 Glomerulosclerosis, Focal Segmental
"Glomerulosclerosis, Focal Segmental" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
| Descriptor ID |
D005923
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| MeSH Number(s) |
C12.777.419.570.363.660 C13.351.968.419.570.363.640
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| Concept/Terms |
Glomerulosclerosis, Focal Segmental- Glomerulosclerosis, Focal Segmental
- Segmental Glomerulosclerosis, Focal
- Glomerulosclerosis, Focal
- Focal Glomerulosclerosis
- Focal Segmental Glomerulosclerosis
- Glomerulonephritis, Focal Sclerosing
- Focal Sclerosing Glomerulonephritides
- Focal Sclerosing Glomerulonephritis
- Glomerulonephritides, Focal Sclerosing
- Sclerosing Glomerulonephritides, Focal
- Sclerosing Glomerulonephritis, Focal
Hyalinosis, Segmental Glomerular- Hyalinosis, Segmental Glomerular
- Glomerular Hyalinosis, Segmental
- Segmental Glomerular Hyalinosis
- Hyalinosis, Segmental
- Segmental Hyalinosis
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Below are MeSH descriptors whose meaning is more general than "Glomerulosclerosis, Focal Segmental".
Below are MeSH descriptors whose meaning is more specific than "Glomerulosclerosis, Focal Segmental".
This graph shows the total number of publications written about "Glomerulosclerosis, Focal Segmental" by people in this website by year, and whether "Glomerulosclerosis, Focal Segmental" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1996 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 | | 2006 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2015 | 2 | 0 | 2 | | 2017 | 1 | 0 | 1 | | 2018 | 2 | 0 | 2 | | 2019 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2022 | 2 | 1 | 3 |
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Below are the most recent publications written about "Glomerulosclerosis, Focal Segmental" by people in Profiles.
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Gipson DS, Troost JP, Spino C, Attalla S, Tarnoff J, Massengill S, Lafayette R, Vega-Warner V, Adler S, Gipson P, Elliott M, Kaskel F, Fermin D, Moxey-Mims M, Fine RN, Brown EJ, Reidy K, Tuttle K, Gibson K, Lemley KV, Greenbaum LA, Atkinson MA, Hingorani S, Srivastava T, Sethna CB, Meyers K, Tran C, Dell KM, Wang CS, Yee JL, Sampson MG, Gbadegesin R, Lin JJ, Brady T, Rheault M, Trachtman H. Comparing Kidney Health Outcomes in Children, Adolescents, and Adults With Focal Segmental Glomerulosclerosis. JAMA Netw Open. 2022 08 01; 5(8):e2228701.
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Lieberman KV, Chang AR, Block GA, Robinson K, Bristow SL, Morales A, Mitchell A, McCalley S, McKay J, Pollak MR, Aradhya S, Warady BA. The KIDNEYCODE Program: Diagnostic Yield and Clinical Features of Individuals with CKD. Kidney360. 2022 05 26; 3(5):900-909.
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Lee AM, Hu J, Xu Y, Abraham AG, Xiao R, Coresh J, Rebholz C, Chen J, Rhee EP, Feldman HI, Ramachandran VS, Kimmel PL, Warady BA, Furth SL, Denburg MR. Using Machine Learning to Identify Metabolomic Signatures of Pediatric Chronic Kidney Disease Etiology. J Am Soc Nephrol. 2022 02; 33(2):375-386.
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Zee J, McNulty MT, Hodgin JB, Zhdanova O, Hingorani S, Jefferson JA, Gibson KL, Trachtman H, Fornoni A, Dell KM, Reich HN, Bagnasco S, Greenbaum LA, Lafayette RA, Gipson DS, Brown E, Kretzler M, Appel G, Sambandam KK, Tuttle KR, Chen D, Atkinson MA, Hogan MC, Kaskel FJ, Meyers KE, O'Toole J, Srivastava T, Sethna CB, Hladunewich MA, Lin JJ, Nast CC, Derebail VK, Patel J, Vento S, Holzman LB, Athavale AM, Adler SG, Lemley KV, Lieske JC, Hogan JJ, Gadegbeku CA, Fervenza FC, Wang CS, Matar RB, Singer P, Kopp JB, Barisoni L, Sampson MG. APOL1 genotype-associated morphologic changes among patients with focal segmental glomerulosclerosis. Pediatr Nephrol. 2021 09; 36(9):2747-2757.
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Sethna CB, Ng DK, Jiang S, Saland J, Warady BA, Furth S, Meyers KE. Cardiovascular disease risk among children with focal segmental glomerulosclerosis: a report from the chronic kidney disease in children study. Pediatr Nephrol. 2019 08; 34(8):1403-1412.
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Trachtman H, Nelson P, Adler S, Campbell KN, Chaudhuri A, Derebail VK, Gambaro G, Gesualdo L, Gipson DS, Hogan J, Lieberman K, Marder B, Meyers KE, Mustafa E, Radhakrishnan J, Srivastava T, Stepanians M, Tesar V, Zhdanova O, Komers R. DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS. J Am Soc Nephrol. 2018 11; 29(11):2745-2754.
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Pelletier JH, Kumar KR, Engen R, Bensimhon A, Varner JD, Rheault MN, Srivastava T, Straatmann C, Silva C, Davis TK, Wenderfer SE, Gibson K, Selewski D, Barcia J, Weng P, Licht C, Jawa N, Kallash M, Foreman JW, Wigfall DR, Chua AN, Chambers E, Hornik CP, Brewer ED, Nagaraj SK, Greenbaum LA, Gbadegesin RA. Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings. Pediatr Nephrol. 2018 10; 33(10):1773-1780.
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Savin VJ, Sharma M, Zhou J, Genochi D, Sharma R, Srivastava T, Ilahe A, Budhiraja P, Gupta A, McCarthy ET. Multiple Targets for Novel Therapy of FSGS Associated with Circulating Permeability Factor. Biomed Res Int. 2017; 2017:6232616.
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Trachtman H, Vento S, Herreshoff E, Radeva M, Gassman J, Stein DT, Savin VJ, Sharma M, Reiser J, Wei C, Somers M, Srivastava T, Gipson DS. Efficacy of galactose and adalimumab in patients with resistant focal segmental glomerulosclerosis: report of the font clinical trial group. BMC Nephrol. 2015 Jul 22; 16:111.
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Sharma M, Zhou J, Gauchat JF, Sharma R, McCarthy ET, Srivastava T, Savin VJ. Janus kinase 2/signal transducer and activator of transcription 3 inhibitors attenuate the effect of cardiotrophin-like cytokine factor 1 and human focal segmental glomerulosclerosis serum on glomerular filtration barrier. Transl Res. 2015 Oct; 166(4):384-98.
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