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Leeder, J. Steven

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item Type	Name
Concept	Disease Models, Animal
Concept	Mixed Function Oxygenases
Concept	Models, Biological
Concept	Models, Genetic
Concept	Models, Molecular
Concept	Models, Theoretical
Concept	Models, Statistical
Concept	Linear Models
Concept	Models, Immunological
Concept	Models, Animal
Academic Article	Pharmacogenetics and pharmacogenomics.
Academic Article	Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo.
Academic Article	Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutations.
Academic Article	Genome-wide prediction, display and refinement of binding sites with information theory-based models.
Academic Article	Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Academic Article	Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation.
Academic Article	Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.
Academic Article	The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.
Academic Article	CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile.
Academic Article	Exogenous but not endogenous EBV induces lymphomas in beige/nude/xid mice carrying human lymphoid xenografts.
Academic Article	Expression analysis of asthma candidate genes during human and murine lung development.
Academic Article	Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)
Academic Article	Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes.
Academic Article	Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Academic Article	Epitope mapping studies with human anti-cytochrome P450 3A antibodies.
Academic Article	Age related changes in fractional elimination pathways for drugs: assessing the impact of variable ontogeny on metabolic drug-drug interactions.
Academic Article	A modified generalized Fisher method for combining probabilities from dependent tests.
Academic Article	Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.
Academic Article	Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study.
Academic Article	Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article	Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.
Academic Article	Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.
Academic Article	Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs.
Academic Article	Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.
Academic Article	Early pregnancy intrauterine fetal exposure to maternal smoking and impact on fetal telomere length.
Academic Article	Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine.
Academic Article	Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
Academic Article	Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Academic Article	A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents.
Grant	2019 Drug Metabolism Gordon Research Conference Guiding Drug Development Using Translational ADME Science
Academic Article	Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
Academic Article	Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models.
Academic Article	Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective.
Grant	Ontogeny of drug transport
Grant	Effect of Obesity on Pantoprazole Pharmacokinetics and Pharmacodynamics in Children
Academic Article	Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver.

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