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Search Results to J. Steven Leeder

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One or more keywords matched the following properties of Leeder, J. Steven

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keywords Developmental Pharmacogenomics
research overview In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder is Executive Director (Interim) of the Children’s Mercy Research Institute and leads the Precision Therapeutics Area of Emphasis. The Precision Therapeutics initiative extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Over the years, Dr. Leeder's research interests in pediatric pharmacogenetics and the ontogeny of drug biotransformation pathways during growth and development have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids. Originally funded as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development, "GOLDILOKs" now represents a conceptual approach to better understanding factors contributing to variability in drug disposition and response and using that information to make the use of medications safer and more effective in children of all ages. Dr. Leeder is also co-PI, with Dr. Mario Castro (KUMC), of the Frontiers Clinical and Translational Science Institute at the University of Kansas.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item TypeName
Concept Child Health Services
Concept Crohn Disease
Concept Disease Models, Animal
Concept Fetal Diseases
Concept Heart Diseases
Concept Iatrogenic Disease
Concept Infant, Newborn, Diseases
Concept Infant, Premature, Diseases
Concept Kidney Diseases
Concept Lung Diseases
Concept Marketing of Health Services
Concept National Health Programs
Concept Public Health
Concept Health Care Costs
Concept Disease Progression
Concept Gene Expression Regulation, Developmental
Concept Delivery of Health Care, Integrated
Concept Disease Management
Concept Genetic Predisposition to Disease
Concept Rare Diseases
Academic Article Developmental and pediatric pharmacogenomics.
Academic Article Developmental pharmacology--drug disposition, action, and therapy in infants and children.
Academic Article Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Academic Article Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine.
Academic Article Assessment of the impact of renal impairment on systemic exposure of new molecular entities: evaluation of recent new drug applications.
Academic Article Personalized medicine: reality and reality checks.
Academic Article Developmental pharmacogenetics: a general paradigm for application to neonatal pharmacology and toxicology.
Academic Article Exogenous but not endogenous EBV induces lymphomas in beige/nude/xid mice carrying human lymphoid xenografts.
Academic Article Selective Toll--like receptor expression in human fetal lung.
Academic Article Developmental pharmacogenetics in pediatric rheumatology: utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate.
Academic Article Identifying genomic and developmental causes of adverse drug reactions in children.
Academic Article Developmental variations in metabolic capacity of flavin-containing mono-oxygenase 3 in childhood.
Academic Article Expression analysis of asthma candidate genes during human and murine lung development.
Academic Article NTP-CERHR expert panel report on the developmental toxicity of soy infant formula.
Academic Article Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Academic Article Vitamin D related genes in lung development and asthma pathogenesis.
Academic Article Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response.
Academic Article CYP3A isoforms in Ewing's sarcoma tumours: an immunohistochemical study with clinical correlation.
Academic Article Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone.
Academic Article Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research.
Academic Article Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.
Academic Article Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease.
Academic Article Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.
Academic Article Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.
Academic Article Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.
Academic Article Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children.
Academic Article Glucuronidation in humans. Pharmacogenetic and developmental aspects.
Academic Article Acetaminophen intoxication during treatment: what you don't know can hurt you.
Academic Article Ceftazidime disposition in acute and stable cystic fibrosis.
Academic Article Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing.
Academic Article Newborn Sequencing in Genomic Medicine and Public Health.
Academic Article Developmental aspects of drug metabolism in children
Academic Article Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.
Academic Article A systematic approach to implementing monogenic genomic medicine: Genotype-driven diagnosis of genetic diseases
Academic Article In Biochemical and Molecular Basis of Pediatric Disease, 4th Ed., Wong E, Bennett M, and Dietzen D, eds
Grant Ontogeny and Genetics of NSAID Dose-Exposure Relationship in Preterm Infants
Academic Article A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Academic Article Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Academic Article Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes.
Grant Frontiers Clinical and Translational Science Institute at the University of Kansas
Grant Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
Grant Children’s Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology
Grant Effect of Obesity on Pantoprazole Pharmacokinetics and Pharmacodynamics in Children
Academic Article Developmental pharmacokinetics of indomethacin in preterm neonates: Severely decreased drug clearance in the first week of life.

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