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research overview In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder leads the Children’s Mercy Research Institute's Precision Therapeutics Area of Emphasis, which extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Dr. Leeder’s research focuses on characterizing the relative contributions of ontogeny, genetic variation and disease to observed variability in drug disposition and response in children. Over the years, these research activities have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids with current funding as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development.

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Concept Age Factors
Concept Herpesvirus 4, Human
Concept Humans
Concept Milk, Human
Concept Risk Factors
Concept Sex Factors
Concept Time Factors
Concept Transcription Factors
Concept Genome, Human
Concept Human Genome Project
Academic Article The transport of digoxin across the perfused human placental lobule.
Academic Article Pharmacogenetics and pharmacogenomics.
Academic Article Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations.
Academic Article Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms.
Academic Article Interactions between N-acetyl-p-benzoquinone imine and fluorescent calcium probes: implications for mechanistic toxicology.
Academic Article Concordance between tramadol and dextromethorphan parent/metabolite ratios: the influence of CYP2D6 and non-CYP2D6 pathways on biotransformation.
Academic Article The challenges of delivering pharmacogenomics into clinical pediatrics.
Academic Article Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans.
Academic Article Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
Academic Article Fluorescence-based viability assay for studies of reactive drug intermediates.
Academic Article Cytochrome P450 pharmacogenetics and anaesthesia.
Academic Article Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo.
Academic Article Developmental and pediatric pharmacogenomics.
Academic Article A high-performance liquid chromatographic method for the measurement of deferoxamine in body fluids.
Academic Article CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism.
Academic Article Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects.
Academic Article Genome-wide prediction, display and refinement of binding sites with information theory-based models.
Academic Article Developmental pharmacology--drug disposition, action, and therapy in infants and children.
Academic Article Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Academic Article Pharmacokinetics of deferoxamine with and without iron load.
Academic Article Comparison of various urine collection intervals for caffeine and dextromethorphan phenotyping in children.
Academic Article Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Academic Article Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation.
Academic Article Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Academic Article A method for meta-analysis of epidemiological studies.
Academic Article Ontogeny of drug metabolizing enzymes in the neonate.
Academic Article Limited association of the 2988g > a single nucleotide polymorphism with CYP2D641 in black subjects.
Academic Article Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.
Academic Article Variability of CYP3A7 expression in human fetal liver.
Academic Article Drug metabolite toxicity assessed in human lymphocytes with a purified, reconstituted cytochrome P-450 system.
Academic Article Pathways of carbamazepine bioactivation in vitro: II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene.
Academic Article CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein?
Academic Article Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Academic Article Multiple dose pharmacokinetics of paroxetine in children and adolescents with major depressive disorder or obsessive-compulsive disorder.
Academic Article CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status.
Academic Article Human anti-cytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions.
Academic Article Bendectin: the wrong way to regulate drug availability.
Academic Article Comments on Hoskins et al. [(2005) drug metab dispos 33:1564-1565].
Academic Article Biotransformation of fluticasone: in vitro characterization.
Academic Article Variability of CYP2J2 expression in human fetal tissues.
Academic Article Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother.
Academic Article Expression and inducibility of antigens in severe combined immunodeficient mice recognized by human anti-P450 antibodies.
Academic Article Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants.
Academic Article Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.
Academic Article Ontogeny of dextromethorphan O- and N-demethylation in the first year of life.
Academic Article Application of pharmacogenomic strategies to the study of drug-induced birth defects.
Academic Article Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype.
Academic Article Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine.
Academic Article The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.
Academic Article A comparative study on computational two-block motif detection: algorithms and applications.
Academic Article CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile.
Academic Article Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects.
Academic Article Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
Academic Article Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.
Academic Article Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype.
Academic Article Genetic determinants of variable metabolism have little impact on the clinical use of leading antipsychotics in the CATIE study.
