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Gaedigk, Andrea

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research overview

Dr. Gaedigk's research interests focus on genes involved in drug metabolism, transport and response and how genetic variation can explain the wide ranges of variability that are observed for protein function among individuals. Since many drugs are metabolized by Cytochrome P450 enzymes, much of her work has revolved around CYP enzymes, in particular CYP2D6. During her career, she has characterized the CYP2D6 gene locus in many ethnically different populations, discovered numerous allelic variants and developed methods that reliably identify variant alleles. Dr Gaedigk is the Director of the Pharmacogene Variation Consortium (PharmVar), which provides PGx gene nomenclature by serving as a centralized “next Generation’ pharmacogene data repository. In this capacity, she is also closely working with the Pharmacogenomic Knowledgebase (PharmGKB), a globally renown pharmacogenetics resource. Furthermore, her pharmacogenomic expertise is also recognized by her leadership role on several Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. Lastly, Dr. Gaedigk is also part of the GOLDILOKs initiative (Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids) that seeks to better understand atomoxetine treatment for ADHD and develop clinical decision tools to optimize PGx-guided drug therapy.

One or more keywords matched the following items that are connected to Gaedigk, Andrea

Item Type	Name
Concept	Abnormalities, Drug-Induced
Concept	Acetaminophen
Concept	Acetyltransferases
Concept	Adrenal Cortex Hormones
Concept	Adrenergic beta-Antagonists
Concept	Alcohol Dehydrogenase
Concept	Aldehyde Dehydrogenase
Concept	Alkynes
Concept	Amines
Concept	Aminobiphenyl Compounds
Concept	Amitriptyline
Concept	Central Nervous System Stimulants
Concept	Analgesics, Opioid
Concept	Androgens
Concept	Anti-Arrhythmia Agents
Concept	Anti-Infective Agents, Local
Concept	Anti-Inflammatory Agents, Non-Steroidal
Concept	Anti-Ulcer Agents
Concept	Antibodies
Concept	Anticoagulants
Concept	Anticonvulsants
Concept	Antidepressive Agents
Concept	Antidepressive Agents, Tricyclic
Concept	Antiemetics
Concept	Antifibrinolytic Agents
Concept	Epitopes
Concept	Antimalarials
Concept	Antimetabolites
Concept	Antimetabolites, Antineoplastic
Concept	Antitussive Agents
Concept	Antiviral Agents
Concept	Aryl Hydrocarbon Hydroxylases
Concept	Arylamine N-Acetyltransferase
Concept	Autoantigens
Concept	Baclofen
Concept	Base Sequence
Concept	Benzimidazoles
Concept	Binding Sites
Concept	Binding Sites, Antibody
Concept	Caffeine
Concept	Carbamazepine
Concept	Carbon Dioxide
Concept	Carbon Isotopes
Concept	Carboxy-Lyases
Concept	Carboxylic Ester Hydrolases
Concept	Carcinogens
Concept	Carrier Proteins
Concept	Catechol O-Methyltransferase
Concept	Catecholamines
Concept	Chloroquine
Concept	Clotrimazole
Concept	Codeine
Concept	Contraceptives, Oral
Concept	Crystallization
Concept	Cyclopropanes
Concept	Cytochrome P-450 Enzyme System
Concept	Debrisoquin
Concept	Dehydroepiandrosterone
Concept	Dextromethorphan
Concept	Dextrorphan
Concept	Disulfides
Concept	DNA
Concept	DNA, Fungal
Concept	DNA, Ribosomal
Concept	Dopamine
Concept	Dose-Response Relationship, Drug
Concept	Drug Administration Schedule
Concept	Drug Combinations
Concept	Drug Hypersensitivity
Concept	Drug Interactions
Concept	Drug Labeling
Concept	Drug Resistance
Concept	Pharmaceutical Preparations
Concept	Enzyme Inhibitors
Concept	Epoxide Hydrolases
Concept	Ethanolamines
Concept	Ethinyl Estradiol
Concept	Exons
Concept	Fatty Acids, Monounsaturated
Concept	Fluorenes
Concept	Fluoxetine
Concept	Fungal Proteins
Concept	Haptens
Concept	Heterocyclic Compounds
Concept	Amine Oxidase (Copper-Containing)
Concept	Histamine
Concept	HLA Antigens
Concept	Mixed Function Oxygenases
Concept	Hypnotics and Sedatives
Concept	Immunosuppressive Agents
Concept	Indoles
Concept	Indomethacin
Concept	Insulin-Like Growth Factor I
Concept	Introns
Concept	Isoenzymes
Concept	Luciferases
Concept	Membrane Proteins
Concept	Methamphetamine
Concept	Methyltransferases
Concept	Metoprolol
Concept	Midazolam
Concept	Morphine
Concept	Muscle Relaxants, Central
Concept	NADPH-Ferrihemoprotein Reductase
Concept	Neoplasm Proteins
Concept	Nitrophenols
Concept	Norgestrel
Concept	Nuclear Proteins
Concept	Omeprazole
Concept	Oxidoreductases, N-Demethylating
Concept	Oxygenases
Concept	Aminosalicylic Acid
Concept	Peptide Fragments
Concept	Phenylethyl Alcohol
Concept	Phenols
Concept	Phenytoin
Concept	Phosphoadenosine Phosphosulfate
Concept	Phosphodiesterase Inhibitors
Concept	Pimozide
Concept	Plasmids
Concept	Platelet Aggregation Inhibitors
Concept	Drug Prescriptions
Concept	Primaquine
Concept	Prodrugs
