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Robert H. Lane, MD, MS

TitleExecutive Vice President/Physician-in-Chief
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gilham Rd
Kansas City MO 64108
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    Other Positions
    TitleResearch Professor
    InstitutionUniversity of Kansas Medical Center
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    University of Notre Dame, South Bend, INB.S.1985Pre-Professional Science
    Northwestern University Medical School, Chicago, ILM.D.1989Medicine
    Northwestern University Medical School, Chicago, ILResidency1992Pediatrics
    University of Chicago, Chicago, ILPost Doctoral1994Postdoctoral Training/Pediatrics Scientist Training Program
    Northwestern University Medical School, Chicago, ILFellowship1995Neonatal-Perinatal Medicine
    University of Texas at Dallas/University of Texas Southwestern, Richardson, TXM.S.2012Healthcare Administration
    Collapse awards and honors
    1989 - 1989Alpha Omega Alpha
    1992 - 1994Pediatric Scientist Training Fellowship Award
    1997 - 1997NIDDK-ONRC Pilot Study Award
    1997 - 1997NICHD-CNRC Junior Faculty Award
    1999 - 1999NICHD CIDA Award
    1999 - 1999MRRC New Program Development Award
    2001 - 2001Howard Hughes Prime Award
    2001 - 2001NICHD-CHRC Junior Faculty Award, UCLA
    2003 - 2003WSPR Ross Award for Young Investigators
    2012 - 2012Beta Gamma Sigma
    2011 - 2011President, Perinatal Research Society
    2015 - 2020AMSPDC Representative, AAP COPRE Committee
    2018 - 2020President, US Developmental Origins of Health Society
    2011 - 2011Co-Chair, NHLBI Workshop on Molecular Determinants of Lung Development
    2017 - 2017Fellow, AAMC Council of Deans
    2020Schellhorn Family Endowed Chair in Medical Administration, Children's Mercy

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    Dr. Lane’s research program focuses upon on how perinatal events affect in vivo epigenetic determinants of gene expression and lead to adult disease. In 1996, Dr. Lane published his first original science manuscript on this focus, and he has remained committed to the topic. Indeed, the vast majority of his > 90 publications are devoted to how perinatal events lead to adult disease. In 2003, Dr. Lane published his first original science manuscript on how perinatal events impact in vivo epigenetics. This study stands among the earliest to demonstrate that a perinatal event affected the epigenetics of a specific gene. Dr. Lane also has a track record of NIH funding as P.I. and a Co-I, the latter demonstrating his willingness to enthusiastically engage in team science. In 2013, Dr. Lane accepted the position of Pediatrician in Chief and Chair of Pediatrics at Children’s Hospital of Wisconsin. This move required Dr. Lane to move his laboratory. Yet, despite the move and the job requirements, Dr. Lane has maintained his scholarly productivity. In 2020, Dr. Lane accepted the position of Executive Vice President /Physician in Chief at Children’s Mercy in Kansas City. Dr. Lane has actively participated in the US Developmental Origins and Health and Disease Society. He has served as the scientific program officer for 2018 and 2019. In 2019, he was elected President of the Society. Dr. Lane’s laboratory has continued to be productive scientifically publishing papers in 2018 and 2019. Dr. Lane also chaired the NIH Social Epigenomics Study Section in 2020. His laboratory will move from Milwaukee to Kansas City in 6/2020 pending the impact of COVID-19.
    Collapse research activities and funding
         (LANE, ROBERT H)Jan 1, 1999 - Dec 1, 2003
    American Diabetes Association
    Increased Skeletal Muscle Expression of the Trifunctional Protein of Fatty Acid Oxidation Increases Insulin Resistance: A Model of Prenatal Metabolic Imprinting and Syndrome X
    Role Description: The goal of this study is to determine how uteroplacental insufficiency program skeletal muscle fatty acid metabolism.
    Role: Principal Investigator
    K08HD001225     (LANE, ROBERT H)Jan 1, 1999 - Jun 30, 2004
    NIH
    PLACENTAL INSUFFICIENCY ALTERS MITOCHONDRIAL FUNCTION
    Role: Principal Investigator
         (LANE, ROBERT H)Jan 1, 1999 - May 31, 2005
    March of Dimes
    Uteroplacental Insufficiency Alters DNA Methylation
    Role Description: The goal of this study was to determine the impact of uteroplacental insufficiency and IUGR upon DNA methylation
    Role: Principal Investigator
    R01HD041075     (LANE, ROBERT H)Apr 1, 2002 - Mar 31, 2007
    NIH
    Uteroplacental Insufficiency Alters DNA Methylation
    Role: Principal Investigator
    R01HD047013     (Cohen)Jul 1, 2004 - Jun 30, 2008
    NIH/NICHD
    IGF2 in Fetal Growth Restriction
    Role Description: The goal of this study is to determine the interaction between IGF2 and growth restriction.
