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research overview Dr. Elin Grundberg completed her PhD (2006) in Molecular Medicine at Uppsala University, Sweden and following post-doctoral training at the McGill University and Genome Quebec Innovation Centre she joined Wellcome Trust Sanger institute in 2009 to lead the international MuTHER Consortium, which included developing a major resource of detailed genomics and epigenomics data from multiple disease-targeted tissues from twins. In 2012, she was appointed Tenure-Track Assistant Professor at the Department of Human Genetics at McGill University where her group was applying various next-generation sequencing approaches to understand genetic and epigenetic factors underlying complex disease susceptibility. Dr. Grundberg lead two CIHR team grants on this topic including the EpiTriO Consotium with partners in Canada and Europe. She held a Canada Research Chair (tier 2) in Disease Genomics and Epigenomics. In Oct 2017, Dr. Grundberg joined the faculty at Children’s Mercy Kansas City where she holds the Roberta D. Harding & William F. Bradley, Jr. Endowed Chair in Genomic Research. She is building a comprehensive research program leveraging international collaborations (King’s College London, UK; INSERM, France, Helmholtz Zentrum, Germany, McGill, Canada) as well as local collaborators (CM, UMKC, KUMC) for tissue-resources and methodologies essential for contemporary disease genomics and epigenomics. Research areas span genomics medicine applied in pediatric and adult populations including rare diseases, metabolic diseases, social and environmental health and perinatal/maternal health. Dr. Grundberg currently collaborates with a number of large international research consortia and is the author of over 75 scientific papers.

One or more keywords matched the following items that are connected to Grundberg, Elin

