D016159Chemicals & DrugsD12.776.260.820D12.776.624.776.775D12.776.660.825D12.776.744.8456450.942064Tumor Suppressor Protein p53cmhprofilesont:personsuffixperson suffixFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentDivisionvivo:hrJobTitleHR job titleInformation Resourcevivo:orcidIdORCID idPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson8.758590.07823876research area of0.9854940.032858655subject area for3Assistant Professor1ProfessorPhDScottYoungerScott T. Younger0.000000000000000.00000000000000137Younger, Scott0000-0002-6237-445XDirector of Disease Gene Engineering, Center for Pediatric Genomic MedicinePediatricsResearchClinicalChildren's Mercy Kansas City32005150Borys SM, Younger STBMC genomicsBorys SM, Younger ST. Identification of functional regulatory elements in the human genome using pooled CRISPR screens. BMC Genomics. 2020 Jan 31; 21(1):107.BMC Genomics2020-01-31T00:00:002020Identification of functional regulatory elements in the human genome using pooled CRISPR screens.MD, MSRobertLaneRobert H. Lane0.000000000000000.00000000000000179Lane, RobertExecutive Vice President/Physician-in-ChiefMD, PhDTomooIwakumaTomoo Iwakuma0.000000000000000.00000000000000207Iwakuma, Tomoo0000-0001-7249-7958Professor and Director, Translational Laboratory Oncology Research33545063Ghosh M, Saha S, Bettke J, Nagar R, Parrales A, Iwakuma T, van der Velden AWM, Martinez LACancer cellGhosh M, Saha S, Bettke J, Nagar R, Parrales A, Iwakuma T, van der Velden AWM, Martinez LA. Mutant p53 suppresses innate immune signaling to promote tumorigenesis. Cancer Cell. 2021 04 12; 39(4):494-508.e5.Cancer Cell2021-02-04T00:00:002021Mutant p53 suppresses innate immune signaling to promote tumorigenesis.34183772Kaida A, Yamamoto S, Parrales A, Young ED, Ranjan A, Alalem MA, Morita KI, Oikawa Y, Harada H, Ikeda T, Thomas SM, Diaz FJ, Iwakuma TOncogeneKaida A, Yamamoto S, Parrales A, Young ED, Ranjan A, Alalem MA, Morita KI, Oikawa Y, Harada H, Ikeda T, Thomas SM, Diaz FJ, Iwakuma T. DNAJA1 promotes cancer metastasis through interaction with mutant p53. Oncogene. 2021 08; 40(31):5013-5025.Oncogene2021-06-28T00:00:002021DNAJA1 promotes cancer metastasis through interaction with mutant p53.34948322Kaida A, Iwakuma TInternational journal of molecular sciencesKaida A, Iwakuma T. Regulation of p53 and Cancer Signaling by Heat Shock Protein 40/J-Domain Protein Family Members. Int J Mol Sci. 2021 Dec 16; 22(24).Int J Mol Sci2021-12-16T00:00:002021Regulation of p53 and Cancer Signaling by Heat Shock Protein 40/J-Domain Protein Family Members.Pathtology and Laboratory MedicineMD, PhD, MSPHJohnNolenJohn D Nolen0.000000000000000.00000000000000217Nolen, JohnChair, Department of Pathology and Laboratory Medicinetrue1Chair, Department of Pathology and Laboratory MedicineChair, Department of Pathology and Laboratory MedicinePhDBrookeFridleyBrooke Fridley0.000000000000000.00000000000000222Fridley, BrookeDirector, Biostatistics and Epidemiology Core38199451Kamath D, Iwakuma T, Bossmann SHNanomedicine : nanotechnology, biology, and medicineKamath D, Iwakuma T, Bossmann SH. Therapeutic potential of combating cancer by restoring wild-type p53 through mRNA nanodelivery. Nanomedicine. 2024 Feb; 56:102732.Nanomedicine2024-01-08T00:00:002024Therapeutic potential of combating cancer by restoring wild-type p53 through mRNA nanodelivery.true1Director, Biostatistics and Epidemiology CoreDirector, Biostatistics and Epidemiology Coretrue1Director of Disease Gene Engineering, Center for Pediatric Genomic MedicineDirector of Disease Gene Engineering, Center for Pediatric Genomic Medicinetrue1Professor and Director, Translational Laboratory Oncology ResearchProfessor and Director, Translational Laboratory Oncology Researchtrue1Executive Vice President/Physician-in-ChiefExecutive Vice President/Physician-in-Chief