    Role: Co-Investigator
    R01HL062875     (Albertine)Apr 1, 2005 - Mar 31, 2010
    NIH/NHLBI
    Vitamin A Effects on Alveolar Formation in Preterm and Fetal Lambs with Chronic Lung Diseae
    Role Description: The goal of this study is to determine the effects of maternal Vitamin A upon fetal lung development in the context of mechanical ventilation.
    Role: Co-Investigator
    R01DK060685     (Grove)Sep 20, 2006 - Apr 30, 2007
    NIH/NIDDK
    NPY Feeding Circuits During Development
    Role Description: The goal of this study is to study the molecular biology of NPY feeding circuits during development.
    Role: Co-Investigator
    R01DK080558     (LANE, ROBERT H)Jul 1, 2007 - Jun 30, 2012
    NIH
    Maternal Diet Modifies the Fetal Primate Epigenome and Circadian Gene Expression
    Role: Principal Investigator
    R01DK079194     (Grove)Jul 15, 2007 - May 31, 2011
    NIH/NIDDK
    Maternal High Fat Diet and Melanocortin System in Offspring
    Role Description: The goal of this study is to determine the effects of maternal high fat diet upon the molecular biology the melanocortin system and associate gene expression.
    Role: Co-Investigator
    DK081756     (Desai)Jul 1, 2010 - Jun 30, 2015
    NIH/NIDDK
    Programmed Adipogenesis and Lipid Dysregulation
    Role Description: The goal of this study is determine the effect of maternal diet on adipocyte programming.
    Role: Co-Invesigator
    K01DK084036     (Joss-Moore)Oct 1, 2010 - Sep 30, 2013
    NIH/NHLBI
    Epigenetic Modulation of the PPARgamma Transcription in the IUGR Rat
    Role Description: The goal of this study is to determine the impact of IUGR upon PPARgramma epigenetic and concurrent gene expression.
    Role: Mentor
    R01 HL110002     (Albertine)Jun 15, 2011 - May 31, 2016
    NIH/NHLBI
    Epigenetics Participate in Neonatal CLD
    Role Description: The goal of this study is to determine how mechanical ventilation affect developing lung pulmonary epigenetics.
    Role: Co-Investigator
    R01HL127237     (Rehan)Jan 1, 2016 - Dec 31, 2019
    NIH/NHLBI
    Developmental Nicotine Exposure and Transgenerationally Altered Lung Phenotype
    Role Description: The goal of this study is to determine the impact of prenatal nicotine upon progeny lung phenotype.
    Role: Co-Investigator

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Ke X, Huang Y, Fu Q, Majnik A, Sampath V, Lane RH. Adverse maternal environment alters Oprl1 variant expression in mouse hippocampus. Anat Rec (Hoboken). 2023 01; 306(1):162-175. PMID: 35983908.
      View in: PubMed
    2. Ke X, Huang Y, Fu Q, Majnik A, Lane RH. Adverse maternal environment affects hippocampal HTR2c variant expression and epigenetic characteristics in mouse offspring. Pediatr Res. 2022 11; 92(5):1299-1308. PMID: 35121849.
      View in: PubMed
    3. Lisa A. Joss-Moore Robert H. Lane Paul J. Rozance Ian Bird Kurt H. Albertine. Perinatal Research Society's Young Investigator Workshop Prepares the Next Generation of Investigators. Society for Reproductive Investigation Reproductive Sciences Maternal Fetal Medicine/Biology. 2021; 7.
      View Publication
    4. Fu Q, North PE, Ke X, Huang YW, Fritz KA, Majnik AV, Lane RH. Adverse Maternal Environment and Postweaning Western Diet Alter Hepatic CD36 Expression and Methylation Concurrently with Nonalcoholic Fatty Liver Disease in Mouse Offspring. J Nutr. 2021 10 01; 151(10):3102-3112. PMID: 34486661.
