 Dose-Response Relationship, Drug
"Dose-Response Relationship, Drug" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the dose of an administered drug and the response of the organism to the drug.
| Descriptor ID |
D004305
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| MeSH Number(s) |
G07.690.773.875 G07.690.936.500
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| Concept/Terms |
Dose-Response Relationship, Drug- Dose-Response Relationship, Drug
- Dose-Response Relationships, Drug
- Drug Dose-Response Relationship
- Drug Dose-Response Relationships
- Relationship, Drug Dose-Response
- Relationships, Drug Dose-Response
- Dose Response Relationship, Drug
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Below are MeSH descriptors whose meaning is more general than "Dose-Response Relationship, Drug".
Below are MeSH descriptors whose meaning is more specific than "Dose-Response Relationship, Drug".
This graph shows the total number of publications written about "Dose-Response Relationship, Drug" by people in this website by year, and whether "Dose-Response Relationship, Drug" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 2 | 2 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 4 | 4 | | 2004 | 0 | 2 | 2 | | 2005 | 0 | 3 | 3 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 2 | 2 | | 2008 | 0 | 2 | 2 | | 2009 | 0 | 2 | 2 | | 2010 | 0 | 3 | 3 | | 2011 | 0 | 4 | 4 | | 2012 | 0 | 4 | 4 | | 2013 | 0 | 5 | 5 | | 2014 | 0 | 4 | 4 | | 2015 | 0 | 2 | 2 | | 2016 | 0 | 4 | 4 | | 2017 | 0 | 6 | 6 | | 2018 | 0 | 4 | 4 | | 2019 | 1 | 7 | 8 | | 2020 | 0 | 4 | 4 | | 2021 | 0 | 2 | 2 | | 2023 | 0 | 1 | 1 | | 2024 | 0 | 3 | 3 | | 2025 | 0 | 2 | 2 | | 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dose-Response Relationship, Drug" by people in Profiles.
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Gooden F, Meier BD, Shaffer GD, Gibson K, Toren P, Punt NC, Subash S, Singh DK, Prasad B, Ramsey LB, Taylor ZL. Pharmacogenetic hSLCO1B1*14-Guided Dosing of Methotrexate in Transgenic Arthritic Mice Normalizes Exposure and Response. Clin Transl Sci. 2026 Jan; 19(1):e70449.
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Shulman RJ, Chumpitazi BP, Gonzalez D, Garg U, Musaad S, Wen J, Kearns GL. Randomized trial: Peppermint oil (menthol) pharmacokinetics in children and effects on gut motility in children with functional abdominal pain: 540?mg vs. 900?mg dose comparison. Br J Clin Pharmacol. 2025 Sep; 91(9):2711-2724.
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Heldrup J, Bleyer A, Ramsey L, Schaff L, Bernhardt B, Schwartz S, Chatelut E, Hwang M, Ten C, Guscott M, Howard S. New recommendations for reversal of high-dose methotrexate cytotoxicity with folinic acid. Cancer Chemother Pharmacol. 2025 Mar 13; 95(1):41.
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Bishop JR, Zhou C, Gaedigk A, Krone B, Kittles R, Cook EH, Newcorn JH, Stein MA. Dopamine Transporter and CYP2D6 Gene Relationships with Attention-Deficit/Hyperactivity Disorder Treatment Response in the Methylphenidate and Atomoxetine Crossover Study. J Child Adolesc Psychopharmacol. 2024 12; 34(10):458-469.
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Christensen SR, Jensen CF, Heldrup J, Taylor Z, Ramsey LB, Rosth?j S. Hypoalbuminemia in children with acute lymphoblastic leukemia: relation to asparaginase therapy and impact on high dose methotrexate elimination. Cancer Chemother Pharmacol. 2024 Dec; 94(6):775-785.
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Morales Junior R, Amajor V, Paice K, Kyler KE, Hambrick HR, Pavia KE, Haynes AS, Gooden F, Pais GM, Downes KJ, Ramsey LB, Wagner J, Tang Girdwood S. From Dose to Exposure: Shifting the Paradigm of Pediatric Clinical Pharmacology Research and Education. Clin Pharmacol Ther. 2024 Sep; 116(3):515-517.
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Alghamdi A, Seay S, Hooper DK, Varnell CD, Darland L, Mizuno T, Lazear D, Ramsey LB. Tacrolimus pharmacokinetics are influenced by CYP3A5, age, and concomitant fluconazole in pediatric kidney transplant patients. Clin Transl Sci. 2023 10; 16(10):1768-1778.
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Hitzler J, Alonzo T, Gerbing R, Beckman A, Hirsch B, Raimondi S, Chisholm K, Viola S, Brodersen L, Loken M, Tong S, Druley T, O'Brien M, Hijiya N, Heerema-McKenney A, Wang YC, Schore R, Taub J, Gamis A, Kolb EA, Berman JN. High-dose AraC is essential for the treatment of ML-DS independent of postinduction MRD: results of the COG AAML1531 trial. Blood. 2021 12 09; 138(23):2337-2346.
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Downes KJ, Goldman JL. Too Much of a Good Thing: Defining Antimicrobial Therapeutic Targets to Minimize Toxicity. Clin Pharmacol Ther. 2021 04; 109(4):905-917.
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Vyhlidal CA, Chapron BD, Ahmed A, Singh V, Casini R, Shakhnovich V. Effect of Crohn's Disease on Villous Length and CYP3A4 Expression in the Pediatric Small Intestine. Clin Transl Sci. 2021 03; 14(2):729-736.
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