Concept	Promoter Regions, Genetic
Concept	Propafenone
Concept	Propylamines
Concept	Proteins
Concept	Pyrimidinones
Concept	Pyrophosphatases
Concept	Recombinant Fusion Proteins
Concept	Recombinant Proteins
Concept	Reference Standards
Concept	Ribonucleosides
Concept	Rifampin
Concept	RNA
Concept	RNA, Fungal
Concept	RNA, Messenger
Concept	RNA, Ribosomal
Concept	Serotonin
Concept	Growth Hormone
Concept	Sparteine
Concept	Stereoisomerism
Concept	Steroid Hydroxylases
Concept	Sulfamethazine
Concept	Sulfates
Concept	Tamoxifen
Concept	Testosterone
Concept	Thromboxane-A Synthase
Concept	Ticlopidine
Concept	Tramadol
Concept	Antipsychotic Agents
Concept	Anti-Anxiety Agents
Concept	Tumor Necrosis Factor-alpha
Concept	Glucuronosyltransferase
Concept	Vancomycin
Concept	Vitamin K
Concept	Vitamins
Concept	Warfarin
Concept	Xanthine Oxidase
Concept	Zidovudine
Concept	HLA-B Antigens
Concept	Sulfotransferases
Concept	Arylsulfotransferase
Concept	Deoxyribonucleases, Type II Site-Specific
Concept	Xenobiotics
Concept	Citalopram
Concept	RNA Probes
Concept	Gene Library
Concept	Minor Histocompatibility Antigens
Concept	Interleukin-6
Concept	Tacrolimus
Concept	Cyclosporine
Concept	Bupropion
Concept	NAD(P)H Dehydrogenase (Quinone)
Concept	Fluvoxamine
Concept	Cyclooxygenase Inhibitors
Concept	Drug Monitoring
Concept	Pravastatin
Concept	Ondansetron
Concept	HIV Protease Inhibitors
Concept	Paroxetine
Concept	Alternative Splicing
Concept	Receptors, Opioid, mu
Concept	DNA Primers
Concept	DNA, Complementary
Concept	Antidepressive Agents, Second-Generation
Concept	Excitatory Amino Acid Antagonists
Concept	Analgesics, Non-Narcotic
Concept	Adrenergic Uptake Inhibitors
Concept	Antineoplastic Agents, Hormonal
Concept	Risperidone
Concept	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Concept	Anti-HIV Agents
Concept	Human Growth Hormone
Concept	Cytochrome P-450 CYP1A2
Concept	Cytochrome P-450 CYP2D6
Concept	Cytochrome P-450 CYP2E1
Concept	Ritonavir
Concept	Intramolecular Oxidoreductases
Concept	Simvastatin
Concept	Tandem Repeat Sequences
Concept	Natriuretic Peptide, Brain
Concept	Sertraline
Concept	3' Untranslated Regions
Concept	Glucuronides
Concept	DNA, Intergenic
Concept	Amino Acid Transport Systems
Concept	Amino Acid Transport System A
Concept	Multidrug Resistance-Associated Proteins
Concept	Organic Cation Transporter 1
Concept	Organic Anion Transporters, Sodium-Independent
Concept	Drosophila Proteins
Concept	MicroRNAs
Concept	Steroid 16-alpha-Hydroxylase
Concept	Dihydrouracil Dehydrogenase (NADP)
Concept	Carboxylesterase
Concept	Benzoxazines
Concept	Serotonin Plasma Membrane Transport Proteins
Concept	Cytochrome P-450 CYP3A
Concept	Hepatocyte Nuclear Factor 4
Concept	Oseltamivir
Concept	2-Pyridinylmethylsulfinylbenzimidazoles
Concept	Proton Pump Inhibitors
Concept	Drug Dosage Calculations
Concept	Prescription Drugs
Concept	Serotonin 5-HT3 Receptor Agonists
Concept	Lopinavir
Concept	Sulfonylurea Receptors
Concept	Vitamin K Epoxide Reductases
Concept	Drug-Related Side Effects and Adverse Reactions
Concept	Cytochrome P-450 Enzyme Inhibitors
Concept	Cytochrome P-450 CYP2A6
Concept	Cytochrome P-450 CYP2D6 Inhibitors
Concept	Cytochrome P-450 CYP2B6 Inducers
Concept	Cytochrome P-450 CYP2B6
Concept	Cytochrome P-450 CYP2C8
Concept	Cytochrome P-450 CYP2C9
Concept	Cytochrome P-450 CYP2C19
Academic Article	Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine.
Academic Article	CYP2D6 inhibition by selective serotonin reuptake inhibitors: analysis of achievable steady-state plasma concentrations and the effect of ultrarapid metabolism at CYP2D6.
Academic Article	Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Academic Article	Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction.
Academic Article	Lack of weight-based dose dependency and intraindividual variability of omeprazole for CYP2C19 phenotyping.
Academic Article	Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Academic Article	Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Academic Article	Multiple dose pharmacokinetics of paroxetine in children and adolescents with major depressive disorder or obsessive-compulsive disorder.
Academic Article	CYP2D636 gene arrangements within the cyp2d6 locus: association of CYP2D636 with poor metabolizer status.
Academic Article	Comments on Hoskins et al. [(2005) drug metab dispos 33:1564-1565].
Academic Article	Maribavir pharmacokinetics and the effects of multiple-dose maribavir on cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2, and xanthine oxidase activities in healthy adults.
Academic Article	Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity.
Academic Article	Effect of arylamine acetyltransferase Nat3 gene knockout on N-acetylation in the mouse.
Academic Article	Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects.
