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Leeder, J. Steven

One or more keywords matched the following properties of Leeder, J. Steven

Property	Value
keywords	Pediatric Clinical Pharmacology
keywords	Pediatric Pharmacogenetics
keywords	Pediatric Precision Therapeutics
research overview	In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder is Executive Director (Interim) of the Children’s Mercy Research Institute and leads the Precision Therapeutics Area of Emphasis. The Precision Therapeutics initiative extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Over the years, Dr. Leeder's research interests in pediatric pharmacogenetics and the ontogeny of drug biotransformation pathways during growth and development have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids. Originally funded as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development, "GOLDILOKs" now represents a conceptual approach to better understanding factors contributing to variability in drug disposition and response and using that information to make the use of medications safer and more effective in children of all ages. Dr. Leeder is also co-PI, with Dr. Mario Castro (KUMC), of the Frontiers Clinical and Translational Science Institute at the University of Kansas.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item Type	Name
Concept	Drug Therapy
Concept	Drug Therapy, Combination
Concept	Hospitals, Pediatric
Concept	Pediatrics
Concept	Therapeutic Equivalency
Concept	Intensive Care Units, Pediatric
Concept	Genetic Therapy
Concept	Treatment Outcome
Concept	Precision Medicine
Concept	Opiate Substitution Treatment
Concept	Molecular Targeted Therapy
Concept	Pediatric Obesity
Academic Article	Pharmacogenetics and pharmacogenomics.
Academic Article	The challenges of delivering pharmacogenomics into clinical pediatrics.
Academic Article	Developmental and pediatric pharmacogenomics.
Academic Article	Developmental pharmacology--drug disposition, action, and therapy in infants and children.
Academic Article	Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Academic Article	Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article	Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Academic Article	Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.
Academic Article	The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response.
Academic Article	Developmental pharmacogenetics in pediatric rheumatology: utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate.
Academic Article	Conference scene: pediatric pharmacogenomics and personalized medicine.
Academic Article	Effects of valproic acid on organic acid metabolism in children: a metabolic profiling study.
Academic Article	Development of biomarkers to optimize pediatric patient management: what makes children different?
Academic Article	Safety of lidocaine-prilocaine cream in the treatment of preterm neonates.
Academic Article	Pediatric pharmacogenomics: a systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children.
Academic Article	Trends in adverse reactions to trimethoprim-sulfamethoxazole.
Academic Article	Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control.
Academic Article	Decreased expression of nicotinamide phosphoribosyltransferase in patients with juvenile idiopathic arthritis receiving methotrexate.
Academic Article	Pharmacogenetics in pediatrics. Implications for practice.
Academic Article	Urinary biomarkers of trimethoprim bioactivation in vivo following therapeutic dosing in children.
Academic Article	Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
Academic Article	VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children.
Academic Article	Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.
Academic Article	Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population.
Academic Article	Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response.
Academic Article	Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone.
Academic Article	Acetaminophen overdose with therapeutic intent.
Academic Article	Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research.
Academic Article	Single dose, CYP2D6 genotype-stratified pharmacokinetic study of atomoxetine in children with ADHD.
Academic Article	Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article	Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study.
Academic Article	Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.
Academic Article	Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.
Academic Article	Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children.
Academic Article	Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article	Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.
Academic Article	Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article	Ten Years' Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics.
Academic Article	Acetaminophen intoxication during treatment: what you don't know can hurt you.
Academic Article	Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
Academic Article	Newborn Sequencing in Genomic Medicine and Public Health.
Academic Article	Glucagon therapy for beta-blocker overdose.
Academic Article	Pediatric Pharmacovigilance: Enhancing Adverse Drug Reaction Reporting in a Tertiary Care Children's Hospital.
Academic Article	Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Academic Article	Pharmacogenomics and implementation of precision therapeutics in the neonatal ICU: a new frontier?
Academic Article	Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Academic Article	Considerations for Implementing Precision Therapeutics for Children.
Academic Article	Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Academic Article	Optimization of gentamicin therapy in very low birth weight infants.
Academic Article	Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.
Academic Article	Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy
Academic Article	In: Antimicrobial Therapy in Infants and Children. Koren G, Gold R and Prober C, Ed
Academic Article	In: Problems in Pediatric Drug Therapy, Fourth Edition, Pagliaro LA and Pagliaro AM (Eds)
Academic Article	In: Neonatal and Pediatric Pharmacology, Third Edition, Yaffe S and Aranda J, (Eds)
Academic Article	In: Nelson Textbook of Pediatrics, 18th Edition, Kliegman, Behrman, Jenson and Stanton, (Eds)
Academic Article	In: Neonatal and Pediatric Pharmacology, Fourth Edition, Yaffe S and Aranda J, (Eds
Academic Article	In: Nelson Textbook of Pediatrics, 19th Edition, Kliegman RM, Stanton BF, St. Geme III JW, Schor NF, Behrman RE, (Eds)
Academic Article	Principles of Drug Administration in Children Receiving Renal Replacement Therapy Second Edition
Academic Article	In Biochemical and Molecular Basis of Pediatric Disease, 4th Ed., Wong E, Bennett M, and Dietzen D, eds
Academic Article	In: Principles of Pharmacogenetics and Pharmacogenomics, Altman RB, Flockhart D, and Goldstein DB, (Eds),
Academic Article	In: Nelson Textbook of Pediatrics, 20th Edition, Kliegman RM, Stanton BF, St. Geme III JW, Schor NF, (Eds)
Academic Article	In: Textbook of Pediatric Rheumatology, Seventh Edition, Petty RE, Laxer RM, Lindsley CB, Wedderburn LR, (Eds)
Academic Article	Who Believes They Are "Just Average": Informing the Treatment of Individual Patients Using Population Data.
Grant	Ontogeny and Genetics of NSAID Dose-Exposure Relationship in Preterm Infants
Grant	Trimethoprim: an overlooked contributor of trimethoprim-sulfamethoxazole idiosyncratic adverse drug reactions
Academic Article	Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy.
Award or Honor Receipt	Rawls-Palmer Progress in Medicine Award
Academic Article	A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Academic Article	Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Academic Article	Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Award or Honor Receipt	Sumner J. Yaffe Lifetime Achievement Award in Pediatric Pharmacology and Therapeutics
Academic Article	Ontogeny Related Changes in the Pediatric Liver Metabolome.
Academic Article	Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.
Academic Article	Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
Academic Article	Ontogeny of Pediatric Pharmacogenetics: Celebrating the Past and Vision for the Future.
Academic Article	Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models.
Academic Article	Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes.
Grant	Ontogeny of drug transport
Grant	Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
Grant	Children’s Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology
Grant	Effect of Obesity on Pantoprazole Pharmacokinetics and Pharmacodynamics in Children
Academic Article	Identifying Effective Treatments for Dystonia in Patients With Cerebral Palsy: A Precision Therapeutics Approach.
Academic Article	Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver.
Academic Article	SLCO1B1 Genetic Variation Influence on Atorvastatin Systemic Exposure in Pediatric Hypercholesterolemia.

Search Criteria

Pediatric
Precision
Therapeutics