      View in: PubMed
    5. Ferguson BS, Wennersten SA, Demos-Davies KM, Rubino M, Robinson EL, Cavasin MA, Stratton MS, Kidger AM, Hu T, Keyse SM, McKnight RA, Lane RH, Nozik ES, Weiser-Evans MCM, McKinsey TA. DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy. Am J Physiol Heart Circ Physiol. 2021 08 01; 321(2):H382-H389. PMID: 34142888.
      View in: PubMed
    6. Ke X, Huang Y, Fu Q, Lane RH, Majnik A. Adverse Maternal Environment Alters MicroRNA-10b-5p Expression and Its Epigenetic Profile Concurrently with Impaired Hippocampal Neurogenesis in Male Mouse Hippocampus. Dev Neurosci. 2021; 43(2):95-105. PMID: 33940573.
      View in: PubMed
    7. Ke X, Huang Y, Fu Q, Lane RH, Majnik A. Adverse Maternal Environment Alters MicroRNA-10b-5p Expression and Its Epigenetic Profile Concurrently with Impaired Hippocampal Neurogenesis in Male Mouse Hippocampus. 2021.
    8. Ke X, Xing B, Dahl MJ, Alvord J, McKnight RA, Lane RH, Albertine KH. Hippocampal epigenetic and insulin-like growth factor alterations in noninvasive versus invasive mechanical ventilation in preterm lambs. Pediatr Res. 2021 11; 90(5):998-1008. PMID: 33603215.
      View in: PubMed
    9. Ke X, Fu Q, Sterrett J, Hillard CJ, Lane RH, Majnik A. Adverse maternal environment and western diet impairs cognitive function and alters hippocampal glucocorticoid receptor promoter methylation in male mice. Physiol Rep. 2020 04; 8(8):e14407. PMID: 32333646.
      View in: PubMed
    10. Lai PY, Jing X, Michalkiewicz T, Entringer B, Ke X, Majnik A, Kriegel AJ, Liu P, Lane RH, Konduri GG. Adverse early-life environment impairs postnatal lung development in mice. Physiol Genomics. 2019 09 01; 51(9):462-470. PMID: 31373541.
      View in: PubMed
    11. Spearman AD, Ke X, Fu Q, Lane RH, Majnik A. Adverse maternal environment leads to cardiac fibrosis in adult male mice. Birth Defects Res. 2018 12 01; 110(20):1551-1555. PMID: 30576090.
      View in: PubMed
    12. Ke X, Fu Q, Majnik A, Cohen S, Liu Q, Lane R. Adverse early life environment induces anxiety-like behavior and increases expression of FKBP5 mRNA splice variants in mouse brain. Physiol Genomics. 2018 11 01; 50(11):973-981. PMID: 30240345.
      View in: PubMed
    13. Ke X, Johnson H, Jing X, Michalkiewicz T, Huang YW, Lane RH, Konduri GG. Persistent pulmonary hypertension alters the epigenetic characteristics of endothelial nitric oxide synthase gene in pulmonary artery endothelial cells in a fetal lamb model. Physiol Genomics. 2018 10 01; 50(10):828-836. PMID: 30004838.
      View in: PubMed
    14. Habibian JS, Jefic M, Bagchi RA, Lane RH, McKnight RA, McKinsey TA, Morrison RF, Ferguson BS. DUSP5 functions as a feedback regulator of TNFa-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes. Sci Rep. 2017 10 10; 7(1):12879. PMID: 29018280.
      View in: PubMed
    15. Becker S, Wang H, Yu B, Brown R, Han X, Lane RH, Hartnett ME. Protective effect of maternal uteroplacental insufficiency on oxygen-induced retinopathy in offspring: removing bias of premature birth. Sci Rep. 2017 02 14; 7:42301. PMID: 28195189.
      View in: PubMed
    16. Cohen S, Ke X, Liu Q, Fu Q, Majnik A, Lane R. Adverse early life environment increases hippocampal microglia abundance in conjunction with decreased neural stem cells in juvenile mice. Int J Dev Neurosci. 2016 Dec; 55:56-65. PMID: 27666383.
      View in: PubMed
    17. Zinkhan EK, Zalla JM, Carpenter JR, Yu B, Yu X, Chan G, Joss-Moore L, Lane RH. Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol and low-density lipoprotein receptor activity in rats. Physiol Rep. 2016 Jul; 4(13). PMID: 27401460.
