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Leeder, J. Steven

One or more keywords matched the following properties of Leeder, J. Steven

Property	Value
keywords	Adverse Drug Reactions
keywords	Developmental Pharmacogenomics
research overview	In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder is Executive Director (Interim) of the Children’s Mercy Research Institute and leads the Precision Therapeutics Area of Emphasis. The Precision Therapeutics initiative extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Over the years, Dr. Leeder's research interests in pediatric pharmacogenetics and the ontogeny of drug biotransformation pathways during growth and development have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids. Originally funded as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development, "GOLDILOKs" now represents a conceptual approach to better understanding factors contributing to variability in drug disposition and response and using that information to make the use of medications safer and more effective in children of all ages. Dr. Leeder is also co-PI, with Dr. Mario Castro (KUMC), of the Frontiers Clinical and Translational Science Institute at the University of Kansas.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item Type	Name
Concept	Abnormalities, Drug-Induced
Concept	Acetaminophen
Concept	Acetylcysteine
Concept	Acetyltransferases
Concept	Acute-Phase Proteins
Concept	Adenosine Triphosphate
Concept	Adrenal Cortex Hormones
Concept	Adrenergic beta-Antagonists
Concept	Alcohol Dehydrogenase
Concept	Ethanol
Concept	Aldehyde Dehydrogenase
Concept	Aminoimidazole Carboxamide
Concept	Central Nervous System Stimulants
Concept	Analgesics
Concept	Analgesics, Opioid
Concept	Androgens
Concept	Androstadienes
Concept	Aniline Compounds
Concept	Antibodies, Anti-Idiotypic
Concept	Anti-Infective Agents
Concept	Anti-Infective Agents, Local
Concept	Anti-Infective Agents, Urinary
Concept	Anti-Inflammatory Agents
Concept	Anti-Ulcer Agents
Concept	Anti-Bacterial Agents
Concept	Antibiotics, Antineoplastic
Concept	Antibodies
Concept	Antibodies, Monoclonal
Concept	Anticoagulants
Concept	Anticonvulsants
Concept	Antidepressive Agents
Concept	Antiemetics
Concept	Antifungal Agents
Concept	Epitopes
Concept	Antigens
Concept	Antimetabolites
Concept	Antimetabolites, Antineoplastic
Concept	Antineoplastic Agents
Concept	Antioxidants
Concept	Antitussive Agents
Concept	Aryl Hydrocarbon Hydroxylases
Concept	Arylamine N-Acetyltransferase
Concept	Autoantibodies
Concept	Autoantigens
Concept	Baclofen
Concept	Base Sequence
Concept	Beclomethasone
Concept	Benzhydryl Compounds
Concept	Benzodiazepines
Concept	Binding Sites
Concept	Binding Sites, Antibody
Concept	Bronchodilator Agents
Concept	Buserelin
Concept	Caffeine
Concept	Calcium
Concept	Carbamazepine
Concept	Carbon Dioxide
Concept	Carbon Isotopes
Concept	Carboxylic Acids
Concept	Carboxylic Ester Hydrolases
Concept	Carrier Proteins
Concept	Catechol O-Methyltransferase
Concept	Ceftazidime
Concept	Cephalosporins
Concept	Child Development
Concept	Ciprofloxacin
Concept	Cisplatin
Concept	Clotrimazole
Concept	Clozapine
Concept	Codeine
Concept	Contraceptive Agents
Concept	Contraceptives, Oral
Concept	Cotinine
Concept	Cytochrome P-450 Enzyme System
Concept	Cytosine
Concept	Debrisoquin
Concept	Deferoxamine
Concept	Dehydroepiandrosterone
Concept	Delayed-Action Preparations
Concept	Drug Eruptions
Concept	Deuterium
Concept	Dexamethasone
Concept	Dextromethorphan
Concept	Dextrorphan
Concept	Dibenzazepines
Concept	Dicyclomine
