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Search Results to Andrea Gaedigk

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One or more keywords matched the following properties of Gaedigk, Andrea

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keywords Pediatric Clinical Pharmacology
keywords Pharmacogenetics and Genomics
preferred title Director, Pharmacogenetics Core Laboratory
research overview Dr. Gaedigk's research interests focus on genes involved in drug metabolism, transport and response and how genetic variation can explain the wide ranges of variability that are observed for protein function among individuals. Since many drugs are metabolized by Cytochrome P450 enzymes, much of her work has revolved around CYP enzymes, in particular CYP2D6. During her career, she has characterized the CYP2D6 gene locus in many ethnically different populations, discovered numerous allelic variants and developed methods that reliably identify variant alleles. Dr Gaedigk is the Director of the Pharmacogene Variation Consortium (PharmVar), which provides PGx gene nomenclature by serving as a centralized “next Generation’ pharmacogene data repository. In this capacity, she is also closely working with the Pharmacogenomic Knowledgebase (PharmGKB), a globally renown pharmacogenetics resource. Furthermore, her pharmacogenomic expertise is also recognized by her leadership role on several Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. Lastly, Dr. Gaedigk is also part of the GOLDILOKs initiative (Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids) that seeks to better understand atomoxetine treatment for ADHD and develop clinical decision tools to optimize PGx-guided drug therapy.

One or more keywords matched the following items that are connected to Gaedigk, Andrea

