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Search Results to J. Steven Leeder

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research overview In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder leads the Children’s Mercy Research Institute's Precision Therapeutics Area of Emphasis, which extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Over the years, Dr. Leeder's research interests in pediatric pharmacogenetics and the ontogeny of drug biotransformation pathways during growth and development have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids. Originally funded as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development, "GOLDILOKs" now represents a conceptual approach to better understanding factors contributing to variability in drug disposition and response and using that information to make the use of medications safer and more effective in children of all ages.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item TypeName
Concept Child Health Services
Concept Embryonic and Fetal Development
Concept Fetal Diseases
Concept Marketing of Health Services
Concept Maternal Behavior
Concept Maternal-Fetal Exchange
Concept National Health Programs
Concept Public Health
Concept Health Care Costs
Concept Maternal Exposure
Concept Delivery of Health Care, Integrated
Concept Fetal Development
Academic Article The transport of digoxin across the perfused human placental lobule.
Academic Article Developmental and pediatric pharmacogenomics.
Academic Article Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Academic Article Ontogeny of drug metabolizing enzymes in the neonate.
Academic Article Variability of CYP3A7 expression in human fetal liver.
Academic Article Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article Variability of CYP2J2 expression in human fetal tissues.
Academic Article Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects.
Academic Article Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.
Academic Article Effect of counseling on maternal reporting of adverse effects in nursing infants exposed to antibiotics through breast milk.
Academic Article Personalized medicine: reality and reality checks.
Academic Article Transcriptomic analysis of human lung development.
Academic Article Selective Toll--like receptor expression in human fetal lung.
Academic Article Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Academic Article Fetal lung and placental methylation is associated with in utero nicotine exposure.
Academic Article Variability in Expression of CYP3A5 in Human Fetal Liver.
Academic Article Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research.
Academic Article Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.
Academic Article Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.
Academic Article Early pregnancy intrauterine fetal exposure to maternal smoking and impact on fetal telomere length.
Academic Article Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children.
Academic Article Glucuronidation in humans. Pharmacogenetic and developmental aspects.
Academic Article Newborn Sequencing in Genomic Medicine and Public Health.
Academic Article Maternal codeine is not safe for all breast-fed infants
Academic Article Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.
Academic Article In: Maternal-Fetal Toxicology. Koren G, Ed
Academic Article In: Maternal-Fetal Toxicology. A Clinician's Guide, 2nd edition Koren G, Ed
Academic Article The effect of race and supplementation on maternal and umbilical cord plasma folates.
Academic Article A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Grant Frontiers Clinical and Translational Science Institute at the University of Kansas
Grant Children’s Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology

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