Concept	Digoxin
Concept	Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
Concept	Disulfides
Concept	Dithionitrobenzoic Acid
Concept	DNA
Concept	DNA, Fungal
Concept	DNA, Viral
Concept	Dosage Forms
Concept	Dose-Response Relationship, Drug
Concept	Doxylamine
Concept	Drug Administration Routes
Concept	Drug Administration Schedule
Concept	Drug Combinations
Concept	Drug Evaluation
Concept	Drug Hypersensitivity
Concept	Drug Industry
Concept	Drug Interactions
Concept	Drug Labeling
Concept	Drug Evaluation, Preclinical
Concept	Drug Therapy
Concept	Drug Therapy, Combination
Concept	Pharmaceutical Preparations
Concept	Nonprescription Drugs
Concept	Environmental Pollutants
Concept	Enzyme Inhibitors
Concept	Enzymes
Concept	Epoxide Hydrolases
Concept	Erythromycin
Concept	Esterases
Concept	Ethanolamines
Concept	Ethinyl Estradiol
Concept	Exons
Concept	Expectorants
Concept	Factor V
Concept	Fatty Acids, Unsaturated
Concept	Ferredoxin-NADP Reductase
Concept	Embryonic and Fetal Development
Concept	Fluoresceins
Concept	Fluorescent Dyes
Concept	Fluoxetine
Concept	Folic Acid
Concept	Folic Acid Antagonists
Concept	Gentamicins
Concept	Glucagon
Concept	Glucose
Concept	Glucuronates
Concept	Glutathione
Concept	Glutathione Reductase
Concept	Glutathione Transferase
Concept	Haptens
Concept	Heat-Shock Proteins
Concept	Histamine
Concept	Histamine Antagonists
Concept	HLA Antigens
Concept	Mixed Function Oxygenases
Concept	Hypnotics and Sedatives
Concept	Hypochlorous Acid
Concept	Immunoglobulin G
Concept	Imines
Concept	Immune Sera
Concept	Immunosuppressive Agents
Concept	Indoles
Concept	Indomethacin
Concept	Introns
Concept	Ionophores
Concept	Ions
Concept	Iron
Concept	Isoenzymes
Concept	Isoflavones
Concept	Isomerases
Concept	Ketoconazole
Concept	Peptidyl-Dipeptidase A
Concept	Lactones
Concept	Legislation, Drug
Concept	Lidocaine
Concept	Cholesterol, LDL
Concept	Luciferases
Concept	Membrane Glycoproteins
Concept	Methionine Sulfoximine
Concept	Methotrexate
Concept	Methylamines
Concept	Methyltransferases
Concept	Metoprolol
Concept	Metronidazole
Concept	Microfilament Proteins
Concept	Midazolam
Concept	Mitogens
Concept	Morphine
Concept	Morpholines
Concept	Muscle Relaxants, Central
Concept	Peroxidase
Concept	NAD
Concept	NADP
Concept	NADPH-Ferrihemoprotein Reductase
Concept	Naltrexone
Concept	Naphthalenes
Concept	Narcotic Antagonists
Concept	Neoplasm Proteins
Concept	Nicotine
Concept	Nitriles
Concept	Nitrobenzoates
Concept	Norgestrel
Concept	Omeprazole
Concept	Oxidoreductases
Concept	Oxidoreductases, N-Demethylating
Concept	Oximes
Concept	Oxycodone
Concept	Oxygenases
Concept	Peptide Fragments
Concept	Phenethylamines
Concept	Phenobarbital
Concept	Phenols
Concept	Phenytoin
Concept	Phosphodiesterase Inhibitors
Concept	Pimozide
Concept	Pirenzepine
Concept	Plasmids
Concept	Polyglutamic Acid
Concept	Prilocaine
Concept	Promoter Regions, Genetic
Concept	Propylamines
Concept	Protein-Tyrosine Kinases
Concept	Proteins
Concept	Proto-Oncogene Proteins
Concept	Pteroylpolyglutamic Acids
Concept	Pulmonary Surfactants
Concept	Pyridines
Concept	Pyridoxine
Concept	Quinidine
Concept	Receptors, Steroid
Concept	Receptors, Virus
Concept	Recombinant Proteins
Concept	Ribonucleotides
Concept	RNA
Concept	RNA, Messenger
Concept	Serotonin
Concept	Stereoisomerism
Concept	Steroid Hydroxylases
Concept	Sulfamethoxazole
Concept	Sulfates
Concept	Sulfonamides
Concept	Teratogens
Concept	Testosterone
Concept	Tetrahydrofolates
Concept	Tetrazolium Salts
Concept	Theophylline
Concept	Thiazoles
Concept	Thromboxane-A Synthase
Concept	Tobramycin
Concept	Tramadol
Concept	Antipsychotic Agents
