pharmacogenomic strategies to the study of drug-induced birth defects.
Academic Article The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.
Academic Article Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.
Academic Article Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype.
Academic Article Genetic determinants of variable metabolism have little impact on the clinical use of leading antipsychotics in the CATIE study.
Academic Article Personalized medicine: reality and reality checks.
Academic Article Platform dependence of inference on gene-wise and gene-set involvement in human lung development.
Academic Article Transcriptomic analysis of human lung development.
Academic Article A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma.
Academic Article Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.
Academic Article Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
Academic Article Developmental pharmacogenetics in pediatric rheumatology: utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate.
Academic Article Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation.
Academic Article Conference scene: pediatric pharmacogenomics and personalized medicine.
Academic Article Expression analysis of asthma candidate genes during human and murine lung development.
Academic Article Development of biomarkers to optimize pediatric patient management: what makes children different?
Academic Article Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)
Academic Article Pediatric pharmacogenomics: a systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children.
Academic Article Trends in adverse reactions to trimethoprim-sulfamethoxazole.
Academic Article Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control.
Academic Article High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.
Academic Article Pharmacogenetics in pediatrics. Implications for practice.
Academic Article Epigenetic regulation of ADME-related genes: focus on drug metabolism and transport.
Academic Article Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.
Academic Article CYP2D6 and pharmacogenomics: where does future research need to focus? Part 1: technical aspects.
Academic Article Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.
Academic Article Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population.
Academic Article CYP2D6 and pharmacogenomics: where does future research need to focus? Part 2: clinical aspects.
Academic Article Fetal lung and placental methylation is associated with in utero nicotine exposure.
Academic Article Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics.
Academic Article CYP3A isoforms in Ewing's sarcoma tumours: an immunohistochemical study with clinical correlation.
Academic Article Variability in Expression of CYP3A5 in Human Fetal Liver.
Academic Article Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.
Academic Article Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping.
Academic Article Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study.
Academic Article Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article Design and Testing of an EHR-Integrated, Busulfan Pharmacokinetic Decision Support Tool for the Point-of-Care Clinician.
Academic Article Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.
Academic Article Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.
Academic Article Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.
Academic Article Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping.
Academic Article Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.
Academic Article Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.
Academic Article Investigation of terbinafine as a CYP2D6 inhibitor in vivo.
Academic Article Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children.
Academic Article Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.
Academic Article Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.
Academic Article Dose dependency of dextromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyping.
Academic Article Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
Academic Article Ceftazidime disposition in acute and stable cystic fibrosis.
Academic Article Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing.
Academic Article Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
Academic Article Newborn Sequencing in Genomic Medicine and Public Health.
Academic Article Comparative bioavailability study of three sustained release quinidine formulations.
Academic Article Glucagon therapy for beta-blocker overdose.
Academic Article Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants.
Academic Article Pediatric Pharmacovigilance: Enhancing Adverse Drug Reaction Reporting in a Tertiary Care Children's Hospital.
Academic Article Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Academic Article Pharmacogenomics and implementation of precision therapeutics in the neonatal ICU: a new frontier?
Grant Children's Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology
Academic Article Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults.
Academic Article Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Academic Article Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Academic Article A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents.
Academic Article Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples.
Academic Article Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.
Academic Article Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy
Academic Article In: Problems in Pediatric Drug Therapy, Fourth Edition, Pagliaro LA and Pagliaro AM (Eds)
Academic Article In: Neonatal and Pediatric Pharmacology, Third Edition, Yaffe S and Aranda J, (Eds)
Academic Article In: Nelson Textbook of Pediatrics, 18th Edition, Kliegman, Behrman, Jenson and Stanton, (Eds)
Academic Article In: Neonatal and Pediatric Pharmacology, Fourth Edition, Yaffe S and Aranda J, (Eds
Academic Article In: Nelson Textbook of Pediatrics, 19th Edition, Kliegman RM, Stanton BF, St. Geme III JW, Schor NF, Behrman RE, (Eds)
Academic Article Principles of Drug Administration in Children Receiving Renal Replacement Therapy Second Edition
Academic Article In Biochemical and Molecular Basis of Pediatric Disease, 4th Ed., Wong E, Bennett M, and Dietzen D, eds
Academic Article In: Principles of Pharmacogenetics and Pharmacogenomics, Altman RB, Flockhart D, and Goldstein DB, (Eds),
Academic Article In: Nelson Textbook of Pediatrics, 20th Edition, Kliegman RM, Stanton BF, St. Geme III JW, Schor NF, (Eds)
Academic Article In: Textbook of Pediatric Rheumatology, Seventh Edition, Petty RE, Laxer RM, Lindsley CB, Wedderburn LR, (Eds)
Grant 2019 Drug Metabolism Gordon Research Conference Guiding Drug Development Using Translational ADME Science
Grant PBPK prediction of ontogeny mediated alteration in hepatic drug elimination
Grant Ontogeny and Genetics of NSAID Dose-Exposure Relationship in Preterm Infants
Grant Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
Grant Clinical and Translational Mentored Career Development Award
Grant Frontiers: University of Kansas Clinical and Translational Science Institute
Academic Article Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy.
Academic Article Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Academic Article Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Award or Honor Receipt Sumner J. Yaffe Lifetime Achievement Award in Pediatric Pharmacology and Therapeutics

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