Academic Article	Genetic determinants of variable metabolism have little impact on the clinical use of leading antipsychotics in the CATIE study.
Academic Article	Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions.
Academic Article	Variability in drug metabolizing enzyme activity in HIV-infected patients.
Academic Article	Impact of the CYP2C19*17 allele on the pharmacokinetics of omeprazole and pantoprazole in children: evidence for a differential effect.
Academic Article	Genetic variants of the drug-metabolizing enzyme CYP2D6 in Puerto Rican psychiatry patients: a preliminary report and potential implications for breast cancer patients.
Academic Article	Genetic transmission of cytochrome P450 2D6 (CYP2D6) ultrarapid metabolism: implications for breastfeeding women taking codeine.
Academic Article	Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype.
Academic Article	In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4a expression.
Academic Article	Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants.
Academic Article	Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.
Academic Article	Epitope mapping studies with human anti-cytochrome P450 3A antibodies.
Academic Article	Regulation of microRNA expression by rifampin in human hepatocytes.
Academic Article	Challenges in CYP2D6 phenotype assignment from genotype data: a critical assessment and call for standardization.
Academic Article	Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.
Academic Article	Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
Academic Article	In vivo characterization of CYP2D612, 29 and *84 using dextromethorphan as a probe drug: a case report.
Academic Article	Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article	CYP450 genotype and pharmacogenetic association studies: a critical appraisal.
Academic Article	Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article	Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes.
Academic Article	Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.
Academic Article	Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.
Academic Article	Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
Academic Article	Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and use of ondansetron and tropisetron.
Academic Article	Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.
Academic Article	Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.
Academic Article	Precision medicine: does ethnicity information complement genotype-based prescribing decisions?
Academic Article	Impact of CYP2D6 on venlafaxine metabolism in Trinidadian patients with major depressive disorder.
Academic Article	Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article	Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.
Academic Article	Dose dependency of dextromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyping.
Academic Article	Interethnic differences of drug-metabolizing enzymes.
Academic Article	Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
Academic Article	Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Academic Article	Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Academic Article	The Case for Pharmacogenetics-Guided Prescribing of Codeine in Children.
Academic Article	Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Academic Article	Pharmacogenetics: Chasing Perfection.
Grant	PBPK prediction of ontogeny mediated alteration in hepatic drug elimination
Grant	Ontogeny of Drug Bioactivation and Idiosyncratic ADRs
Grant	Regulation of drug metabolizing enzymes by miRNAs
Grant	Metabolism and toxicity of preterm infants
Grant	Regulation of drug metabolizing enzymes by miRNAs
Academic Article	CRC Press/Taylor & Francis Group, Ye, S.Q. (ed.)
Academic Article	A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Academic Article	Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2C9 and Nonsteroidal Anti-Inflammatory Drugs.
Academic Article	The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites.
Academic Article	Retrospective Review of Pharmacogenetic Testing at an Academic Children's Hospital.
Academic Article	Review and Consensus on Pharmacogenomic Testing in Psychiatry.
Academic Article	Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
Academic Article	Ten Years of Experience Support Pharmacogenetic Testing to Guide Individualized Drug Therapy.
Academic Article	Developmental pharmacokinetics of indomethacin in preterm neonates: Severely decreased drug clearance in the first week of life.
Academic Article	Pharmacogenomic variation in the Malagasy population: implications for the antimalarial drug primaquine metabolism.

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