Concept	Anti-Anxiety Agents
Concept	Transcription Factors
Concept	Transferases
Concept	Triglycerides
Concept	Trimethoprim
Concept	Biomarkers, Tumor
Concept	Glucuronosyltransferase
Concept	United States Food and Drug Administration
Concept	Valproic Acid
Concept	Nasal Decongestants
Concept	Vitamin D
Concept	Vitamin K
Concept	Vitamins
Concept	Warfarin
Concept	Xanthenes
Concept	Xanthine Oxidase
Concept	Drug Design
Concept	Zidovudine
Concept	Sulfotransferases
Concept	Arylsulfotransferase
Concept	Xenobiotics
Concept	Citalopram
Concept	Drugs, Investigational
Concept	Trimethoprim, Sulfamethoxazole Drug Combination
Concept	Gene Library
Concept	Mifepristone
Concept	Minor Histocompatibility Antigens
Concept	Free Radical Scavengers
Concept	Cytokines
Concept	Benzoquinones
Concept	Drug Delivery Systems
Concept	Drug Costs
Concept	Tacrolimus
Concept	Bupropion
Concept	NAD(P)H Dehydrogenase (Quinone)
Concept	Fluvoxamine
Concept	Program Development
Concept	Adverse Drug Reaction Reporting Systems
Concept	Pravastatin
Concept	Paroxetine
Concept	Investigational New Drug Application
Concept	Alternative Splicing
Concept	Receptors, Opioid, mu
Concept	DNA Primers
Concept	DNA, Complementary
Concept	Receptors, Cytoplasmic and Nuclear
Concept	Antirheumatic Agents
Concept	Gene Expression Regulation, Developmental
Concept	Antidepressive Agents, Second-Generation
Concept	Excitatory Amino Acid Antagonists
Concept	Antimanic Agents
Concept	Analgesics, Non-Narcotic
Concept	Adrenergic Uptake Inhibitors
Concept	Molecular Chaperones
Concept	CpG Islands
Concept	Anti-Allergic Agents
Concept	Anti-Asthmatic Agents
Concept	Anthracyclines
Concept	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Concept	Buthionine Sulfoximine
Concept	Lactic Acid
Concept	Cytochrome P-450 CYP1A1
Concept	Cytochrome P-450 CYP1A2
Concept	Cytochrome P-450 CYP2D6
Concept	Cytochrome P-450 CYP2E1
Concept	Protein Disulfide-Isomerases
Concept	Intramolecular Oxidoreductases
Concept	Simvastatin
Concept	Protective Agents
Concept	Tyrphostins
Concept	Protein Isoforms
Concept	Tandem Repeat Sequences
Concept	Cisapride
Concept	Response Elements
Concept	Sertraline
Concept	Glucuronides
Concept	DNA, Ribosomal Spacer
Concept	Tacrolimus Binding Proteins
Concept	RNA Splice Sites
Concept	Mitochondrial Proteins
Concept	E-Box Elements
Concept	Membrane Transport Proteins
Concept	Organic Anion Transporters
Concept	Multidrug Resistance-Associated Proteins
Concept	Organic Cation Transporter 1
Concept	Organic Anion Transporters, Sodium-Independent
Concept	Soybean Proteins
Concept	Steroid 16-alpha-Hydroxylase
Concept	Adolescent Development
Concept	Methylenetetrahydrofolate Reductase (NADPH2)
Concept	Carboxylesterase
Concept	Fetal Development
Concept	Retinoid X Receptors
Concept	Phytoestrogens
Concept	Serotonin Plasma Membrane Transport Proteins
Concept	Betaine-Homocysteine S-Methyltransferase
Concept	Wnt Proteins
Concept	Toll-Like Receptors
Concept	Toll-Like Receptor 2
Concept	Toll-Like Receptor 4
Concept	Aquaporin 1
Concept	Aquaporin 2
Concept	Cytochrome P-450 CYP3A
Concept	Hepatocyte Nuclear Factor 4
Concept	CCAAT-Enhancer-Binding Protein-delta
Concept	Oseltamivir
Concept	Janus Kinase 2
Concept	2-Pyridinylmethylsulfinylbenzimidazoles
Concept	Proton Pump Inhibitors
Concept	Nicotinamide Phosphoribosyltransferase
Concept	Drug Dosage Calculations
Concept	Lipocalins
Concept	Prescription Drugs
Concept	Antipyretics
Concept	Drug Overdose
Concept	Sulfonylurea Receptors
Concept	Vitamin K Epoxide Reductases
Concept	Drug-Related Side Effects and Adverse Reactions