      View in: PubMed
    18. Majnik AV, Lane RH. The relationship between early-life environment, the epigenome and the microbiota. Epigenomics. 2015 Oct; 7(7):1173-84. PMID: 26585860.
      View in: PubMed
    19. McKnight RA, Yost CC, Yu X, Wiedmeier JE, Callaway CW, Brown AS, Lane RH, Fung CM. Intrauterine growth restriction perturbs nucleosome depletion at a growth hormone-responsive element in the mouse IGF-1 gene. Physiol Genomics. 2015 Dec; 47(12):634-43. PMID: 26487705.
      View in: PubMed
    20. Lewelt A, Krosschell KJ, Stoddard GJ, Weng C, Xue M, Marcus RL, Gappmaier E, Viollet L, Johnson BA, White AT, Viazzo-Trussell D, Lopes P, Lane RH, Carey JC, Swoboda KJ. Resistance strength training exercise in children with spinal muscular atrophy. Muscle Nerve. 2015 Oct; 52(4):559-67. PMID: 25597614.
      View in: PubMed
    21. Desai M, Jellyman JK, Han G, Lane RH, Ross MG. Programmed regulation of rat offspring adipogenic transcription factor (PPAR?) by maternal nutrition. J Dev Orig Health Dis. 2015 Dec; 6(6):530-8. PMID: 26286138.
      View in: PubMed
    22. Suter MA, Abramovici AR, Griffin E, Branch DW, Lane RH, Mastrobattista J, Rehan VK, Aagaard K. In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model. Birth Defects Res A Clin Mol Teratol. 2015 Jul; 103(7):583-8. PMID: 26172404.
      View in: PubMed
    23. Ke X, McKnight RA, Gracey Maniar LE, Sun Y, Callaway CW, Majnik A, Lane RH, Cohen SS. IUGR increases chromatin-remodeling factor Brg1 expression and binding to GR exon 1.7 promoter in newborn male rat hippocampus. Am J Physiol Regul Integr Comp Physiol. 2015 Jul 15; 309(2):R119-27. PMID: 25972460.
      View in: PubMed
    24. Fung CM, Yang Y, Fu Q, Brown AS, Yu B, Callaway CW, Li J, Lane RH, McKnight RA. IUGR prevents IGF-1 upregulation in juvenile male mice by perturbing postnatal IGF-1 chromatin remodeling. Pediatr Res. 2015 Jul; 78(1):14-23. PMID: 25826117.
      View in: PubMed
    25. Fu Q, McKnight RA, Callaway CW, Yu X, Lane RH, Majnik AV. Intrauterine growth restriction disrupts developmental epigenetics around distal growth hormone response elements on the rat hepatic IGF-1 gene. FASEB J. 2015 Apr; 29(4):1176-84. PMID: 25466885.
      View in: PubMed
    26. Goodspeed D, Seferovic MD, Holland W, Mcknight RA, Summers SA, Branch DW, Lane RH, Aagaard KM. Essential nutrient supplementation prevents heritable metabolic disease in multigenerational intrauterine growth-restricted rats. FASEB J. 2015 Mar; 29(3):807-19. PMID: 25395450.
      View in: PubMed
    27. Joss-Moore LA, Lane RH, Albertine KH. Epigenetic contributions to the developmental origins of adult lung disease. Biochem Cell Biol. 2015 Apr; 93(2):119-27. PMID: 25493710.
      View in: PubMed
    28. Lane RH. Fetal programming, epigenetics, and adult onset disease. Clin Perinatol. 2014 Dec; 41(4):815-31. PMID: 25459776.
      View in: PubMed
    29. Majnik A, Gunn V, Fu Q, Lane RH. Epigenetics: an accessible mechanism through which to track and respond to an obesogenic environment. Expert Rev Endocrinol Metab. 2014 Nov; 9(6):605-614. PMID: 30736198.
      View in: PubMed
    30. Zinkhan EK, Chin JR, Zalla JM, Yu B, Numpang B, Yu X, Jiang C, Callaway CW, McKnight RA, Joss-Moore L, Lane RH. Combination of intrauterine growth restriction and a high-fat diet impairs cholesterol elimination in rats. Pediatr Res. 2014 Nov; 76(5):432-40. PMID: 25119340.