Item TypeName
Concept Hospitals, Pediatric
Concept Pharmacogenetics
Concept Pediatric Obesity
Academic Article Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction.
Academic Article Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.
Academic Article Effects of fluvastatin and cigarette smoking on CYP2C9 activity measured using the probe S-warfarin.
Academic Article Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother.
Academic Article Tracking Trichophyton tonsurans through a large urban child care center: defining infection prevalence and transmission patterns by molecular strain typing.
Academic Article The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.
Academic Article Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects.
Academic Article Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.
Academic Article CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction.
Academic Article Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions.
Academic Article Elucidation of CYP2D6 genetic diversity in a unique African population: implications for the future application of pharmacogenetics in the Xhosa population.
Academic Article Detection and characterization of the CYP2D6*9x2 gene duplication in two Spanish populations: resolution of AmpliChip CYP450 test no-calls.
Academic Article CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype.
Academic Article Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants.
Academic Article Characterization of the CYP2D6 gene locus and metabolic activity in Indo- and Afro-Trinidadians: discovery of novel allelic variants.
Academic Article High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.
Academic Article Pharmacogenetics in American Indian populations: analysis of CYP2D6, CYP3A4, CYP3A5, and CYP2C9 in the Confederated Salish and Kootenai Tribes.
Academic Article Complexities of CYP2D6 gene analysis and interpretation.
Academic Article Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
Academic Article Challenges in CYP2D6 phenotype assignment from genotype data: a critical assessment and call for standardization.
Academic Article Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.
Academic Article CYP2D6 and pharmacogenomics: where does future research need to focus? Part 1: technical aspects.
Academic Article Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population.
Academic Article CYP2D6 and pharmacogenomics: where does future research need to focus? Part 2: clinical aspects.
Academic Article Resolution of a clinical AmpliChip CYP450 Test™ no call: discovery and characterization of novel CYP2D6*1 haplotypes.
Academic Article Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics.
Academic Article Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
Academic Article Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population.
Academic Article In vivo characterization of CYP2D6*12, *29 and *84 using dextromethorphan as a probe drug: a case report.
Academic Article Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting.
Academic Article Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort.
Academic Article Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article CYP450 genotype and pharmacogenetic association studies: a critical appraisal.
Academic Article Role of Pharmacogenetics in Improving the Safety of Psychiatric Care by Predicting the Potential Risks of Mania in CYP2D6 Poor Metabolizers Diagnosed With Bipolar Disorder.
Academic Article Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions.
Academic Article Prediction of CYP2D6 phenotype from genotype across world populations.
Academic Article Prediction of Warfarin Dose in Pediatric Patients: An Evaluation of the Predictive Performance of Several Models.
Academic Article Pharmacogenetics to prevent maniac affective switching with treatment for bipolar disorder: CYP2D6.
Academic Article NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations.
Academic Article Comparison of three CYP2D6 probe substrates and genotype in Ghanaians, Chinese and Caucasians.
Academic Article Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and use of ondansetron and tropisetron.
Academic Article Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping.
Academic Article Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: a pilot study.
Academic Article Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort.
Academic Article Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.
Academic Article The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database.
Academic Article Impact of CYP2D6 on venlafaxine metabolism in Trinidadian patients with major depressive disorder.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy.
Academic Article Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data.
Academic Article Limitations of dextromethorphan N-demethylation as a measure of CYP3A activity.
Academic Article CYP2D6 genotype analysis of a Thai population: platform comparison.
Academic Article Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Academic Article Integrated CYP2D6 interrogation for multiethnic copy number and tandem allele detection.
Academic Article Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Academic Article The Case for Pharmacogenetics-Guided Prescribing of Codeine in Children.
Academic Article Pharmacogene Variation Consortium Gene Introduction: NUDT15.
Academic Article CYP2C9*61, a rare missense variant identified in a Puerto Rican patient with low warfarin dose requirements.
Academic Article Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy.
Academic Article Pharmacogenetics: Chasing Perfection.
Academic Article PharmVar GeneFocus: CYP2D6.
Grant Pharmacogenetics of Warfarin in Pediatrics Patients
Grant Precision Medicine in Pediatric Rehabilitation - Variability in Oral Baclofen Exposure and Response
Grant Pediatric Off-Patient Study (PODS) Center for lorazepam sedation
Grant Research Fellowship Program in Pediatric Clinical/Developmental Pharmacology
Grant Research Fellowship Program in Pediatric Clinical/Developmental Pharmacology
Grant Exogenous and endogenous biomarkers of CYP2D6 variability in pediatrics
Grant Children’s Center for Clinical Pharmacology Studies (Pediatric Pharmacology Research Unit)
Academic Article Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group.
Academic Article The McGraw-Hill Companies, New York, Bertino, J.S. Jr., Kashuba, A.D.M., Ma, J.D., Fuhr, U. and DeVane, C.L. (eds.)
Academic Article Textbook of Pharmacogenomics: an Introduction and Clinical Perspective. The McGraw-Hill Companies, New York, Bertino, J.S. Jr., Kashuba, A.D.M., Ma, J.D., Fuhr, U. and DeVane, C.L. (eds.)
Academic Article CRC Press/Taylor & Francis Group, Ye, S.Q. (ed.)
Academic Article A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Academic Article PharmVar and the Landscape of Pharmacogenetic Resources.
Academic Article Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Academic Article Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2C9 and Nonsteroidal Anti-Inflammatory Drugs.
Academic Article PharmVar GeneFocus: CYP2C19.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing.
Academic Article Retrospective Review of Pharmacogenetic Testing at an Academic Children's Hospital.
Academic Article Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.
Academic Article PharmVar GeneFocus: CYP2B6.
Academic Article Relationship between CYP2D6 genotype, activity score and phenotype in a pediatric Thai population treated with risperidone.
Academic Article CYP2D6 genotype and reduced codeine analgesic effect in real-world clinical practice.
Academic Article Genetic variability of CYP2D6, CYP3A4 and CYP3A5 among the Egyptian population.
Academic Article Resolving discordant CYP2D6 genotyping results in Thai subjects: platform limitations and novel haplotypes.
Academic Article Characterization of Reference Materials with an Association for Molecular Pathology Pharmacogenetics Working Group Tier 2 Status: CYP2C9, CYP2C19, VKORC1, CYP2C Cluster Variant, and GGCX: A GeT-RM Collaborative Project.
Academic Article Pharmacogene Variation Consortium: A Global Resource and Repository for Pharmacogene Variation.
Academic Article PharmVar GeneFocus: CYP2C9.
Academic Article Recommendations for Clinical CYP2D6 Genotyping Allele Selection: A Joint Consensus Recommendation of the Association for Molecular Pathology, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, and the European Society for Pharmacogenomics and Personalized Therapy.
Academic Article Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
Academic Article Pharmacogenomics Factors Influencing the Effect of Risperidone on Prolactin Levels in Thai Pediatric Patients With Autism Spectrum Disorder.
Academic Article Editorial: NSAIDs Pharmacogenomics.
Academic Article Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update.
Academic Article The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms.
Academic Article Clinical pharmacogenomic testing and reporting: A technical standard of the American College of Medical Genetics and Genomics (ACMG).
Academic Article CYP2D6 gene resequencing in the Malagasy, a population at the crossroads between Asia and Africa: a pilot study.
Academic Article Case Report: Pharmacogenetics Applied to Precision Psychiatry Could Explain the Outcome of a Patient With a New CYP2D6 Genotype.
Academic Article Influence of CYP2D6 genetic variation on adverse events with propafenone in the pediatric and young adult population.
Academic Article TPMT and NUDT15 Genotyping Recommendations: A Joint Consensus Recommendation of the Association for Molecular Pathology, Clinical Pharmacogenetics Implementation Consortium, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy, and Pharmacogenomics Knowledgebase.

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  • Pediatric
  • Pharmacogenetics