Concept	Cytochrome P-450 Enzyme Inhibitors
Concept	Cytochrome P-450 CYP1A2 Inhibitors
Concept	Cytochrome P-450 CYP1B1
Concept	Cytochrome P-450 CYP2A6
Concept	Cytochrome P-450 CYP2D6 Inhibitors
Concept	Cytochrome P-450 CYP3A Inhibitors
Concept	Cytochrome P-450 CYP2C9 Inducers
Concept	Cytochrome P-450 CYP2B6
Concept	Cytochrome P-450 CYP2C9
Concept	Cytochrome P-450 CYP2C19
Academic Article	Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms.
Academic Article	Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine.
Academic Article	Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
Academic Article	Fluorescence-based viability assay for studies of reactive drug intermediates.
Academic Article	Developmental and pediatric pharmacogenomics.
Academic Article	A high-performance liquid chromatographic method for the measurement of deferoxamine in body fluids.
Academic Article	Developmental pharmacology--drug disposition, action, and therapy in infants and children.
Academic Article	Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro.
Academic Article	Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Academic Article	Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Academic Article	Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation.
Academic Article	Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Academic Article	A method for meta-analysis of epidemiological studies.
Academic Article	Ontogeny of drug metabolizing enzymes in the neonate.
Academic Article	Drug metabolite toxicity assessed in human lymphocytes with a purified, reconstituted cytochrome P-450 system.
Academic Article	Pathways of carbamazepine bioactivation in vitro: II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene.
Academic Article	Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article	Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Academic Article	Multiple dose pharmacokinetics of paroxetine in children and adolescents with major depressive disorder or obsessive-compulsive disorder.
Academic Article	CYP2D636 gene arrangements within the cyp2d6 locus: association of CYP2D636 with poor metabolizer status.
Academic Article	Human anti-cytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions.
Academic Article	Bendectin: the wrong way to regulate drug availability.
Academic Article	Comments on Hoskins et al. [(2005) drug metab dispos 33:1564-1565].
Academic Article	Biotransformation of fluticasone: in vitro characterization.
Academic Article	Expression and inducibility of antigens in severe combined immunodeficient mice recognized by human anti-P450 antibodies.
Academic Article	Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants.
Academic Article	Application of pharmacogenomic strategies to the study of drug-induced birth defects.
Academic Article	CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile.
Academic Article	Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects.
Academic Article	Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
Academic Article	Effect of counseling on maternal reporting of adverse effects in nursing infants exposed to antibiotics through breast milk.
Academic Article	Assessment of the impact of renal impairment on systemic exposure of new molecular entities: evaluation of recent new drug applications.
Academic Article	Personalized medicine: reality and reality checks.
Academic Article	Platform dependence of inference on gene-wise and gene-set involvement in human lung development.
Academic Article	Transcriptomic analysis of human lung development.
