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One or more keywords matched the following properties of Leeder, J. Steven

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keywords Pediatric Clinical Pharmacology
keywords Pediatric Pharmacogenetics
keywords Pediatric Precision Therapeutics
research overview In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder is Executive Director (Interim) of the Children’s Mercy Research Institute and leads the Precision Therapeutics Area of Emphasis. The Precision Therapeutics initiative extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Over the years, Dr. Leeder's research interests in pediatric pharmacogenetics and the ontogeny of drug biotransformation pathways during growth and development have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids. Originally funded as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development, "GOLDILOKs" now represents a conceptual approach to better understanding factors contributing to variability in drug disposition and response and using that information to make the use of medications safer and more effective in children of all ages. Dr. Leeder is also co-PI, with Dr. Mario Castro (KUMC), of the Frontiers Clinical and Translational Science Institute at the University of Kansas.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item TypeName
Concept Congenital Abnormalities
Concept Abnormalities, Drug-Induced
Concept Apnea
Concept Arthritis, Juvenile
Concept Asthma
Concept Attention Deficit Disorder with Hyperactivity
Concept Blood Pressure
Concept Bone Neoplasms
Concept Breast Feeding
Concept Cerebral Palsy
Concept Common Cold
Concept Cough
Concept Crohn Disease
Concept Cystic Fibrosis
Concept Depressive Disorder, Major
Concept Drug Eruptions
Concept Diabetes Mellitus, Type 2
Concept Diarrhea
Concept Diarrhea, Infantile
Concept Disease Models, Animal
Concept Drug Hypersensitivity
Concept Ductus Arteriosus, Patent
Concept Dystonia
Concept Epilepsy
Concept Epilepsies, Partial
Concept Epilepsy, Tonic-Clonic
Concept Fetal Diseases
Concept Gastroesophageal Reflux
Concept Genetic Markers
Concept Tourette Syndrome
Concept Heart Defects, Congenital
Concept Heart Diseases
Concept Heart Rate
Concept Hemorrhage
Concept Hospitals, Pediatric
Concept Hydrocephalus
Concept Hypercholesterolemia
Concept Hyperlipidemias
Concept Hypersensitivity
Concept Hypersensitivity, Delayed
Concept Hypertension
Concept Iatrogenic Disease
Concept Infant, Low Birth Weight
Concept Infant, Newborn, Diseases
Concept Infant, Premature, Diseases
Concept Kidney Diseases
Concept Lung Diseases
Concept Lymphoma
Concept Meningitis
Concept Metabolism, Inborn Errors
Concept Myocardial Contraction
Concept Opioid-Related Disorders
Concept Nausea
Concept Necrosis
Concept Neonatal Abstinence Syndrome
Concept Neoplasm Metastasis
Concept Neoplasms
Concept Obesity
Concept Obsessive-Compulsive Disorder
Concept Pain
Concept Pediatrics
Concept Postoperative Complications
Concept Prenatal Exposure Delayed Effects
Concept Pseudomonas Infections
Concept Puberty, Precocious
Concept Rhinitis, Allergic, Perennial
Concept Sarcoma, Ewing
Concept Schizophrenia
Concept Stevens-Johnson Syndrome
Concept Thalassemia
Concept Tinea
Concept Tumor Virus Infections
Concept Vomiting
Concept Intensive Care Units, Pediatric
Concept Body Mass Index
Concept Fatal Outcome
Concept Oxidative Stress
Concept Soft Tissue Infections
Concept Maternal Exposure
Concept Gastroschisis
Concept Dystonic Disorders
Concept Hearing Loss
Concept Rare Diseases
Concept Dyslipidemias
Concept Overweight
Concept Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concept Genetic Association Studies
Concept Acute Kidney Injury
Concept Drug Overdose
Concept Pediatric Obesity
Concept Drug-Related Side Effects and Adverse Reactions
Concept Rhinitis, Allergic
Academic Article Pharmacogenetics and pharmacogenomics.
Academic Article The challenges of delivering pharmacogenomics into clinical pediatrics.
Academic Article Developmental and pediatric pharmacogenomics.
