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Gaedigk, Andrea

One or more keywords matched the following properties of Gaedigk, Andrea

Property	Value
keywords	Precision Medicine
keywords	Pharmacogenetics and Genomics
research overview	Dr. Gaedigk's research interests focus on genes involved in drug metabolism, transport and response and how genetic variation can explain the wide ranges of variability that are observed for protein function among individuals. Since many drugs are metabolized by Cytochrome P450 enzymes, much of her work has revolved around CYP enzymes, in particular CYP2D6. During her career, she has characterized the CYP2D6 gene locus in many ethnically different populations, discovered numerous allelic variants and developed methods that reliably identify variant alleles. Dr Gaedigk is the Director of the Pharmacogene Variation Consortium (PharmVar), which provides PGx gene nomenclature by serving as a centralized “next Generation’ pharmacogene data repository. In this capacity, she is also closely working with the Pharmacogenomic Knowledgebase (PharmGKB), a globally renown pharmacogenetics resource. Furthermore, her pharmacogenomic expertise is also recognized by her leadership role on several Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. Lastly, Dr. Gaedigk is also part of the GOLDILOKs initiative (Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids) that seeks to better understand atomoxetine treatment for ADHD and develop clinical decision tools to optimize PGx-guided drug therapy.

One or more keywords matched the following items that are connected to Gaedigk, Andrea

Item Type	Name
Concept	Genomics
Academic Article	Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
Academic Article	CYP2D6 update: revised nomenclature for CYP2D7/2D6 hybrid genes.
Academic Article	Pharmacogenetics in American Indian populations: analysis of CYP2D6, CYP3A4, CYP3A5, and CYP2C9 in the Confederated Salish and Kootenai Tribes.
Academic Article	Cloning, structural organization, and chromosomal mapping of the human phenol sulfotransferase STP2 gene.
Academic Article	Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting.
Academic Article	Single dose, CYP2D6 genotype-stratified pharmacokinetic study of atomoxetine in children with ADHD.
Academic Article	Role of Pharmacogenetics in Improving the Safety of Psychiatric Care by Predicting the Potential Risks of Mania in CYP2D6 Poor Metabolizers Diagnosed With Bipolar Disorder.
Academic Article	Precision medicine: does ethnicity information complement genotype-based prescribing decisions?
Academic Article	Pharmacogenetics: Chasing Perfection.
Grant	Precision Medicine in Pediatric Rehabilitation - Variability in Oral Baclofen Exposure and Response
Grant	GOLDILOKs: Genomic- and Ontogeny-Linked Dose Individualization and CLinical Optimization for Kids
Academic Article	A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Academic Article	Recommendations for Clinical CYP2D6 Genotyping Allele Selection: A Joint Consensus Recommendation of the Association for Molecular Pathology, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, and the European Society for Pharmacogenomics and Personalized Therapy.
Academic Article	Clinical pharmacogenomic testing and reporting: A technical standard of the American College of Medical Genetics and Genomics (ACMG).

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Genomic
medicine