Academic Article	Developmental pharmacogenetics: a general paradigm for application to neonatal pharmacology and toxicology.
Academic Article	Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.
Academic Article	Analysis of intracellular methotrexate polyglutamates in patients with juvenile idiopathic arthritis: effect of route of administration on variability in intracellular methotrexate polyglutamate concentrations.
Academic Article	Impact of the CYP2C19*17 allele on the pharmacokinetics of omeprazole and pantoprazole in children: evidence for a differential effect.
Academic Article	Selective Toll--like receptor expression in human fetal lung.
Academic Article	The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response.
Academic Article	Developmental pharmacogenetics in pediatric rheumatology: utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate.
Academic Article	Identifying genomic and developmental causes of adverse drug reactions in children.
Academic Article	Conference scene: pediatric pharmacogenomics and personalized medicine.
Academic Article	Genetic transmission of cytochrome P450 2D6 (CYP2D6) ultrarapid metabolism: implications for breastfeeding women taking codeine.
Academic Article	Developmental variations in metabolic capacity of flavin-containing mono-oxygenase 3 in childhood.
Academic Article	Expression analysis of asthma candidate genes during human and murine lung development.
Academic Article	NTP-CERHR expert panel report on the developmental toxicity of soy infant formula.
Academic Article	The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.
Academic Article	Reversion of the SCID phenotype by human T cell grafts. Development of cross-species immunocompetence.
Academic Article	Development of biomarkers to optimize pediatric patient management: what makes children different?
Academic Article	Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)
Academic Article	Interpreting pharmacogenetic data in the developing neonate: the challenge of hitting a moving target.
Academic Article	Pediatric pharmacogenomics: a systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children.
Academic Article	Trends in adverse reactions to trimethoprim-sulfamethoxazole.
Academic Article	Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Academic Article	Epitope mapping studies with human anti-cytochrome P450 3A antibodies.
Academic Article	Decreased expression of nicotinamide phosphoribosyltransferase in patients with juvenile idiopathic arthritis receiving methotrexate.
Academic Article	Age related changes in fractional elimination pathways for drugs: assessing the impact of variable ontogeny on metabolic drug-drug interactions.
Academic Article	Pharmacogenetics in pediatrics. Implications for practice.
Academic Article	Low-dose methotrexate results in the selective accumulation of aminoimidazole carboxamide ribotide in an erythroblastoid cell line.
Academic Article	Epigenetic regulation of ADME-related genes: focus on drug metabolism and transport.
Academic Article	Vitamin D related genes in lung development and asthma pathogenesis.
Academic Article	Urinary biomarkers of trimethoprim bioactivation in vivo following therapeutic dosing in children.
Academic Article	Drug metabolism for the paediatrician.
Academic Article	VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children.
Academic Article	Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.
Academic Article	Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.
Academic Article	Individualizing the use of medications in children: making Goldilocks happy.
Academic Article	Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response.
Academic Article	Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins.
Academic Article	Acetaminophen overdose with therapeutic intent.
Academic Article	Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
Academic Article	Variability in Expression of CYP3A5 in Human Fetal Liver.
Academic Article	Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research.
Academic Article	Over-the-Counter Medications: Update on Cough and Cold Preparations.
Academic Article	In Vitro Hepatic Oxidative Biotransformation of Trimethoprim.
Academic Article	Development and Application of a High-Throughput Screening Method to Evaluate Antifungal Activity against Trichophyton tonsurans.
Academic Article	Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.
Academic Article	Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article	Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article	Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease.
Academic Article	Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article	Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.
Academic Article	Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.
Academic Article	Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity.
Academic Article	Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes.
Academic Article	Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.
Academic Article	Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs.
Academic Article	Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.
Academic Article	Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.
Academic Article	Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine.
Academic Article	Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children.
Academic Article	Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article	Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.
Academic Article	Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice.
Academic Article	Glucuronidation in humans. Pharmacogenetic and developmental aspects.
Academic Article	Cellular toxicity of sulfamethoxazole reactive metabolites--I. Inhibition of intracellular esterase activity prior to cell death.
Academic Article	Dose dependency of dextromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyping.