      View in: PubMed
    31. Zinkhan EK, Lang BY, Yu B, Wang Y, Jiang C, Fitzhugh M, Dahl M, Campbell MS, Fung C, Malleske D, Albertine KH, Joss-Moore L, Lane RH. Maternal tobacco smoke increased visceral adiposity and serum corticosterone levels in adult male rat offspring. Pediatr Res. 2014 Jul; 76(1):17-23. PMID: 24727947.
      View in: PubMed
    32. Desai M, Jellyman JK, Han G, Beall M, Lane RH, Ross MG. Maternal obesity and high-fat diet program offspring metabolic syndrome. Am J Obstet Gynecol. 2014 Sep; 211(3):237.e1-237.e13. PMID: 24631702.
      View in: PubMed
    33. Schober ME, Requena DF, Block B, Davis LJ, Rodesch C, Casper TC, Juul SE, Kesner RP, Lane RH. Erythropoietin improved cognitive function and decreased hippocampal caspase activity in rat pups after traumatic brain injury. J Neurotrauma. 2014 Feb 15; 31(4):358-69. PMID: 23972011.
      View in: PubMed
    34. Majnik AV, Lane RH. Epigenetics: where environment, society and genetics meet. Epigenomics. 2014 Feb; 6(1):1-4. PMID: 24579939.
      View in: PubMed
    35. Null DM, Alvord J, Leavitt W, Wint A, Dahl MJ, Presson AP, Lane RH, DiGeronimo RJ, Yoder BA, Albertine KH. High-frequency nasal ventilation for 21 d maintains gas exchange with lower respiratory pressures and promotes alveolarization in preterm lambs. Pediatr Res. 2014 Apr; 75(4):507-16. PMID: 24378898.
      View in: PubMed
    36. O'Neil D, Mendez-Figueroa H, Mistretta TA, Su C, Lane RH, Aagaard KM. Dysregulation of Npas2 leads to altered metabolic pathways in a murine knockout model. Mol Genet Metab. 2013 Nov; 110(3):378-87. PMID: 24067359.
      View in: PubMed
    37. Osborne-Majnik A, Fu Q, Lane RH. Epigenetic mechanisms in fetal origins of health and disease. Clin Obstet Gynecol. 2013 Sep; 56(3):622-32. PMID: 23787712.
      View in: PubMed
    38. Hartnett ME, Lane RH. Effects of oxygen on the development and severity of retinopathy of prematurity. J AAPOS. 2013 Jun; 17(3):229-34. PMID: 23791404.
      View in: PubMed
    39. Grimes CE, Maraka J, Kingsnorth AN, Darko R, Samkange CA, Lane RH. Guidelines for surgeons on establishing projects in low-income countries. World J Surg. 2013 Jun; 37(6):1203-7. PMID: 23474858.
      View in: PubMed
    40. Numpang B, Ke X, Yu X, Callaway C, McKnight R, Joss-Moore L, Lane R. Fetal growth restriction alters hippocampal 17-beta estradiol and estrogen receptor alpha levels in the newborn male rat. Syst Biol Reprod Med. 2013 Aug; 59(4):184-90. PMID: 23631676.
      View in: PubMed
    41. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. PMID: 23607856.
      View in: PubMed
    42. Bagley HN, Wang Y, Campbell MS, Yu X, Lane RH, Joss-Moore LA. Maternal docosahexaenoic acid increases adiponectin and normalizes IUGR-induced changes in rat adipose deposition. J Obes. 2013; 2013:312153. PMID: 23533720.
      View in: PubMed
    43. Joss-Moore L, Carroll T, Yang Y, Fitzhugh M, Metcalfe D, Oman J, Hale M, Dong L, Wang ZM, Yu X, Callaway CW, O'Brien E, McKnight RA, Lane RH, Albertine KH. Intrauterine growth restriction transiently delays alveolar formation and disrupts retinoic acid receptor expression in the lung of female rat pups. Pediatr Res. 2013 May; 73(5):612-620. PMID: 23419538.
      View in: PubMed
    44. Haley S, Neff K, Gulliver K, Gough G, Slater H, Lane RH, Moyer-Mileur LJ. Mechanical-tactile stimulation (MTS) intervention in a neonatal stress model alters adult adipose tissue deposition and prevents hyperinsulinemia in male rats. Early Hum Dev. 2013 Jun; 89(6):387-92. PMID: 23290636.
      View in: PubMed
    45. Joss-Moore LA, Lane RH. Epigenetics and the developmental origins of disease: the key to unlocking the door of personalized medicine. Epigenomics. 2012 Oct; 4(5):471-3. PMID: 23130826.
