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research overview In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder is Executive Director (Interim) of the Children’s Mercy Research Institute and leads the Precision Therapeutics Area of Emphasis. The Precision Therapeutics initiative extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Over the years, Dr. Leeder's research interests in pediatric pharmacogenetics and the ontogeny of drug biotransformation pathways during growth and development have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids. Originally funded as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development, "GOLDILOKs" now represents a conceptual approach to better understanding factors contributing to variability in drug disposition and response and using that information to make the use of medications safer and more effective in children of all ages. Dr. Leeder is also co-PI, with Dr. Mario Castro (KUMC), of the Frontiers Clinical and Translational Science Institute at the University of Kansas.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item TypeName
Concept Genomics
Concept Genomic Structural Variation
Concept Precision Medicine
Academic Article Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Academic Article Personalized medicine: reality and reality checks.
Academic Article Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
Academic Article Developmental pharmacogenetics in pediatric rheumatology: utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate.
Academic Article Identifying genomic and developmental causes of adverse drug reactions in children.
Academic Article Conference scene: pediatric pharmacogenomics and personalized medicine.
Academic Article PharmGKB summary: methotrexate pathway.
Academic Article PharmGKB summary: carbamazepine pathway.
Academic Article Red blood cell folate concentrations and polyglutamate distribution in juvenile arthritis: predictors of folate variability.
Academic Article PharmGKB summary: phenytoin pathway.
Academic Article Valproic acid pathway: pharmacokinetics and pharmacodynamics.
Academic Article Vitamin D related genes in lung development and asthma pathogenesis.
Academic Article VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children.
Academic Article Single dose, CYP2D6 genotype-stratified pharmacokinetic study of atomoxetine in children with ADHD.
Academic Article Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.
Academic Article Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.
Academic Article PharmGKB summary: clobazam pathway, pharmacokinetics.
Academic Article Newborn Sequencing in Genomic Medicine and Public Health.
Academic Article Pharmacogenomics and implementation of precision therapeutics in the neonatal ICU: a new frontier?
Academic Article Considerations for Implementing Precision Therapeutics for Children.
Academic Article A systematic approach to implementing monogenic genomic medicine: Genotype-driven diagnosis of genetic diseases
Academic Article Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy
Academic Article Who Believes They Are "Just Average": Informing the Treatment of Individual Patients Using Population Data.
Academic Article Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy.
Award or Honor Receipt Rawls-Palmer Progress in Medicine Award
Academic Article A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Academic Article Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes.
Grant Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
Grant Children’s Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology

Search Criteria
  • Genomic
  • medicine