Academic Article	Cytochrome P450 3A: ontogeny and drug disposition.
Academic Article	Acetaminophen intoxication during treatment: what you don't know can hurt you.
Academic Article	Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
Academic Article	In vitro analysis of metabolic predisposition to drug hypersensitivity reactions.
Academic Article	Aprepitant and fosaprepitant drug interactions: a systematic review.
Academic Article	Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing.
Academic Article	Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
Academic Article	Glucagon therapy for beta-blocker overdose.
Academic Article	Pediatric Pharmacovigilance: Enhancing Adverse Drug Reaction Reporting in a Tertiary Care Children's Hospital.
Academic Article	Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Academic Article	Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Academic Article	Considerations for Implementing Precision Therapeutics for Children.
Academic Article	Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Academic Article	Optimization of gentamicin therapy in very low birth weight infants.
Academic Article	Developmental aspects of drug metabolism in children
Academic Article	Ontogeny of drug-metabolizing enzymes and its influence on the pathogenesis of adverse drug reactions in children
Academic Article	Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.
Academic Article	In: Handbook of Experimental Pharmacology Volume 121: Drug-Induced Hepatotoxicity. Cameron RG, Feuer G and de la Iglesia F, Eds
Academic Article	In: Metabolic Drug Interactions, Levy RH, Thummel KE, Trager WF, Hansten PD and Eichelbaum M, eds
Academic Article	In: Antiepileptic Drugs, 5th Edition, Levy RH et al, (Eds.)
Academic Article	In: Problems in Pediatric Drug Therapy, Fourth Edition, Pagliaro LA and Pagliaro AM (Eds)
Academic Article	In: Drug-Induced Liver Toxicity, 2nd Edition, Kaplowitz N and DeLeve L (Eds.)
Academic Article	Principles of Drug Administration in Children Receiving Renal Replacement Therapy Second Edition
Academic Article	In Biochemical and Molecular Basis of Pediatric Disease, 4th Ed., Wong E, Bennett M, and Dietzen D, eds
Academic Article	In: Drug-Induced Liver Toxicity, 3rd Edition, Kaplowitz N and DeLeve L (Eds.)
Academic Article	In: Textbook of Pediatric Rheumatology, Seventh Edition, Petty RE, Laxer RM, Lindsley CB, Wedderburn LR, (Eds)
Academic Article	Who Believes They Are "Just Average": Informing the Treatment of Individual Patients Using Population Data.
Grant	2019 Drug Metabolism Gordon Research Conference Guiding Drug Development Using Translational ADME Science
Grant	Ontogeny and Genetics of NSAID Dose-Exposure Relationship in Preterm Infants
Grant	Clinical and Translational Mentored Career Development Award
Grant	Trimethoprim: an overlooked contributor of trimethoprim-sulfamethoxazole idiosyncratic adverse drug reactions
Academic Article	A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Academic Article	Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Academic Article	The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites.
Academic Article	Functional Consequences of Pravastatin Isomerization on OATP1B1-Mediated Transport.
Academic Article	Effect of Intrauterine Smoke Exposure on microRNA-15a Expression in Human Lung Development and Subsequent Asthma Risk.
Academic Article	Recent advances in the ontogeny of drug disposition.
Academic Article	Ontogeny of Drug-Metabolizing Enzymes.
Academic Article	Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
Academic Article	The Impact of Age and Genetics on Naltrexone Biotransformation.
Academic Article	Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans.
Academic Article	Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models.
Academic Article	Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective.
Grant	Ontogeny of drug transport
Grant	Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
Grant	Children’s Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology
Grant	Effect of Obesity on Pantoprazole Pharmacokinetics and Pharmacodynamics in Children
Academic Article	Isolation and Identification of 3,4-Seco-Solanidine-3,4-dioic acid (SSDA) as a Urinary Biomarker of Cytochrome P450 2D6 (CYP2D6) Activity.
Academic Article	Developmental pharmacokinetics of indomethacin in preterm neonates: Severely decreased drug clearance in the first week of life.
Academic Article	Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver.

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