      View in: PubMed
    46. Suter MA, Sangi-Haghpeykar H, Showalter L, Shope C, Hu M, Brown K, Williams S, Harris RA, Grove KL, Lane RH, Aagaard KM. Maternal high-fat diet modulates the fetal thyroid axis and thyroid gene expression in a nonhuman primate model. Mol Endocrinol. 2012 Dec; 26(12):2071-80. PMID: 23015752.
      View in: PubMed
    47. Suter MA, Chen A, Burdine MS, Choudhury M, Harris RA, Lane RH, Friedman JE, Grove KL, Tackett AJ, Aagaard KM. A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. FASEB J. 2012 Dec; 26(12):5106-14. PMID: 22982377.
      View in: PubMed
    48. Chen H, Miller S, Lane RH, Moyer-Mileur LJ. Intrauterine growth restriction decreases endochondral ossification and bone strength in female rats. Am J Perinatol. 2013 Apr; 30(4):261-6. PMID: 22875655.
      View in: PubMed
    49. Yee JK, Lee WN, Ross MG, Lane RH, Han G, Vega J, Desai M. Peroxisome proliferator-activated receptor gamma modulation and lipogenic response in adipocytes of small-for-gestational age offspring. Nutr Metab (Lond). 2012 Jun 22; 9(1):62. PMID: 22726273.
      View in: PubMed
    50. Boekelheide K, Blumberg B, Chapin RE, Cote I, Graziano JH, Janesick A, Lane R, Lillycrop K, Myatt L, States JC, Thayer KA, Waalkes MP, Rogers JM. Predicting later-life outcomes of early-life exposures. Environ Health Perspect. 2012 Oct; 120(10):1353-61. PMID: 22672778.
      View in: PubMed
    51. Schober ME, Block B, Requena DF, Hale MA, Lane RH. Developmental traumatic brain injury decreased brain derived neurotrophic factor expression late after injury. Metab Brain Dis. 2012 Jun; 27(2):167-73. PMID: 22527999.
      View in: PubMed
    52. Schober ME, Ke X, Xing B, Block BP, Requena DF, McKnight R, Lane RH. Traumatic brain injury increased IGF-1B mRNA and altered IGF-1 exon 5 and promoter region epigenetic characteristics in the rat pup hippocampus. J Neurotrauma. 2012 Jul 20; 29(11):2075-85. PMID: 22413999.
      View in: PubMed
    53. Zinkhan EK, Fu Q, Wang Y, Yu X, Callaway CW, Segar JL, Scholz TD, McKnight RA, Joss-Moore L, Lane RH. Maternal Hyperglycemia Disrupts Histone 3 Lysine 36 Trimethylation of the IGF-1 Gene. J Nutr Metab. 2012; 2012:930364. PMID: 22548154.
      View in: PubMed
    54. Caprau D, Schober ME, Bass K, O'Grady S, Ke X, Block B, Callaway CW, Hale M, Yu X, McKnight RA, Kesner RP, Lane RH. Altered expression and chromatin structure of the hippocampal IGF1r gene is associated with impaired hippocampal function in the adult IUGR male rat. J Dev Orig Health Dis. 2012 Apr; 3(2):83-91. PMID: 25101918.
      View in: PubMed
    55. Fung C, Ke X, Brown AS, Yu X, McKnight RA, Lane RH. Uteroplacental insufficiency alters rat hippocampal cellular phenotype in conjunction with ErbB receptor expression. Pediatr Res. 2012 Jul; 72(1):2-9. PMID: 22367251.
      View in: PubMed
    56. Rehan VK, Fong J, Lee R, Sakurai R, Wang ZM, Dahl MJ, Lane RH, Albertine KH, Torday JS. Mechanism of reduced lung injury by high-frequency nasal ventilation in a preterm lamb model of neonatal chronic lung disease. Pediatr Res. 2011 Nov; 70(5):462-6. PMID: 21814155.
      View in: PubMed
    57. Haley S, O'Grady S, Gulliver K, Bowman B, Baldassarre R, Miller S, Lane RH, Moyer-Mileur LJ. Mechanical-tactile stimulation (MTS) intervention in a neonatal stress model improves long-term outcomes on bone. J Musculoskelet Neuronal Interact. 2011 Sep; 11(3):234-42. PMID: 21885898.