Academic Article Effect of counseling on maternal reporting of adverse effects in nursing infants exposed to antibiotics through breast milk.
Academic Article Assessment of the impact of renal impairment on systemic exposure of new molecular entities: evaluation of recent new drug applications.
Academic Article Personalized medicine: reality and reality checks.
Academic Article Platform dependence of inference on gene-wise and gene-set involvement in human lung development.
Academic Article Divergence among an international population of Trichophyton tonsurans isolates.
Academic Article Transcriptomic analysis of human lung development.
Academic Article Developmental pharmacogenetics: a general paradigm for application to neonatal pharmacology and toxicology.
Academic Article A novel high-performance liquid chromatography/mass spectrometry method for improved selective and sensitive measurement of methotrexate polyglutamation status in human red blood cells.
Academic Article A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma.
Academic Article CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction.
Academic Article Exogenous but not endogenous EBV induces lymphomas in beige/nude/xid mice carrying human lymphoid xenografts.
Academic Article Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.
Academic Article Analysis of intracellular methotrexate polyglutamates in patients with juvenile idiopathic arthritis: effect of route of administration on variability in intracellular methotrexate polyglutamate concentrations.
Academic Article UGT2B17 and SULT1A1 gene copy number variation (CNV) detection by LabChip microfluidic technology.
Academic Article Impact of the CYP2C19*17 allele on the pharmacokinetics of omeprazole and pantoprazole in children: evidence for a differential effect.
Academic Article Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
Academic Article Selective Toll--like receptor expression in human fetal lung.
Academic Article The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response.
Academic Article Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation.
Academic Article Identifying genomic and developmental causes of adverse drug reactions in children.
Academic Article Conference scene: pediatric pharmacogenomics and personalized medicine.
Academic Article Genetic transmission of cytochrome P450 2D6 (CYP2D6) ultrarapid metabolism: implications for breastfeeding women taking codeine.
Academic Article PharmGKB summary: methotrexate pathway.
Academic Article Developmental variations in metabolic capacity of flavin-containing mono-oxygenase 3 in childhood.
Academic Article Effects of valproic acid on organic acid metabolism in children: a metabolic profiling study.
Academic Article Expression analysis of asthma candidate genes during human and murine lung development.
Academic Article PharmGKB summary: carbamazepine pathway.
Academic Article NTP-CERHR expert panel report on the developmental toxicity of soy infant formula.
Academic Article The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.
Academic Article Reversion of the SCID phenotype by human T cell grafts. Development of cross-species immunocompetence.
Academic Article Development of biomarkers to optimize pediatric patient management: what makes children different?
Academic Article CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR.
Academic Article Measurement of methotrexate polyglutamates in human erythrocytes by ion-pair UPLC-MS/MS.
Academic Article Red blood cell folate concentrations and polyglutamate distribution in juvenile arthritis: predictors of folate variability.
Academic Article Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)
Academic Article PharmGKB summary: phenytoin pathway.
Academic Article Comprehensive quantitative measurement of folate polyglutamates in human erythrocytes by ion pairing ultra-performance liquid chromatography/tandem mass spectrometry.
Academic Article Interpreting pharmacogenetic data in the developing neonate: the challenge of hitting a moving target.
Academic Article Safety of lidocaine-prilocaine cream in the treatment of preterm neonates.
Academic Article Pediatric pharmacogenomics: a systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children.
Academic Article Trends in adverse reactions to trimethoprim-sulfamethoxazole.
Academic Article Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Academic Article Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor.
Academic Article Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control.
Academic Article Valproic acid pathway: pharmacokinetics and pharmacodynamics.
Academic Article Epitope mapping studies with human anti-cytochrome P450 3A antibodies.
Academic Article Decreased expression of nicotinamide phosphoribosyltransferase in patients with juvenile idiopathic arthritis receiving methotrexate.
Academic Article Variability of histamine pharmacodynamic response in children with allergic rhinitis.
