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research overview Dr. Bradley's research group seeks to understand how immune responses are regulated and to use these tools to engineer immunity. Dysregulation of the immune system can result in an over-stimulated immune response as observed in allergy and autoimmune disorders, or a poor immune response that results in susceptibility to infection and cancer. Dr. Bradley uses genomic technologies to dissect the molecular and cellular mechanisms that shape the immune response and determine how human genetics impacts an individual immunity in order to identify biomarkers and pathways that can be targeted to improve immunotherapies and vaccines. Prior to joining Children's Mercy, Dr. Bradley was Director of Viral Genetic Analysis and Assistant Professor of Medicine at the Human Vaccine Institute at the Duke University Medical Center.

One or more keywords matched the following items that are connected to Bradley, Todd

Item TypeName
Concept Adolescent
Concept Vaccines
Concept AIDS Vaccines
Concept Vaccines, Subunit
Academic Article Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.
Academic Article Immunogenicity of NYVAC Prime-Protein Boost Human Immunodeficiency Virus Type 1 Envelope Vaccination and Simian-Human Immunodeficiency Virus Challenge of Nonhuman Primates.
Academic Article Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge.
Academic Article Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved.
Academic Article Broadly Neutralizing Antibodies and the Development of Vaccines.
Academic Article Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Academic Article Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.
Academic Article Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages.
Academic Article Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity.
Academic Article HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism.
Academic Article Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.
Academic Article A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge.
Academic Article Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV.
Academic Article RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.
Academic Article Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.
Academic Article Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization.
Academic Article Immune checkpoint modulation enhances HIV-1 antibody induction.
Academic Article Antibody Responses after a Single Dose of SARS-CoV-2 mRNA Vaccine.
Academic Article Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.
Academic Article Cross-reactive antibody immunity against SARS-CoV-2 in children and adults.
Academic Article Humoral immune responses during SARS-CoV-2 mRNA vaccine administration in seropositive and seronegative individuals.
Academic Article Immune cell residency in the nasal mucosa may partially explain respiratory disease severity across the age range.

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  • Adolescent
  • vaccines