D013379Concepts & IdeasG02.111.8355170.996279Substrate Specificitycmhprofilesont:personsuffixperson suffixFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentDivisionvivo:hrJobTitleHR job titleInformation Resourcevivo:orcidIdORCID idPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson26608082Pearce RE, Gaedigk R, Twist GP, Dai H, Riffel AK, Leeder JS, Gaedigk ADrug metabolism and disposition: the biological fate of chemicalsPearce RE, Gaedigk R, Twist GP, Dai H, Riffel AK, Leeder JS, Gaedigk A. Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation. Drug Metab Dispos. 2016 07; 44(7):948-58.Drug Metab Dispos2015-11-25T00:00:002015Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.26780308Shah RR, Gaedigk A, LLerena A, Eichelbaum M, Stingl J, Smith RLPharmacogenomicsShah RR, Gaedigk A, LLerena A, Eichelbaum M, Stingl J, Smith RL. CYP450 genotype and pharmacogenetic association studies: a critical appraisal. Pharmacogenomics. 2016 Feb; 17(3):259-75.Pharmacogenomics2016-01-18T00:00:002016CYP450 genotype and pharmacogenetic association studies: a critical appraisal.27052878Dinh JC, Pearce RE, Van Haandel L, Gaedigk A, Leeder JSDrug metabolism and disposition: the biological fate of chemicalsDinh JC, Pearce RE, Van Haandel L, Gaedigk A, Leeder JS. Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children. Drug Metab Dispos. 2016 07; 44(7):1070-9.Drug Metab Dispos2016-04-06T00:00:002016Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.0.3975110.01124235research area of0.1439150.026077418subject area for1Professor23DirectorSurgeryPediatricsResearchClinicalPhD, MSAndreaGaedigkAndrea Gaedigk39.08346750000000-94.577112900000001Gaedigk, Andrea0000-0001-6968-1893Director, Pharmacogenetics Core LaboratoryPharmD, PhDJ. StevenLeederJ. Steven Leeder39.08346750000000-94.5771129000000034Leeder, J. Steven0000-0001-6688-0504Deputy Director, Children's Research InstituteChildren's Mercy Kansas City21525169Parkinson A, Kazmi F, Buckley DB, Yerino P, Paris BL, Holsapple J, Toren P, Otradovec SM, Ogilvie BWDrug metabolism and disposition: the biological fate of chemicalsParkinson A, Kazmi F, Buckley DB, Yerino P, Paris BL, Holsapple J, Toren P, Otradovec SM, Ogilvie BW. An evaluation of the dilution method for identifying metabolism-dependent inhibitors of cytochrome P450 enzymes. Drug Metab Dispos. 2011 Aug; 39(8):1370-87.Drug Metab Dispos2011-04-27T00:00:002011An evaluation of the dilution method for identifying metabolism-dependent inhibitors of cytochrome P450 enzymes.MDCharlesSnyderCharles L. Snyder0.000000000000000.00000000000000158Snyder, CharlesChief, Section of Pediatric Surgery PhDPaulTorenPaul C. Toren0.000000000000000.00000000000000164Toren, PaulDirector, Analytical Chemistry CoreMD, MSRobertLaneRobert H. Lane0.000000000000000.00000000000000179Lane, RobertExecutive Vice President/Physician-in-Chief22982377Suter MA, Chen A, Burdine MS, Choudhury M, Harris RA, Lane RH, Friedman JE, Grove KL, Tackett AJ, Aagaard KMFASEB journal : official publication of the Federation of American Societies for Experimental BiologySuter MA, Chen A, Burdine MS, Choudhury M, Harris RA, Lane RH, Friedman JE, Grove KL, Tackett AJ, Aagaard KM. A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. FASEB J. 2012 Dec; 26(12):5106-14.FASEB J2012-09-14T00:00:002012A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.true1Director, Analytical Chemistry CoreDirector, Analytical Chemistry Coretrue1Chief, Section of Pediatric Surgery Chief, Section of Pediatric Surgery true1Director, Pharmacogenetics Core LaboratoryDirector, Pharmacogenetics Core Laboratorytrue1Deputy Director, Children's Research InstituteDeputy Director, Children's Research Institutetrue1Executive Vice President/Physician-in-ChiefExecutive Vice President/Physician-in-Chief