Academic Article Age related changes in fractional elimination pathways for drugs: assessing the impact of variable ontogeny on metabolic drug-drug interactions.
Academic Article High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.
Academic Article Pharmacogenetics in pediatrics. Implications for practice.
Academic Article Low-dose methotrexate results in the selective accumulation of aminoimidazole carboxamide ribotide in an erythroblastoid cell line.
Academic Article Epigenetic regulation of ADME-related genes: focus on drug metabolism and transport.
Academic Article Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity.
Academic Article Vitamin D related genes in lung development and asthma pathogenesis.
Academic Article Urinary biomarkers of trimethoprim bioactivation in vivo following therapeutic dosing in children.
Academic Article Drug metabolism for the paediatrician.
Academic Article Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
Academic Article VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children.
Academic Article Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.
Academic Article CYP2D6 and pharmacogenomics: where does future research need to focus? Part 1: technical aspects.
Academic Article Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children.
Academic Article Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.
Academic Article Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population.
Academic Article Individualizing the use of medications in children: making Goldilocks happy.
Academic Article CYP2D6 and pharmacogenomics: where does future research need to focus? Part 2: clinical aspects.
Academic Article Folate depletion and increased glutamation in juvenile idiopathic arthritis patients treated with methotrexate.
Academic Article Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response.
Academic Article Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins.
Academic Article Fetal lung and placental methylation is associated with in utero nicotine exposure.
Academic Article Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics.
Academic Article CYP3A isoforms in Ewing's sarcoma tumours: an immunohistochemical study with clinical correlation.
Academic Article SNP genotyping using TaqMan technology: the CYP2D6*17 assay conundrum.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing.
Academic Article Tissue-specific expression and alternative splicing of human microsomal epoxide hydrolase.
Academic Article Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone.
Academic Article Acetaminophen overdose with therapeutic intent.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
Academic Article Variability in Expression of CYP3A5 in Human Fetal Liver.
Academic Article Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research.
Academic Article Over-the-Counter Medications: Update on Cough and Cold Preparations.
Academic Article In Vitro Hepatic Oxidative Biotransformation of Trimethoprim.
Academic Article CYP2D6 Haplotype Determination Using Long Range Allele-Specific Amplification: Resolution of a Complex Genotype and a Discordant Genotype Involving the CYP2D6*59 Allele.
Academic Article Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.
Academic Article Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article A comparison of the covalent binding of clozapine and olanzapine to human neutrophils in vitro and in vivo.
Academic Article Single dose, CYP2D6 genotype-stratified pharmacokinetic study of atomoxetine in children with ADHD.
Academic Article Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping.
Academic Article Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study.
Academic Article Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease.
Academic Article Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions.
Academic Article Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro.
Academic Article Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.
Academic Article Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.
Academic Article Prediction of CYP2D6 phenotype from genotype across world populations.
Academic Article Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity.
Academic Article Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype.
Academic Article Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.
Academic Article Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes.
Academic Article NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations.
Academic Article Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.
Academic Article Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.
Academic Article Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs.
Academic Article Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.
Academic Article Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping.
Academic Article Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase.
Academic Article Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.
Academic Article Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.
Academic Article Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.
Academic Article Investigation of terbinafine as a CYP2D6 inhibitor in vivo.
Academic Article Early pregnancy intrauterine fetal exposure to maternal smoking and impact on fetal telomere length.
Academic Article Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.
Academic Article Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine.
Academic Article The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database.
Academic Article Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children.
Academic Article Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP.
Academic Article Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.
Academic Article Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article PharmGKB summary: clobazam pathway, pharmacokinetics.
Academic Article Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.
Academic Article Glucuronidation in humans. Pharmacogenetic and developmental aspects.
Academic Article Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.
Academic Article High frequency of CYP2D6 poor and "intermediate" metabolizers in black populations: a review and preliminary data.