      View in: PubMed
    58. Ke X, McKnight RA, Caprau D, O'Grady S, Fu Q, Yu X, Callaway CW, Albertine KH, Lane RH. Intrauterine growth restriction affects hippocampal dual specificity phosphatase 5 gene expression and epigenetic characteristics. Physiol Genomics. 2011 Oct 20; 43(20):1160-9. PMID: 21828247.
      View in: PubMed
    59. Contreras YM, Yu X, Hale MA, Callaway CW, Bareyan D, McKnight RA, Joss-Moore LA, Enioutina EY, Lane RH. Intrauterine growth restriction alters T-lymphocyte cell number and dual specificity phosphatase 1 levels in the thymus of newborn and juvenile rats. Pediatr Res. 2011 Aug; 70(2):123-9. PMID: 21505375.
      View in: PubMed
    60. Joss-Moore LA, Albertine KH, Lane RH. Epigenetics and the developmental origins of lung disease. Mol Genet Metab. 2011 Sep-Oct; 104(1-2):61-6. PMID: 21835665.
      View in: PubMed
    61. Joss-Moore LA, Wang Y, Ogata EM, Sainz AJ, Yu X, Callaway CW, McKnight RA, Albertine KH, Lane RH. IUGR differentially alters MeCP2 expression and H3K9Me3 of the PPAR? gene in male and female rat lungs during alveolarization. Birth Defects Res A Clin Mol Teratol. 2011 Aug; 91(8):672-81. PMID: 21425435.
      View in: PubMed
    62. Joss-Moore LA, Wang Y, Yu X, Campbell MS, Callaway CW, McKnight RA, Wint A, Dahl MJ, Dull RO, Albertine KH, Lane RH. IUGR decreases elastin mRNA expression in the developing rat lung and alters elastin content and lung compliance in the mature rat lung. Physiol Genomics. 2011 May 13; 43(9):499-505. PMID: 21363967.
      View in: PubMed
    63. Wiedmeier JE, Joss-Moore LA, Lane RH, Neu J. Early postnatal nutrition and programming of the preterm neonate. Nutr Rev. 2011 Feb; 69(2):76-82. PMID: 21294741.
      View in: PubMed
    64. Moyer-Mileur LJ, Haley S, Gulliver K, Thomson A, Slater H, Barrett B, Joss-Moore LA, Callaway C, McKnight RA, Moore B, Lane RH. Mechanical-tactile stimulation (MTS) during neonatal stress prevents hyperinsulinemia despite stress-induced adiposity in weanling rat pups. Early Hum Dev. 2011 Mar; 87(3):159-63. PMID: 21211914.
      View in: PubMed
    65. Schober ME, Block B, Beachy JC, Statler KD, Giza CC, Lane RH. Early and sustained increase in the expression of hippocampal IGF-1, but not EPO, in a developmental rodent model of traumatic brain injury. J Neurotrauma. 2010 Nov; 27(11):2011-20. PMID: 20822461.
      View in: PubMed
    66. Joss-Moore LA, Wang Y, Baack ML, Yao J, Norris AW, Yu X, Callaway CW, McKnight RA, Albertine KH, Lane RH. IUGR decreases PPAR? and SETD8 Expression in neonatal rat lung and these effects are ameliorated by maternal DHA supplementation. Early Hum Dev. 2010 Dec; 86(12):785-91. PMID: 20869820.
      View in: PubMed
    67. Tosh DN, Fu Q, Callaway CW, McKnight RA, McMillen IC, Ross MG, Lane RH, Desai M. Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth. Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1023-9. PMID: 20813916.
      View in: PubMed
    68. O'Grady SP, Caprau D, Ke XR, Contreras Y, Haley S, Ermini F, Penn A, Moyer-Mileur L, McKnight R, Lane R. Intrauterine growth restriction alters hippocampal expression and chromatin structure of Cyp19a1 variants. Syst Biol Reprod Med. 2010 Aug; 56(4):292-302. PMID: 20662593.
      View in: PubMed
    69. McKnight RA, Joss-Moore LA, Lane RH. Stem cell DNA methylation: a consequence of intrauterine growth restriction. Epigenomics. 2010 Jun; 2(3):359-60. PMID: 22121897.
      View in: PubMed
    70. McKnight RA, Joss-Moore LA, Lane RH. Intrauterine growth restriction, neural microRNA expression and hypertension in the mouse. Epigenomics. 2010 Jun; 2(3):360-1. PMID: 22232785.
