27052878Dinh JC, Pearce RE, Van Haandel L, Gaedigk A, Leeder JSDrug metabolism and disposition: the biological fate of chemicalsAtomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Drug Dosage Calculations; Models, BiologicalAdolescent; Adult; Age Factors; Biotransformation; Child; Genotype; Humans; Hydroxylation; Infant; Isoenzymes; Methylation; Microsomes, Liver; Middle Aged; Phenols; Phenotype; Propylamines; Substrate Specificity; Young AdultDinh JC, Pearce RE, Van Haandel L, Gaedigk A, Leeder JS. Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children. Drug Metab Dispos. 2016 07; 44(7):1070-9.Drug Metab Dispos2016-04-06T00:00:002016Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.cmhprofilesont:personsuffixperson suffixFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:orcidIdORCID idPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD008745Phenomena7120.997141MethylationD008862Anatomy6420.967198Microsomes, LiverD008875Concepts & IdeasLiving Beings836510.853398Middle AgedD008954Concepts & IdeasDevices19460.964309Models, BiologicalD010636Chemicals & Drugs460.996699PhenolsD010641Physiology412440.921521PhenotypeD011437Chemicals & Drugs330.998955PropylaminesAuthorship 7604Authorship 761Authorship 76250.5756590.1439154authors10.2524has subject areaD013379Concepts & Ideas5170.996279Substrate Specificity1ProfessorD000069445390.9872Atomoxetine HydrochlorideD054796Concepts & IdeasProcedures10170.980165Drug Dosage CalculationsD055815Living Beings966650.815894Young AdultD000293Living Beings10621370.61882AdolescentPediatricsResearchPhD, MSAndreaGaedigkAndrea Gaedigk39.08346750000000-94.577112900000001Gaedigk, Andrea0000-0001-6968-1893Director, Pharmacogenetics Core LaboratoryPharmD, PhDJ. StevenLeederJ. Steven Leeder39.08346750000000-94.5771129000000034Leeder, J. Steven0000-0001-6688-0504Deputy Director, Children's Research InstituteD000328Living Beings11012590.736773AdultChildren's Mercy Kansas CityD000367Concepts & Ideas622150.934188Age FactorsAuthorship 7418D000697Chemicals & Drugs4100.99294Central Nervous System StimulantsD001289Disorders12180.975616Attention Deficit Disorder with HyperactivityD001711Physiology5490.980439Biotransformationtrue1Director, Pharmacogenetics Core LaboratoryDirector, Pharmacogenetics Core Laboratorytrue1Deputy Director, Children's Research InstituteDeputy Director, Children's Research InstituteD002648Living Beings11632570.520082ChildD003577Chemicals & Drugs6880.933256Cytochrome P-450 Enzyme SystemD005838Physiology404010.883905GenotypeD006801Living Beings12067970.397999HumansD006900Phenomena3120.996676HydroxylationD007223Living Beings9914490.693714InfantD007527Chemicals & Drugs7190.991311Isoenzymes