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Leeder, J. Steven

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item Type	Name
Concept	Liver
Concept	Microsomes, Liver
Academic Article	Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
Academic Article	Cytochrome P450 pharmacogenetics and anaesthesia.
Academic Article	Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro.
Academic Article	Ontogeny of drug metabolizing enzymes in the neonate.
Academic Article	Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.
Academic Article	Variability of CYP3A7 expression in human fetal liver.
Academic Article	Pathways of carbamazepine bioactivation in vitro: II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene.
Academic Article	CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein?
Academic Article	Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article	Human anti-cytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions.
Academic Article	Biotransformation of fluticasone: in vitro characterization.
Academic Article	Variability of CYP2J2 expression in human fetal tissues.
Academic Article	Expression and inducibility of antigens in severe combined immunodeficient mice recognized by human anti-P450 antibodies.
Academic Article	Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects.
Academic Article	Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
Academic Article	Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
Academic Article	Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation.
Academic Article	Developmental variations in metabolic capacity of flavin-containing mono-oxygenase 3 in childhood.
Academic Article	The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.
Academic Article	Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)
Academic Article	Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Academic Article	Age related changes in fractional elimination pathways for drugs: assessing the impact of variable ontogeny on metabolic drug-drug interactions.
Academic Article	High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.
Academic Article	Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity.
Academic Article	Urinary biomarkers of trimethoprim bioactivation in vivo following therapeutic dosing in children.
Academic Article	Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.
Academic Article	Acetaminophen overdose with therapeutic intent.
Academic Article	Variability in Expression of CYP3A5 in Human Fetal Liver.
Academic Article	In Vitro Hepatic Oxidative Biotransformation of Trimethoprim.
Academic Article	Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article	Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article	Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article	Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.
Academic Article	Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes.
Academic Article	Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.
Academic Article	Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs.
Academic Article	Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase.
Academic Article	Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.
Academic Article	Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.
Academic Article	Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine.
Academic Article	Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article	Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article	Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.
Academic Article	Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice.
Academic Article	Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.
Academic Article	Cellular toxicity of sulfamethoxazole reactive metabolites--II. Inhibition of natural killer activity in human peripheral blood mononuclear cells.
Academic Article	Acetaminophen intoxication during treatment: what you don't know can hurt you.
Academic Article	Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants.
Academic Article	Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Academic Article	Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Academic Article	A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents.
Academic Article	Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples.
Academic Article	In: Handbook of Experimental Pharmacology Volume 121: Drug-Induced Hepatotoxicity. Cameron RG, Feuer G and de la Iglesia F, Eds
Academic Article	In: Drug-Induced Liver Toxicity, 2nd Edition, Kaplowitz N and DeLeve L (Eds.)
Academic Article	In: Drug-Induced Liver Toxicity, 3rd Edition, Kaplowitz N and DeLeve L (Eds.)
Grant	2019 Drug Metabolism Gordon Research Conference Guiding Drug Development Using Translational ADME Science
Academic Article	Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Academic Article	Normalized Testosterone Glucuronide as a Potential Urinary Biomarker for Highly Variable UGT2B17 in Children 7-18 Years.
Academic Article	Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Academic Article	The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites.
Academic Article	Functional Consequences of Pravastatin Isomerization on OATP1B1-Mediated Transport.
Academic Article	Ontogeny Related Changes in the Pediatric Liver Metabolome.
Academic Article	Are body surface area based estimates of liver volume applicable to children with overweight or obesity? An in vivo validation study.
Academic Article	Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
Academic Article	Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans.
Grant	Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
Grant	Effect of Obesity on Pantoprazole Pharmacokinetics and Pharmacodynamics in Children
Academic Article	Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver.
Academic Article	SLCO1B1 Genetic Variation Influence on Atorvastatin Systemic Exposure in Pediatric Hypercholesterolemia.

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