D053823Chemicals & DrugsD12.644.276.671D12.776.467.671D23.529.671450.997645Hedgehog Proteinscmhprofilesont:personsuffixperson suffixFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentDivisionvivo:hrJobTitleHR job titleInformation Resourcevivo:orcidIdORCID idPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson29437795Gordon RE, Zhang L, Peri S, Kuo YM, Du F, Egleston BL, Ng JMY, Andrews AJ, Astsaturov I, Curran T, Yang ZJClinical cancer research : an official journal of the American Association for Cancer ResearchGordon RE, Zhang L, Peri S, Kuo YM, Du F, Egleston BL, Ng JMY, Andrews AJ, Astsaturov I, Curran T, Yang ZJ. Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma. Clin Cancer Res. 2018 03 15; 24(6):1375-1388.Clin Cancer Res2018-02-06T00:00:002018Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma.3Assistant Professor2Associate Professor1ProfessorSurgery0.1964420.02937884research area of0.8129850.058041329subject area forPediatricsResearchClinicalChildren's Mercy Kansas CityMDCharlesSnyderCharles L. Snyder0.000000000000000.00000000000000158Snyder, CharlesChief, Section of Pediatric Surgery MDKevinGinnKevin F. Ginn0.000000000000000.00000000000000176Ginn, KevinNeuro-Oncologist and Director, Pediatric Brain Tumor ProgramMD, FAAP, FACMG, CCDEricRushEric T. Rush0.000000000000000.00000000000000200Rush, Eric0000-0002-8147-7315Medical Director, Office of Faculty Affairs and DevelopmentPhDJayVivianJay Vivian0.000000000000000.00000000000000206Vivian, Jay0000-0001-5375-5974Director, Rare Disease Model Research Program32167205Wang W, Allard BA, Pottorf TS, Wang HH, Vivian JL, Tran PVFASEB journal : official publication of the Federation of American Societies for Experimental BiologyWang W, Allard BA, Pottorf TS, Wang HH, Vivian JL, Tran PV. Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis. FASEB J. 2020 05; 34(5):6369-6381.FASEB J2020-03-13T00:00:002020Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis.33200460Bosakova M, Abraham SP, Nita A, Hruba E, Buchtova M, Taylor SP, Duran I, Martin J, Svozilova K, Barta T, Varecha M, Balek L, Kohoutek J, Radaszkiewicz T, Pusapati GV, Bryja V, Rush ET, Thiffault I, Nickerson DA, Bamshad MJ, Rohatgi R, Cohn DH, Krakow D, Krejci PEMBO molecular medicineBosakova M, Abraham SP, Nita A, Hruba E, Buchtova M, Taylor SP, Duran I, Martin J, Svozilova K, Barta T, Varecha M, Balek L, Kohoutek J, Radaszkiewicz T, Pusapati GV, Bryja V, Rush ET, Thiffault I, Nickerson DA, Bamshad MJ, Rohatgi R, Cohn DH, Krakow D, Krejci P. Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling. EMBO Mol Med. 2020 11 06; 12(11):e11739.EMBO Mol Med2020-10-14T00:00:002020Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling.33649536Fan Q, Gong T, Zheng C, Ng JMY, Chen J, Myers C, Hensley H, Curran T, Yang ZJOncogeneFan Q, Gong T, Zheng C, Ng JMY, Chen J, Myers C, Hensley H, Curran T, Yang ZJ. Statins repress hedgehog signaling in medulloblastoma with no bone toxicities. Oncogene. 2021 03; 40(12):2258-2272.Oncogene2021-03-01T00:00:002021Statins repress hedgehog signaling in medulloblastoma with no bone toxicities.33789113Dang MT, Gonzalez MV, Gaonkar KS, Rathi KS, Young P, Arif S, Zhai L, Alam Z, Devalaraja S, To TKJ, Folkert IW, Raman P, Rokita JL, Martinez D, Taroni JN, Shapiro JA, Greene CS, Savonen C, Mafra F, Hakonarson H, Curran T, Haldar MCell reportsDang MT, Gonzalez MV, Gaonkar KS, Rathi KS, Young P, Arif S, Zhai L, Alam Z, Devalaraja S, To TKJ, Folkert IW, Raman P, Rokita JL, Martinez D, Taroni JN, Shapiro JA, Greene CS, Savonen C, Mafra F, Hakonarson H, Curran T, Haldar M. Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality. Cell Rep. 2021 03 30; 34(13):108917.Cell Rep2021-03-30T00:00:002021Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality.true1Director, Rare Disease Model Research ProgramDirector, Rare Disease Model Research Programtrue1Chief, Section of Pediatric Surgery Chief, Section of Pediatric Surgery true1Medical Director, Office of Faculty Affairs and DevelopmentMedical Director, Office of Faculty Affairs and Developmenttrue1Neuro-Oncologist and Director, Pediatric Brain Tumor ProgramNeuro-Oncologist and Director, Pediatric Brain Tumor Program