Academic Article Developmental pharmacology--drug disposition, action, and therapy in infants and children.
Academic Article Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Academic Article Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article Multiple dose pharmacokinetics of paroxetine in children and adolescents with major depressive disorder or obsessive-compulsive disorder.
Academic Article Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother.
Academic Article Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants.
Academic Article Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine.
Academic Article Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.
Academic Article Effect of counseling on maternal reporting of adverse effects in nursing infants exposed to antibiotics through breast milk.
Academic Article Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.
Academic Article Developmental pharmacogenetics in pediatric rheumatology: utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate.
Academic Article Conference scene: pediatric pharmacogenomics and personalized medicine.
Academic Article Genetic transmission of cytochrome P450 2D6 (CYP2D6) ultrarapid metabolism: implications for breastfeeding women taking codeine.
Academic Article Development of biomarkers to optimize pediatric patient management: what makes children different?
Academic Article Pediatric pharmacogenomics: a systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children.
Academic Article Trends in adverse reactions to trimethoprim-sulfamethoxazole.
Academic Article Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control.
Academic Article Pharmacogenetics in pediatrics. Implications for practice.
Academic Article Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.
Academic Article Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population.
Academic Article Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research.
Academic Article Single dose, CYP2D6 genotype-stratified pharmacokinetic study of atomoxetine in children with ADHD.
Academic Article Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study.
Academic Article Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children.
Academic Article Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
Academic Article Newborn Sequencing in Genomic Medicine and Public Health.
Academic Article Pediatric Pharmacovigilance: Enhancing Adverse Drug Reaction Reporting in a Tertiary Care Children's Hospital.
Academic Article Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Academic Article Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Academic Article Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Academic Article Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.
Academic Article Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy
Academic Article In: Problems in Pediatric Drug Therapy, Fourth Edition, Pagliaro LA and Pagliaro AM (Eds)
Academic Article In: Neonatal and Pediatric Pharmacology, Third Edition, Yaffe S and Aranda J, (Eds)
Academic Article In: Nelson Textbook of Pediatrics, 18th Edition, Kliegman, Behrman, Jenson and Stanton, (Eds)
Academic Article In: Neonatal and Pediatric Pharmacology, Fourth Edition, Yaffe S and Aranda J, (Eds
Academic Article In: Nelson Textbook of Pediatrics, 19th Edition, Kliegman RM, Stanton BF, St. Geme III JW, Schor NF, Behrman RE, (Eds)
Academic Article Principles of Drug Administration in Children Receiving Renal Replacement Therapy Second Edition
Academic Article In Biochemical and Molecular Basis of Pediatric Disease, 4th Ed., Wong E, Bennett M, and Dietzen D, eds
Academic Article In: Principles of Pharmacogenetics and Pharmacogenomics, Altman RB, Flockhart D, and Goldstein DB, (Eds),
Academic Article In: Nelson Textbook of Pediatrics, 20th Edition, Kliegman RM, Stanton BF, St. Geme III JW, Schor NF, (Eds)
Academic Article In: Textbook of Pediatric Rheumatology, Seventh Edition, Petty RE, Laxer RM, Lindsley CB, Wedderburn LR, (Eds)
Academic Article Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy.
Academic Article Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Academic Article Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Award or Honor Receipt Sumner J. Yaffe Lifetime Achievement Award in Pediatric Pharmacology and Therapeutics
Academic Article Ontogeny Related Changes in the Pediatric Liver Metabolome.
Academic Article Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
Academic Article Ontogeny of Pediatric Pharmacogenetics: Celebrating the Past and Vision for the Future.
Academic Article Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models.
Academic Article Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes.
Grant Ontogeny of drug transport
Grant Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
Grant Children’s Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology
Grant Effect of Obesity on Pantoprazole Pharmacokinetics and Pharmacodynamics in Children
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants.
Academic Article Identifying Effective Treatments for Dystonia in Patients With Cerebral Palsy: A Precision Therapeutics Approach.
Academic Article Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver.
Academic Article Population Pharmacokinetic Analysis of Atomoxetine and its Metabolites in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder.
Academic Article SLCO1B1 Genetic Variation Influence on Atorvastatin Systemic Exposure in Pediatric Hypercholesterolemia.

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