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Leeder, J. Steven

One or more keywords matched the following properties of Leeder, J. Steven

Property	Value
keywords	Developmental Pharmacogenomics
keywords	Pediatric Precision Therapeutics
research overview	In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder is Executive Director (Interim) of the Children’s Mercy Research Institute and leads the Precision Therapeutics Area of Emphasis. The Precision Therapeutics initiative extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Over the years, Dr. Leeder's research interests in pediatric pharmacogenetics and the ontogeny of drug biotransformation pathways during growth and development have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids. Originally funded as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development, "GOLDILOKs" now represents a conceptual approach to better understanding factors contributing to variability in drug disposition and response and using that information to make the use of medications safer and more effective in children of all ages. Dr. Leeder is also co-PI, with Dr. Mario Castro (KUMC), of the Frontiers Clinical and Translational Science Institute at the University of Kansas.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item Type	Name
Concept	Child Development
Concept	Drug Therapy
Concept	Drug Therapy, Combination
Concept	Embryonic and Fetal Development
Concept	Therapeutic Equivalency
Concept	Genetic Therapy
Concept	Program Development
Concept	Treatment Outcome
Concept	Gene Expression Regulation, Developmental
Concept	Adolescent Development
Concept	Fetal Development
Concept	Opiate Substitution Treatment
Concept	Molecular Targeted Therapy
Academic Article	The challenges of delivering pharmacogenomics into clinical pediatrics.
Academic Article	Developmental and pediatric pharmacogenomics.
Academic Article	Developmental pharmacology--drug disposition, action, and therapy in infants and children.
Academic Article	Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Academic Article	Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation.
Academic Article	Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article	Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Academic Article	Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants.
Academic Article	Platform dependence of inference on gene-wise and gene-set involvement in human lung development.
Academic Article	Transcriptomic analysis of human lung development.
Academic Article	Developmental pharmacogenetics: a general paradigm for application to neonatal pharmacology and toxicology.
Academic Article	Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.
Academic Article	Selective Toll--like receptor expression in human fetal lung.
Academic Article	The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response.
Academic Article	Developmental pharmacogenetics in pediatric rheumatology: utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate.
Academic Article	Identifying genomic and developmental causes of adverse drug reactions in children.
Academic Article	Developmental variations in metabolic capacity of flavin-containing mono-oxygenase 3 in childhood.
Academic Article	Effects of valproic acid on organic acid metabolism in children: a metabolic profiling study.
Academic Article	Expression analysis of asthma candidate genes during human and murine lung development.
Academic Article	NTP-CERHR expert panel report on the developmental toxicity of soy infant formula.
Academic Article	The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.
Academic Article	Reversion of the SCID phenotype by human T cell grafts. Development of cross-species immunocompetence.
Academic Article	Development of biomarkers to optimize pediatric patient management: what makes children different?
Academic Article	Interpreting pharmacogenetic data in the developing neonate: the challenge of hitting a moving target.
Academic Article	Safety of lidocaine-prilocaine cream in the treatment of preterm neonates.
Academic Article	Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Academic Article	Decreased expression of nicotinamide phosphoribosyltransferase in patients with juvenile idiopathic arthritis receiving methotrexate.
Academic Article	Pharmacogenetics in pediatrics. Implications for practice.
Academic Article	Vitamin D related genes in lung development and asthma pathogenesis.
Academic Article	Urinary biomarkers of trimethoprim bioactivation in vivo following therapeutic dosing in children.
Academic Article	Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
Academic Article	VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children.
Academic Article	Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response.
Academic Article	Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone.
Academic Article	Acetaminophen overdose with therapeutic intent.
Academic Article	Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research.
Academic Article	Development and Application of a High-Throughput Screening Method to Evaluate Antifungal Activity against Trichophyton tonsurans.
Academic Article	Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.
Academic Article	Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article	Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article	Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article	Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.
Academic Article	Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.
Academic Article	Ten Years' Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics.
Academic Article	Glucuronidation in humans. Pharmacogenetic and developmental aspects.
Academic Article	Acetaminophen intoxication during treatment: what you don't know can hurt you.
Academic Article	Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
Academic Article	Glucagon therapy for beta-blocker overdose.
Academic Article	Pharmacogenomics and implementation of precision therapeutics in the neonatal ICU: a new frontier?
Academic Article	Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Academic Article	Considerations for Implementing Precision Therapeutics for Children.
Academic Article	Optimization of gentamicin therapy in very low birth weight infants.
Academic Article	Developmental aspects of drug metabolism in children
Academic Article	Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.
Academic Article	In: Antimicrobial Therapy in Infants and Children. Koren G, Gold R and Prober C, Ed
Academic Article	In: Problems in Pediatric Drug Therapy, Fourth Edition, Pagliaro LA and Pagliaro AM (Eds)
Academic Article	Principles of Drug Administration in Children Receiving Renal Replacement Therapy Second Edition
Academic Article	In Biochemical and Molecular Basis of Pediatric Disease, 4th Ed., Wong E, Bennett M, and Dietzen D, eds
Academic Article	In: Textbook of Pediatric Rheumatology, Seventh Edition, Petty RE, Laxer RM, Lindsley CB, Wedderburn LR, (Eds)
Academic Article	Who Believes They Are "Just Average": Informing the Treatment of Individual Patients Using Population Data.
Grant	2019 Drug Metabolism Gordon Research Conference Guiding Drug Development Using Translational ADME Science
Grant	Ontogeny and Genetics of NSAID Dose-Exposure Relationship in Preterm Infants
Grant	Clinical and Translational Mentored Career Development Award
Grant	Trimethoprim: an overlooked contributor of trimethoprim-sulfamethoxazole idiosyncratic adverse drug reactions
Award or Honor Receipt	Rawls-Palmer Progress in Medicine Award
Academic Article	Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Award or Honor Receipt	Sumner J. Yaffe Lifetime Achievement Award in Pediatric Pharmacology and Therapeutics
Academic Article	Effect of Intrauterine Smoke Exposure on microRNA-15a Expression in Human Lung Development and Subsequent Asthma Risk.
Academic Article	Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.
Academic Article	Recent advances in the ontogeny of drug disposition.
Academic Article	Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models.
Grant	Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
Grant	Children’s Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology
Grant	Effect of Obesity on Pantoprazole Pharmacokinetics and Pharmacodynamics in Children
Academic Article	Developmental pharmacokinetics of indomethacin in preterm neonates: Severely decreased drug clearance in the first week of life.
Academic Article	Identifying Effective Treatments for Dystonia in Patients With Cerebral Palsy: A Precision Therapeutics Approach.

Search Criteria

Infectious disease
therapeutic
development