Item TypeName
Concept Age Factors
Concept Chromosomes, Human, Pair 14
Concept Chromosomes, Human, Pair 17
Concept Chromosomes, Human, Pair 3
Concept Fibroblast Growth Factors
Concept Humans
Concept Risk Factors
Concept Transcription Factors
Concept Genome, Human
Concept Guanine Nucleotide Exchange Factors
Concept Interferon Regulatory Factors
Concept Sp Transcription Factors
Concept Kruppel-Like Transcription Factors
Concept Basic Helix-Loop-Helix Transcription Factors
Academic Article Vitamin D receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the MrOS Study in Sweden and Hong Kong.
Academic Article Systematic assessment of the human osteoblast transcriptome in resting and induced primary cells.
Academic Article A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.
Academic Article Targeted screening of cis-regulatory variation in human haplotypes.
Academic Article Spectrum of mutations in MMACHC, allelic expression, and evidence for genotype-phenotype correlations.
Academic Article Common sequence variation in FLNB regulates bone structure in women in the general population and FLNB mRNA expression in osteoblasts in vitro.
Academic Article Population genomics in a disease targeted primary cell model.
Academic Article Tissue effect on genetic control of transcript isoform variation.
Academic Article Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.
Academic Article Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
Academic Article Global patterns of cis variation in human cells revealed by high-density allelic expression analysis.
Academic Article A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.
Academic Article Cell culture-induced aberrant methylation of the imprinted IG DMR in human lymphoblastoid cell lines.
Academic Article Analysis of the impact of genetic variation on human gene expression.
Academic Article An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.
Academic Article Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Academic Article Global analysis of the impact of environmental perturbation on cis-regulation of gene expression.
Academic Article Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
Academic Article Assessment of gene-by-sex interaction effect on bone mineral density.
Academic Article Large-scale association analysis identifies new risk loci for coronary artery disease.
Academic Article An epigenome-wide association study of total serum immunoglobulin E concentration.
Academic Article Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants.
Academic Article Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts.
Academic Article Global miRNA expression and correlation with mRNA levels in primary human bone cells.
Academic Article Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.
Academic Article Population whole-genome bisulfite sequencing across two tissues highlights the environment as the principal source of human methylome variation.
Academic Article Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome.
Academic Article Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements.
Academic Article A poly adenosine repeat in the human vitamin D receptor gene is associated with bone mineral density in young Swedish women.
Academic Article Genetic variation in the human vitamin D receptor is associated with muscle strength, fat mass and body weight in Swedish women.
Academic Article A deletion polymorphism in the RIZ gene, a female sex steroid hormone receptor coactivator, exhibits decreased response to estrogen in vitro and associates with low bone mineral density in young Swedish women.
Academic Article A TA-repeat polymorphism in the gene for the estrogen receptor alpha does not correlate with muscle strength or body composition in young adult Swedish women.
Academic Article The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor.
Academic Article Novel estrogen receptor alpha promoter polymorphism increases ventricular hypertrophic response to hypertension.
Academic Article The impact of estradiol on bone mineral density is modulated by the specific estrogen receptor-alpha cofactor retinoblastoma-interacting zinc finger protein-1 insertion/deletion polymorphism.
Academic Article A genome-wide approach to identifying novel-imprinted genes.
Academic Article The COMT val158met polymorphism is associated with prevalent fractures in Swedish men.
Academic Article Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men.
Academic Article Fibroblast growth factor-23 is associated with parathyroid hormone and renal function in a population-based cohort of elderly men.
Academic Article IL6 and IL1B polymorphisms are associated with fat mass in older men: the MrOS Study Sweden.
Academic Article Type I collagen alpha1 Sp1 polymorphism and the risk of cruciate ligament ruptures or shoulder dislocations.
Academic Article Estimation of physical performance and measurements of habitual physical activity may capture men with high risk to fall--data from the Mr Os Sweden cohort.
Academic Article The architecture of gene regulatory variation across multiple human tissues: the MuTHER study.
Academic Article Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
Academic Article Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes.
Academic Article Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
Academic Article Human metabolic individuality in biomedical and pharmaceutical research.
Academic Article Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.
Academic Article Impact of common variation in bone-related genes on type 2 diabetes and related traits.
Academic Article Mapping cis- and trans-regulatory effects across multiple tissues in twins.
Academic Article A comparison of the whole genome approach of MeDIP-seq to the targeted approach of the Infinium HumanMethylation450 BeadChip(®) for methylome profiling.
Academic Article The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue.
Academic Article Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.
Academic Article Gene expression changes with age in skin, adipose tissue, blood and brain.
Academic Article Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements.
Academic Article Expression of phosphofructokinase in skeletal muscle is influenced by genetic variation and associated with insulin sensitivity.
Academic Article Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Academic Article An atlas of genetic influences on human blood metabolites.
Academic Article Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
Academic Article Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.
Academic Article Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation.
Academic Article Whole-genome sequence-based analysis of thyroid function.
Academic Article Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36.
Academic Article Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis.
Academic Article Identification of Novel Loci Associated With Hip Shape: A Meta-Analysis of Genomewide Association Studies.
Academic Article Variations in the vitamin D receptor gene are not associated with measures of muscle strength, physical performance, or falls in elderly men. Data from MrOS Sweden.
Academic Article An atlas of genetic influences on osteoporosis in humans and mice.
Academic Article Author Correction: An atlas of genetic influences on osteoporosis in humans and mice.
Academic Article UCP1 expression-associated gene signatures of human epicardial adipose tissue.
Academic Article Correction to: Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome.
Academic Article Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures.
Academic Article Customized MethylC-Capture Sequencing to Evaluate Variation in the Human Sperm DNA Methylome Representative of Altered Folate Metabolism.
Grant Environmental Exposures, AHR Activation, and Placental Origins of Development
Grant Obesity Genes, Energy Regulation in Response to Weight-Loss Diets
Academic Article Capturing functional epigenomes for insight into metabolic diseases.
Academic Article Single-cell analysis of human adipose tissue identifies depot and disease specific cell types.
Grant Understanding Mechanisms Underlying Chronic Stress-Induced Asthma in Children by Population and Single-Cell Epigenomics Approaches
Academic Article ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development.
Academic Article AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants.
Academic Article Antibody Responses after a Single Dose of SARS-CoV-2 mRNA Vaccine.
Academic Article Humoral immune responses during SARS-CoV-2 mRNA vaccine administration in seropositive and seronegative individuals.
Academic Article Immune cell residency in the nasal mucosa may partially explain respiratory disease severity across the age range.
Academic Article Intersection of regulatory pathways controlling hemostasis and hemochorial placentation.
Academic Article Blood DNA methylation at TXNIP and glycemic changes in response to weight-loss diet interventions: the POUNDS lost trial.
Academic Article Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes.
Academic Article Cross-reactive antibodies elicited to conserved epitopes on SARS-CoV-2 spike protein after infection and vaccination.
Academic Article Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers.

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