D002843AnatomyChemicals & DrugsPhysiologyA11.284.430.106.279.345.190.160.180D12.776.664.224G05.360.160.18010290.969052Chromatincmhprofilesont:personsuffixperson suffixFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentDivisionvivo:hrJobTitleHR job titleInformation Resourcevivo:orcidIdORCID idPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonMD, PhDTomiPastinenTomi Pastinen0.000000000000000.00000000000000113Pastinen, TomiDirector, Center for Pediatric Genomic Medicine 2Associate Professor1Professor25055051Light N, Adoue V, Ge B, Chen SH, Kwan T, Pastinen TEpigeneticsLight N, Adoue V, Ge B, Chen SH, Kwan T, Pastinen T. Interrogation of allelic chromatin states in human cells by high-density ChIP-genotyping. Epigenetics. 2014 Sep; 9(9):1238-51.Epigenetics2014-07-23T00:00:002014Interrogation of allelic chromatin states in human cells by high-density ChIP-genotyping.30890717Harutyunyan AS, Krug B, Chen H, Papillon-Cavanagh S, Zeinieh M, De Jay N, Deshmukh S, Chen CCL, Belle J, Mikael LG, Marchione DM, Li R, Nikbakht H, Hu B, Cagnone G, Cheung WA, Mohammadnia A, Bechet D, Faury D, McConechy MK, Pathania M, Jain SU, Ellezam B, Weil AG, Montpetit A, Salomoni P, Pastinen T, Lu C, Lewis PW, Garcia BA, Kleinman CL, Jabado N, Majewski JNature communicationsHarutyunyan AS, Krug B, Chen H, Papillon-Cavanagh S, Zeinieh M, De Jay N, Deshmukh S, Chen CCL, Belle J, Mikael LG, Marchione DM, Li R, Nikbakht H, Hu B, Cagnone G, Cheung WA, Mohammadnia A, Bechet D, Faury D, McConechy MK, Pathania M, Jain SU, Ellezam B, Weil AG, Montpetit A, Salomoni P, Pastinen T, Lu C, Lewis PW, Garcia BA, Kleinman CL, Jabado N, Majewski J. H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis. Nat Commun. 2019 03 19; 10(1):1262.Nat Commun2019-03-19T00:00:002019H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.28973438Younger ST, Rinn JLNucleic acids researchYounger ST, Rinn JL. p53 regulates enhancer accessibility and activity in response to DNA damage. Nucleic Acids Res. 2017 Sep 29; 45(17):9889-9900.Nucleic Acids Res2017-09-29T00:00:002017p53 regulates enhancer accessibility and activity in response to DNA damage.PhDScottYoungerScott T. Younger0.000000000000000.00000000000000137Younger, Scott0000-0002-6237-445XDirector of Disease Gene Engineering, Center for Pediatric Genomic MedicinePhDElinGrundbergElin Grundberg0.000000000000000.00000000000000138Grundberg, Elin0000-0001-5415-7896Roberta D. Harding & William F. Bradley Jr. Endowed Chair in Genomic Research PediatricsResearchClinicalChildren's Mercy Kansas CityMD, MSRobertLaneRobert H. Lane0.000000000000000.00000000000000179Lane, RobertExecutive Vice President/Physician-in-Chief26172404Suter MA, Abramovici AR, Griffin E, Branch DW, Lane RH, Mastrobattista J, Rehan VK, Aagaard KBirth defects research. Part A, Clinical and molecular teratologySuter MA, Abramovici AR, Griffin E, Branch DW, Lane RH, Mastrobattista J, Rehan VK, Aagaard K. In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model. Birth Defects Res A Clin Mol Teratol. 2015 Jul; 103(7):583-8.Birth Defects Res A Clin Mol Teratol2015-07-14T00:00:002015In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model.37563143Varberg KM, Dominguez EM, Koseva B, Varberg JM, McNally RP, Moreno-Irusta A, Wesley ER, Iqbal K, Cheung WA, Schwendinger-Schreck C, Smail C, Okae H, Arima T, Lydic M, Holoch K, Marsh C, Soares MJ, Grundberg ENature communicationsVarberg KM, Dominguez EM, Koseva B, Varberg JM, McNally RP, Moreno-Irusta A, Wesley ER, Iqbal K, Cheung WA, Schwendinger-Schreck C, Smail C, Okae H, Arima T, Lydic M, Holoch K, Marsh C, Soares MJ, Grundberg E. Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape. Nat Commun. 2023 08 10; 14(1):4826.Nat Commun2023-08-10T00:00:002023Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape.PhDKaelaVarbergKaela M Varberg0.000000000000000.00000000000000220Varberg, Kaela0000-0001-9672-4158Independent Investigatortrue1Director of Disease Gene Engineering, Center for Pediatric Genomic MedicineDirector of Disease Gene Engineering, Center for Pediatric Genomic Medicinetrue1Director, Center for Pediatric Genomic Medicine Director, Center for Pediatric Genomic Medicine true1Independent InvestigatorIndependent Investigatortrue1Roberta D. Harding & William F. Bradley Jr. Endowed Chair in Genomic Research Roberta D. Harding & William F. Bradley Jr. Endowed Chair in Genomic Research true1Executive Vice President/Physician-in-ChiefExecutive Vice President/Physician-in-Chief1.465280.02800810research area of0.9576540.063504326subject area for