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One or more keywords matched the following properties of Leeder, J. Steven

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keywords Developmental Pharmacogenomics
keywords Pediatric Precision Therapeutics
research overview In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder leads the Children’s Mercy Research Institute's Precision Therapeutics Area of Emphasis, which extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Dr. Leeder’s research focuses on characterizing the relative contributions of ontogeny, genetic variation and disease to observed variability in drug disposition and response in children. Over the years, these research activities have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids with current funding as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item TypeName
Concept Child Development
Concept Drug Therapy
Concept Drug Therapy, Combination
Concept Embryonic and Fetal Development
Concept Therapeutic Equivalency
Concept Genetic Therapy
Concept Program Development
Concept Treatment Outcome
Concept Gene Expression Regulation, Developmental
Concept Adolescent Development
Concept Fetal Development
Concept Opiate Substitution Treatment
Concept Molecular Targeted Therapy
Academic Article The challenges of delivering pharmacogenomics into clinical pediatrics.
Academic Article Developmental and pediatric pharmacogenomics.
Academic Article Developmental pharmacology--drug disposition, action, and therapy in infants and children.
Academic Article Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Academic Article Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation.
Academic Article Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Academic Article Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants.
Academic Article Platform dependence of inference on gene-wise and gene-set involvement in human lung development.
Academic Article Transcriptomic analysis of human lung development.
Academic Article Developmental pharmacogenetics: a general paradigm for application to neonatal pharmacology and toxicology.
Academic Article Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.
Academic Article Selective Toll--like receptor expression in human fetal lung.
Academic Article The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response.
Academic Article Developmental pharmacogenetics in pediatric rheumatology: utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate.
Academic Article Identifying genomic and developmental causes of adverse drug reactions in children.
Academic Article Developmental variations in metabolic capacity of flavin-containing mono-oxygenase 3 in childhood.
Academic Article Effects of valproic acid on organic acid metabolism in children: a metabolic profiling study.
Academic Article Expression analysis of asthma candidate genes during human and murine lung development.
Academic Article NTP-CERHR expert panel report on the developmental toxicity of soy infant formula.
Academic Article The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.
Academic Article Reversion of the SCID phenotype by human T cell grafts. Development of cross-species immunocompetence.
Academic Article Development of biomarkers to optimize pediatric patient management: what makes children different?
Academic Article Interpreting pharmacogenetic data in the developing neonate: the challenge of hitting a moving target.
Academic Article Safety of lidocaine-prilocaine cream in the treatment of preterm neonates.
Academic Article Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Academic Article Decreased expression of nicotinamide phosphoribosyltransferase in patients with juvenile idiopathic arthritis receiving methotrexate.
Academic Article Pharmacogenetics in pediatrics. Implications for practice.
Academic Article Vitamin D related genes in lung development and asthma pathogenesis.
Academic Article Urinary biomarkers of trimethoprim bioactivation in vivo following therapeutic dosing in children.
Academic Article Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
Academic Article VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children.
Academic Article Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response.
Academic Article Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone.
Academic Article Acetaminophen overdose with therapeutic intent.
Academic Article Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research.
Academic Article Development and Application of a High-Throughput Screening Method to Evaluate Antifungal Activity against Trichophyton tonsurans.
Academic Article Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.
Academic Article Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.
Academic Article Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.
Academic Article Ten Years' Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics.
Academic Article Glucuronidation in humans. Pharmacogenetic and developmental aspects.
Academic Article Acetaminophen intoxication during treatment: what you don't know can hurt you.
Academic Article Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
Academic Article Glucagon therapy for beta-blocker overdose.
Academic Article Pharmacogenomics and implementation of precision therapeutics in the neonatal ICU: a new frontier?
Academic Article Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Academic Article Considerations for Implementing Precision Therapeutics for Children.
Academic Article Optimization of gentamicin therapy in very low birth weight infants.
Academic Article Developmental aspects of drug metabolism in children
Academic Article Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.
Academic Article In: Antimicrobial Therapy in Infants and Children. Koren G, Gold R and Prober C, Ed
Academic Article In: Problems in Pediatric Drug Therapy, Fourth Edition, Pagliaro LA and Pagliaro AM (Eds)
Academic Article Principles of Drug Administration in Children Receiving Renal Replacement Therapy Second Edition
Academic Article In Biochemical and Molecular Basis of Pediatric Disease, 4th Ed., Wong E, Bennett M, and Dietzen D, eds
Academic Article In: Textbook of Pediatric Rheumatology, Seventh Edition, Petty RE, Laxer RM, Lindsley CB, Wedderburn LR, (Eds)
Academic Article Who Believes They Are "Just Average": Informing the Treatment of Individual Patients Using Population Data.
Grant 2019 Drug Metabolism Gordon Research Conference Guiding Drug Development Using Translational ADME Science
Grant Ontogeny and Genetics of NSAID Dose-Exposure Relationship in Preterm Infants
Grant Clinical and Translational Mentored Career Development Award
Grant Trimethoprim: an overlooked contributor of trimethoprim-sulfamethoxazole idiosyncratic adverse drug reactions
Award or Honor Receipt Rawls-Palmer Progress in Medicine Award
Academic Article Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Award or Honor Receipt Sumner J. Yaffe Lifetime Achievement Award in Pediatric Pharmacology and Therapeutics
Academic Article Effect of Intrauterine Smoke Exposure on microRNA-15a Expression in Human Lung Development and Subsequent Asthma Risk.
Academic Article Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.
Academic Article Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models.
Grant Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
Grant Children’s Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology
Grant Effect of Obesity on Pantoprazole Pharmacokinetics and Pharmacodynamics in Children

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