Primary biliary cirrhosis is associated with a genetic variant in the 3' flanking region of the CTLA4 gene.
Juran BD, Atkinson EJ, Schlicht EM, Fridley BL, Lazaridis KN. Primary biliary cirrhosis is associated with a genetic variant in the 3' flanking region of the CTLA4 gene. Gastroenterology. 2008 Oct; 135(4):1200-6.