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Search Results to J. Steven Leeder

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One or more keywords matched the following properties of Leeder, J. Steven

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keywords Pediatric Clinical Pharmacology
keywords Pediatric Pharmacogenetics
keywords Pediatric Precision Therapeutics
research overview In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation and Associate Chair-Research, Department of Pediatrics at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. The Pediatric Precision Therapeutics Area of Interest in the Children’s Research Institute complements the Clinical Pharmacology program at Children’s Mercy, the largest in North America. The Precision Therapeutics program extends the Clinical Pharmacology emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the Children’s Research Institute. Dr. Leeder’s research focuses on characterization of the relative contributions of ontogeny, genetic variation and disease to observed variability in drug disposition and response in children. Over the years, these research activities have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids with current funding as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item TypeName
Concept Hospitals, Pediatric
Concept Pediatrics
Concept Intensive Care Units, Pediatric
Concept Pediatric Obesity
Academic Article Pharmacogenetics and pharmacogenomics.
Academic Article The challenges of delivering pharmacogenomics into clinical pediatrics.
Academic Article Developmental and pediatric pharmacogenomics.
Academic Article Developmental pharmacology--drug disposition, action, and therapy in infants and children.
Academic Article Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Academic Article Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.
Academic Article Developmental pharmacogenetics in pediatric rheumatology: utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate.
Academic Article Conference scene: pediatric pharmacogenomics and personalized medicine.
Academic Article Development of biomarkers to optimize pediatric patient management: what makes children different?
Academic Article Pediatric pharmacogenomics: a systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children.
Academic Article Trends in adverse reactions to trimethoprim-sulfamethoxazole.
Academic Article Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control.
Academic Article Pharmacogenetics in pediatrics. Implications for practice.
Academic Article Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.
Academic Article Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population.
Academic Article Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study.
Academic Article Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children.
Academic Article Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
Academic Article Newborn Sequencing in Genomic Medicine and Public Health.
Academic Article Pediatric Pharmacovigilance: Enhancing Adverse Drug Reaction Reporting in a Tertiary Care Children's Hospital.
Academic Article Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Grant Children's Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology
Academic Article Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Academic Article Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.
Academic Article Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy
Academic Article In: Problems in Pediatric Drug Therapy, Fourth Edition, Pagliaro LA and Pagliaro AM (Eds)
Academic Article In: Neonatal and Pediatric Pharmacology, Third Edition, Yaffe S and Aranda J, (Eds)
Academic Article In: Nelson Textbook of Pediatrics, 18th Edition, Kliegman, Behrman, Jenson and Stanton, (Eds)
Academic Article In: Neonatal and Pediatric Pharmacology, Fourth Edition, Yaffe S and Aranda J, (Eds
Academic Article In: Nelson Textbook of Pediatrics, 19th Edition, Kliegman RM, Stanton BF, St. Geme III JW, Schor NF, Behrman RE, (Eds)
Academic Article Principles of Drug Administration in Children Receiving Renal Replacement Therapy Second Edition
Academic Article In Biochemical and Molecular Basis of Pediatric Disease, 4th Ed., Wong E, Bennett M, and Dietzen D, eds
Academic Article In: Principles of Pharmacogenetics and Pharmacogenomics, Altman RB, Flockhart D, and Goldstein DB, (Eds),
Academic Article In: Nelson Textbook of Pediatrics, 20th Edition, Kliegman RM, Stanton BF, St. Geme III JW, Schor NF, (Eds)
Academic Article In: Textbook of Pediatric Rheumatology, Seventh Edition, Petty RE, Laxer RM, Lindsley CB, Wedderburn LR, (Eds)
Grant PBPK prediction of ontogeny mediated alteration in hepatic drug elimination
Grant Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
Academic Article Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy.
Academic Article Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Academic Article Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Award or Honor Receipt Sumner J. Yaffe Lifetime Achievement Award in Pediatric Pharmacology and Therapeutics

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