Academic Article Cellular toxicity of sulfamethoxazole reactive metabolites--I. Inhibition of intracellular esterase activity prior to cell death.
Academic Article Dose dependency of dextromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyping.
Academic Article Cytochrome P450 3A: ontogeny and drug disposition.
Academic Article Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data.
Academic Article Cellular toxicity of sulfamethoxazole reactive metabolites--II. Inhibition of natural killer activity in human peripheral blood mononuclear cells.
Academic Article Acetaminophen intoxication during treatment: what you don't know can hurt you.
Academic Article Limitations of dextromethorphan N-demethylation as a measure of CYP3A activity.
Academic Article Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
Academic Article Ceftazidime disposition in acute and stable cystic fibrosis.
Academic Article In vitro analysis of metabolic predisposition to drug hypersensitivity reactions.
Academic Article Aprepitant and fosaprepitant drug interactions: a systematic review.
Academic Article Response to 'Aprepitant and fosaprepitant decrease the effectiveness of hormonal contraceptives'.
Academic Article Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing.
Academic Article Evaluation of serum theophylline concentrations following administration of sustained-release beads in applesauce to asthmatic preschool children.
Academic Article Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
Academic Article Newborn Sequencing in Genomic Medicine and Public Health.
Academic Article Comparative bioavailability study of three sustained release quinidine formulations.
Academic Article Cerebrospinal fluid pharmacokinetics of tobramycin, ceftazidime, phenobarbitone and phenytoin in a child.
Academic Article Glucagon therapy for beta-blocker overdose.
Academic Article High-pressure liquid chromatographic analysis of ceftazidime in serum and urine.
Academic Article Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants.
Academic Article Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Academic Article Pharmacogenomics and implementation of precision therapeutics in the neonatal ICU: a new frontier?
Academic Article Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults.
Academic Article Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Academic Article Considerations for Implementing Precision Therapeutics for Children.
Academic Article Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Academic Article Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Academic Article A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents.
Academic Article Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples.
Academic Article Optimization of gentamicin therapy in very low birth weight infants.
Academic Article Pharmacokinetic characteristics of the gonadotropin-releasing hormone analog D-Ser(TBU)-6EA-10luteinizing hormone-releasing hormone (buserelin) after subcutaneous and intranasal administration in children with central precocious puberty.
Academic Article Growth of human lymphoma cells in SCID mice
Academic Article Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.
Academic Article Expedient methodology for total methotrexate polyglutamation pool determination in human erythrocytes
Academic Article Who Believes They Are "Just Average": Informing the Treatment of Individual Patients Using Population Data.
Grant 2019 Drug Metabolism Gordon Research Conference Guiding Drug Development Using Translational ADME Science
Academic Article The effect of race and supplementation on maternal and umbilical cord plasma folates.
Academic Article A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Academic Article Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Academic Article Normalized Testosterone Glucuronide as a Potential Urinary Biomarker for Highly Variable UGT2B17 in Children 7-18 Years.
Academic Article Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Academic Article The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites.
Academic Article Functional Consequences of Pravastatin Isomerization on OATP1B1-Mediated Transport.
Academic Article Effect of Intrauterine Smoke Exposure on microRNA-15a Expression in Human Lung Development and Subsequent Asthma Risk.
Academic Article Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.
Academic Article Analysis Approaches to Identify Pharmacogenetic Associations With Pharmacodynamics.
Academic Article Are body surface area based estimates of liver volume applicable to children with overweight or obesity? An in vivo validation study.
Academic Article Ontogeny of Drug-Metabolizing Enzymes.
Academic Article Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
Academic Article The Impact of Age and Genetics on Naltrexone Biotransformation.
Academic Article The Impact of the CYP2D6 "Enhancer" Single Nucleotide Polymorphism on CYP2D6 Activity.
Academic Article Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans.
Academic Article Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models.
Academic Article Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes.
Grant Ontogeny of drug transport

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