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keywords Pediatric Clinical Pharmacology
research overview Dr. Gaedigk's research interests focus on genes involved in drug metabolism, transport and response and how genetic variation can explain the wide ranges of variability that are observed for protein function among individuals. Since many drugs are metabolized by Cytochrome P450 enzymes, much of her work has revolved around CYP enzymes, in particular CYP2D6. During her career, she has characterized the CYP2D6 gene locus in many ethnically different populations, discovered numerous allelic variants and developed methods that reliably identify variant alleles. Dr Gaedigk is the PI of the federally funded Pharmacogene Variation Consortium (PharmVar), which provides PGx gene nomenclature by serving as a centralized “next Generation’ pharmacogene data repository. In this capacity, she is also closely working with the Pharmacogenomic Knowledgebase (PharmGKB), a globally renown pharmacogenetics resource. Furthermore, her pharmacogenomic expertise is also recognized by her leadership role on several Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. Lastly, Dr. Gaedigk is also part of the GOLDILOKs initiative (Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids) that seeks to better understand atomoxetine treatment for ADHD and develop clinical decision tools to optimize PGx-guided drug therapy.

One or more keywords matched the following items that are connected to Gaedigk, Andrea

Item TypeName
Concept Adult
Concept Child Day Care Centers
Concept Transition Temperature
Concept Young Adult
Concept Pediatric Obesity
Academic Article Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe.
Academic Article Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans.
Academic Article Effect of sex and menstrual cycle phase on cytochrome P450 2C19 activity with omeprazole used as a biomarker.
Academic Article Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Academic Article Limited sampling strategy of S-warfarin concentrations, but not warfarin S/R ratios, accurately predicts S-warfarin AUC during baseline and inhibition in CYP2C9 extensive metabolizers.
Academic Article Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction.
Academic Article Lack of weight-based dose dependency and intraindividual variability of omeprazole for CYP2C19 phenotyping.
Academic Article Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Academic Article Variability of CYP3A7 expression in human fetal liver.
Academic Article Identification of CYP2D6 impaired functional alleles in Mexican Americans.
Academic Article Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Academic Article CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status.
Academic Article Maribavir pharmacokinetics and the effects of multiple-dose maribavir on cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2, and xanthine oxidase activities in healthy adults.
Academic Article Effects of fluvastatin and cigarette smoking on CYP2C9 activity measured using the probe S-warfarin.
Academic Article Tracking Trichophyton tonsurans through a large urban child care center: defining infection prevalence and transmission patterns by molecular strain typing.
Academic Article Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity.
Academic Article The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.
Academic Article Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.
Academic Article Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype.
Academic Article Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual.
Academic Article Genetic determinants of variable metabolism have little impact on the clinical use of leading antipsychotics in the CATIE study.
Academic Article Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions.
Academic Article Variability in drug metabolizing enzyme activity in HIV-infected patients.
Academic Article Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations.
Academic Article Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
Academic Article Genetic variants of the drug-metabolizing enzyme CYP2D6 in Puerto Rican psychiatry patients: a preliminary report and potential implications for breast cancer patients.
Academic Article Assessment of activity levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 genes by population pharmacokinetics of dextromethorphan.
Academic Article The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients.
Academic Article Defining risk factors for red man syndrome in children and adults.
Academic Article Characterization of the CYP2D6 gene locus and metabolic activity in Indo- and Afro-Trinidadians: discovery of novel allelic variants.
Academic Article High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.
Academic Article Pharmacogenetics in American Indian populations: analysis of CYP2D6, CYP3A4, CYP3A5, and CYP2C9 in the Confederated Salish and Kootenai Tribes.
Academic Article Polymorphisms in CYP2D6 may predict methamphetamine related heart failure.
Academic Article Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.
Academic Article CYP2D6 and pharmacogenomics: where does future research need to focus? Part 1: technical aspects.
Academic Article Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population.
Academic Article CYP2D6 and pharmacogenomics: where does future research need to focus? Part 2: clinical aspects.
Academic Article Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics.
Academic Article Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver.
Academic Article Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population.
Academic Article Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort.
Academic Article Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article Role of Pharmacogenetics in Improving the Safety of Psychiatric Care by Predicting the Potential Risks of Mania in CYP2D6 Poor Metabolizers Diagnosed With Bipolar Disorder.
Academic Article Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article Prediction of Warfarin Dose in Pediatric Patients: An Evaluation of the Predictive Performance of Several Models.
Academic Article Comparison of three CYP2D6 probe substrates and genotype in Ghanaians, Chinese and Caucasians.
Academic Article Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.
Academic Article Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping.
Academic Article Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.
Academic Article Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.
Academic Article Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs.
Academic Article Impact of CYP2D6 on venlafaxine metabolism in Trinidadian patients with major depressive disorder.
Academic Article Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.
Academic Article Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.
Academic Article Dose dependency of dextromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyping.
Academic Article Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
Academic Article Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Academic Article Integrated CYP2D6 interrogation for multiethnic copy number and tandem allele detection.
Academic Article Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Academic Article Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Grant Pharmacogenetics of Warfarin in Pediatrics Patients
Grant Precision Medicine in Pediatric Rehabilitation - Variability in Oral Baclofen Exposure and Response
Grant Pediatric Off-Patient Study (PODS) Center for lorazepam sedation
Grant Research Fellowship Program in Pediatric Clinical/Developmental Pharmacology
Grant Research Fellowship Program in Pediatric Clinical/Developmental Pharmacology
Grant Exogenous and endogenous biomarkers of CYP2D6 variability in pediatrics
Grant Children’s Center for Clinical Pharmacology Studies (Pediatric Pharmacology Research Unit)
Academic Article Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia.

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