Loading...
Keywords
Last Name
Institution

Connection

Search Results to J. Steven Leeder

This is a "connection" page, showing the details of why an item matched the keywords from your search.

                     
                     

One or more keywords matched the following properties of Leeder, J. Steven

PropertyValue
research overview In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation and Associate Chair-Research, Department of Pediatrics at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. The Pediatric Precision Therapeutics Area of Interest in the Children’s Research Institute complements the Clinical Pharmacology program at Children’s Mercy, the largest in North America. The Precision Therapeutics program extends the Clinical Pharmacology emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the Children’s Research Institute. Dr. Leeder’s research focuses on characterization of the relative contributions of ontogeny, genetic variation and disease to observed variability in drug disposition and response in children. Over the years, these research activities have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids with current funding as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item TypeName
Concept Ambulatory Care Facilities
Concept Chromatography, High Pressure Liquid
Concept Intensive Care Units, Neonatal
Concept Predictive Value of Tests
Concept Reference Values
Concept Intensive Care Units, Pediatric
Concept Health Care Costs
Concept Delivery of Health Care, Integrated
Concept High-Throughput Screening Assays
Concept High-Throughput Nucleotide Sequencing
Academic Article Pharmacogenetics and pharmacogenomics.
Academic Article Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms.
Academic Article Interactions between N-acetyl-p-benzoquinone imine and fluorescent calcium probes: implications for mechanistic toxicology.
Academic Article Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
Academic Article Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo.
Academic Article A high-performance liquid chromatographic method for the measurement of deferoxamine in body fluids.
Academic Article Genome-wide prediction, display and refinement of binding sites with information theory-based models.
Academic Article Variability of CYP3A7 expression in human fetal liver.
Academic Article Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.
Academic Article Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
Academic Article Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype.
Academic Article Personalized medicine: reality and reality checks.
Academic Article Platform dependence of inference on gene-wise and gene-set involvement in human lung development.
Academic Article Transcriptomic analysis of human lung development.
Academic Article A novel high-performance liquid chromatography/mass spectrometry method for improved selective and sensitive measurement of methotrexate polyglutamation status in human red blood cells.
Academic Article A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma.
Academic Article Expression analysis of asthma candidate genes during human and murine lung development.
Academic Article Development of biomarkers to optimize pediatric patient management: what makes children different?
Academic Article Measurement of methotrexate polyglutamates in human erythrocytes by ion-pair UPLC-MS/MS.
Academic Article Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes.
Academic Article Comprehensive quantitative measurement of folate polyglutamates in human erythrocytes by ion pairing ultra-performance liquid chromatography/tandem mass spectrometry.
Academic Article Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Academic Article High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.
Academic Article Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children.
Academic Article Fetal lung and placental methylation is associated with in utero nicotine exposure.
Academic Article Development and Application of a High-Throughput Screening Method to Evaluate Antifungal Activity against Trichophyton tonsurans.
Academic Article Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.
Academic Article Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping.
Academic Article Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study.
Academic Article Design and Testing of an EHR-Integrated, Busulfan Pharmacokinetic Decision Support Tool for the Point-of-Care Clinician.
Academic Article Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype.
Academic Article Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.
Academic Article Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.
Academic Article Investigation of terbinafine as a CYP2D6 inhibitor in vivo.
Academic Article Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.
Academic Article Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children.
Academic Article Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences.
Academic Article Erratum: Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences.
Academic Article Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article High frequency of CYP2D6 poor and "intermediate" metabolizers in black populations: a review and preliminary data.
Academic Article Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing.
Academic Article Newborn Sequencing in Genomic Medicine and Public Health.
Academic Article High-pressure liquid chromatographic analysis of ceftazidime in serum and urine.
Academic Article Pediatric Pharmacovigilance: Enhancing Adverse Drug Reaction Reporting in a Tertiary Care Children's Hospital.
Academic Article Pharmacogenomics and implementation of precision therapeutics in the neonatal ICU: a new frontier?
Academic Article Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Grant 2019 Drug Metabolism Gordon Research Conference Guiding Drug Development Using Translational ADME Science
Grant PBPK prediction of ontogeny mediated alteration in hepatic drug elimination
Grant Ontogeny and Genetics of NSAID Dose-Exposure Relationship in Preterm Infants
Grant Clinical and Translational Mentored Career Development Award
Grant Frontiers: University of Kansas Clinical and Translational Science Institute
Grant Trimethoprim: an overlooked contributor of trimethoprim-sulfamethoxazole idiosyncratic adverse drug reactions
Academic Article Normalized Testosterone Glucuronide as a Potential Urinary Biomarker for Highly Variable UGT2B17 in Children 7-18 Years.

Search Criteria
  • High
  • Value
  • Care