D020868PhysiologyG05.355.315.203.3748130.993073Gene Silencingcmhprofilesont:personsuffixperson suffixFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentDivisionvivo:hrJobTitleHR job titleInformation Resourcevivo:orcidIdORCID idPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson3Assistant Professor2Associate Professor1Professor0.5202670.02314938research area of0.6259090.079760313subject area for20675357Chu Y, Yue X, Younger ST, Janowski BA, Corey DRNucleic acids researchChu Y, Yue X, Younger ST, Janowski BA, Corey DR. Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter. Nucleic Acids Res. 2010 Nov; 38(21):7736-48.Nucleic Acids Res2010-07-30T00:00:002010Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter.21427083Younger ST, Corey DRNucleic acids researchYounger ST, Corey DR. Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters. Nucleic Acids Res. 2011 Jul; 39(13):5682-91.Nucleic Acids Res2011-03-22T00:00:002011Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters.PhDScottYoungerScott T. Younger0.000000000000000.00000000000000137Younger, Scott0000-0002-6237-445XDirector of Disease Gene Engineering, Center for Pediatric Genomic MedicinePediatricsResearchClinicalChildren's Mercy Kansas CityMDKevinGinnKevin F. Ginn0.000000000000000.00000000000000176Ginn, KevinNeuro-Oncologist and Director, Pediatric Brain Tumor ProgramPhDJayVivianJay Vivian0.000000000000000.00000000000000206Vivian, Jay0000-0001-5375-5974Director, Rare Disease Model Research ProgramMD, PhDTomooIwakumaTomoo Iwakuma0.000000000000000.00000000000000207Iwakuma, Tomoo0000-0001-7249-7958Professor and Director, Translational Laboratory Oncology Research28636657Kundu AK, Iyer SV, Chandra S, Adhikari AS, Iwakuma T, Mandal TKPloS oneKundu AK, Iyer SV, Chandra S, Adhikari AS, Iwakuma T, Mandal TK. Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma. PLoS One. 2017; 12(6):e0179168.PLoS One2017-06-21T00:00:002017Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma.30674441Han Y, Wu P, Wang Z, Zhang Z, Sun S, Liu J, Gong S, Gao P, Iwakuma T, Molina-Vila MA, Chen BP, Zhang Y, Ji T, Mo Q, Chen P, Hu J, Wang S, Zhou J, Lu H, Gao QEBioMedicineHan Y, Wu P, Wang Z, Zhang Z, Sun S, Liu J, Gong S, Gao P, Iwakuma T, Molina-Vila MA, Chen BP, Zhang Y, Ji T, Mo Q, Chen P, Hu J, Wang S, Zhou J, Lu H, Gao Q. Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation. EBioMedicine. 2019 Feb; 40:92-105.EBioMedicine2019-01-20T00:00:002019Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.true1Director, Rare Disease Model Research ProgramDirector, Rare Disease Model Research ProgramPhDBrookeFridleyBrooke Fridley0.000000000000000.00000000000000222Fridley, BrookeDirector, Biostatistics and Epidemiology Core23571109Cicek MS, Koestler DC, Fridley BL, Kalli KR, Armasu SM, Larson MC, Wang C, Winham SJ, Vierkant RA, Rider DN, Block MS, Klotzle B, Konecny G, Winterhoff BJ, Hamidi H, Shridhar V, Fan JB, Visscher DW, Olson JE, Hartmann LC, Bibikova M, Chien J, Cunningham JM, Goode ELHuman molecular geneticsCicek MS, Koestler DC, Fridley BL, Kalli KR, Armasu SM, Larson MC, Wang C, Winham SJ, Vierkant RA, Rider DN, Block MS, Klotzle B, Konecny G, Winterhoff BJ, Hamidi H, Shridhar V, Fan JB, Visscher DW, Olson JE, Hartmann LC, Bibikova M, Chien J, Cunningham JM, Goode EL. Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel. Hum Mol Genet. 2013 Aug 01; 22(15):3038-47.Hum Mol Genet2013-04-09T00:00:002013Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel.true1Director, Biostatistics and Epidemiology CoreDirector, Biostatistics and Epidemiology Coretrue1Director of Disease Gene Engineering, Center for Pediatric Genomic MedicineDirector of Disease Gene Engineering, Center for Pediatric Genomic Medicinetrue1Professor and Director, Translational Laboratory Oncology ResearchProfessor and Director, Translational Laboratory Oncology Researchtrue1Neuro-Oncologist and Director, Pediatric Brain Tumor ProgramNeuro-Oncologist and Director, Pediatric Brain Tumor Program