11061577Streetman DS, Bleakley JF, Kim JS, Nafziger AN, Leeder JS, Gaedigk A, Gotschall R, Kearns GL, Bertino JSClinical pharmacology and therapeuticsAryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Midazolam; Mixed Function Oxygenases; Omeprazole; Oxidoreductases, N-Demethylating; Xanthine OxidaseAdministration, Oral; Adult; Anti-Anxiety Agents; Anti-Ulcer Agents; Antitussive Agents; Central Nervous System Stimulants; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Combinations; Drug Interactions; Female; Genotype; Humans; Hypnotics and Sedatives; Male; Middle Aged; Phenotype; Polymerase Chain ReactionStreetman DS, Bleakley JF, Kim JS, Nafziger AN, Leeder JS, Gaedigk A, Gotschall R, Kearns GL, Bertino JS. Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail". Clin Pharmacol Ther. 2000 Oct; 68(4):375-83.Clin Pharmacol Ther2000-10-01T00:00:002000Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".cmhprofilesont:personsuffixperson suffixFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:orcidIdORCID idPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD008297Physiology11633280.54802MaleD008874Chemicals & Drugs3110.997377MidazolamD008875Concepts & IdeasLiving Beings836510.853398Middle AgedD009853Chemicals & Drugs3120.995816OmeprazoleD010089Chemicals & Drugs280.997794Oxidoreductases, N-DemethylatingD010641Physiology412440.921521PhenotypeAuthorship 1096Authorship 11050.04910520.04910522authors10.2530has subject areaD014151Chemicals & DrugsPhysiology450.998487Anti-Anxiety AgentsD014969Chemicals & Drugs2140.997053Xanthine OxidaseD016133Procedures25880.959798Polymerase Chain ReactionD019388Chemicals & Drugs2120.997554Cytochrome P-450 CYP1A2D019389Chemicals & Drugs91830.831211Cytochrome P-450 CYP2D61ProfessorD051544Chemicals & Drugs9460.961777Cytochrome P-450 CYP3AD000284Procedures23620.982389Administration, OralD065731Chemicals & Drugs12550.96451Cytochrome P-450 CYP2C19PediatricsResearchPhD, MSAndreaGaedigkAndrea Gaedigk39.08346750000000-94.577112900000001Gaedigk, Andrea0000-0001-6968-1893Director, Pharmacogenetics Core LaboratoryPharmD, PhDJ. StevenLeederJ. Steven Leeder39.08346750000000-94.5771129000000034Leeder, J. Steven0000-0001-6688-0504Deputy Director, Children's Research InstituteD000328Living Beings11012590.736773AdultChildren's Mercy Kansas CityD000697Chemicals & Drugs4100.99294Central Nervous System StimulantsD000897Chemicals & Drugs380.995727Anti-Ulcer AgentsD000996Chemicals & Drugs2130.995576Antitussive AgentsD001189Chemicals & Drugs5410.973439Aryl Hydrocarbon HydroxylasesD001191Chemicals & Drugs4180.995386Arylamine N-AcetyltransferaseD002110Chemicals & Drugs2120.996747Caffeinetrue1Director, Pharmacogenetics Core LaboratoryDirector, Pharmacogenetics Core Laboratorytrue1Deputy Director, Children's Research InstituteDeputy Director, Children's Research InstituteD003577Chemicals & Drugs6880.933256Cytochrome P-450 Enzyme SystemD003915Chemicals & Drugs4570.975487DextromethorphanD004338Chemicals & Drugs8180.996389Drug CombinationsD004347Physiology9300.989511Drug InteractionsD005260Physiology11835990.534568FemaleD005838Physiology404010.883905GenotypeD006801Living Beings12067970.397999HumansD006899Chemicals & Drugs2140.99561Mixed Function OxygenasesD006993Chemicals & DrugsPhysiology450.999496Hypnotics and Sedatives