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    71. McKnight RA, Joss-Moore LA, Lane RH. Placental variability in methylation reflects maternal and fetal pathogenesis. Epigenomics. 2010 Jun; 2(3):362-3. PMID: 22232786.
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    72. McKnight RA, Joss-Moore LA, Lane RH. Intrauterine growth restriction disturbs mediators of placental protein turnover. Epigenomics. 2010 Jun; 2(3):363-4. PMID: 22232787.
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    73. Baserga M, Kaur R, Hale MA, Bares A, Yu X, Callaway CW, McKnight RA, Lane RH. Fetal growth restriction alters transcription factor binding and epigenetic mechanisms of renal 11beta-hydroxysteroid dehydrogenase type 2 in a sex-specific manner. Am J Physiol Regul Integr Comp Physiol. 2010 Jul; 299(1):R334-42. PMID: 20427719.
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    74. Ke X, Schober ME, McKnight RA, O'Grady S, Caprau D, Yu X, Callaway CW, Lane RH. Intrauterine growth retardation affects expression and epigenetic characteristics of the rat hippocampal glucocorticoid receptor gene. Physiol Genomics. 2010 Jul 07; 42(2):177-89. PMID: 20388836.
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    75. Joss-Moore LA, Wang Y, Campbell MS, Moore B, Yu X, Callaway CW, McKnight RA, Desai M, Moyer-Mileur LJ, Lane RH. Uteroplacental insufficiency increases visceral adiposity and visceral adipose PPARgamma2 expression in male rat offspring prior to the onset of obesity. Early Hum Dev. 2010 Mar; 86(3):179-85. PMID: 20227202.
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    76. Joss-Moore LA, Metcalfe DB, Albertine KH, McKnight RA, Lane RH. Epigenetics and fetal adaptation to perinatal events: diversity through fidelity. J Anim Sci. 2010 Apr; 88(13 Suppl):E216-22. PMID: 19854998.
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    77. Cox J, Williams S, Grove K, Lane RH, Aagaard-Tillery KM. A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome. Am J Obstet Gynecol. 2009 Sep; 201(3):281.e1-9. PMID: 19733280.
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    78. Fu Q, Yu X, Callaway CW, Lane RH, McKnight RA. Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene. FASEB J. 2009 Aug; 23(8):2438-49. PMID: 19364764.
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    79. Joss-Moore LA, Lane RH. The developmental origins of adult disease. Curr Opin Pediatr. 2009 Apr; 21(2):230-4. PMID: 19663040.
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    80. Baserga M, Bares AL, Hale MA, Callaway CW, McKnight RA, Lane PH, Lane RH. Uteroplacental insufficiency affects kidney VEGF expression in a model of IUGR with compensatory glomerular hypertrophy and hypertension. Early Hum Dev. 2009 Jun; 85(6):361-7. PMID: 19188030.
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    81. Schober ME, McKnight RA, Yu X, Callaway CW, Ke X, Lane RH. Intrauterine growth restriction due to uteroplacental insufficiency decreased white matter and altered NMDAR subunit composition in juvenile rat hippocampi. Am J Physiol Regul Integr Comp Physiol. 2009 Mar; 296(3):R681-92. PMID: 19144756.
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    82. Desai M, Ferelli M, Kallichanda N, Lane RH. Programmed upregulation of adipogenic transcription factors in intrauterine growth-restricted offspring. Reprod Sci. 2008 Oct; 15(8):785-96. PMID: 19017816.
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    83. Reyburn B, Li M, Metcalfe DB, Kroll NJ, Alvord J, Wint A, Dahl MJ, Sun J, Dong L, Wang ZM, Callaway C, McKnight RA, Moyer-Mileur L, Yoder BA, Null DM, Lane RH, Albertine KH. Nasal ventilation alters mesenchymal cell turnover and improves alveolarization in preterm lambs. Am J Respir Crit Care Med. 2008 Aug 15; 178(4):407-18. PMID: 18556628.
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    84. Aagaard-Tillery KM, Grove K, Bishop J, Ke X, Fu Q, McKnight R, Lane RH. Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. J Mol Endocrinol. 2008 Aug; 41(2):91-102. PMID: 18515302.
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    85. Lane R. Mentoring and the development of the physician-scientist. J Pediatr. 2008 Feb; 152(2):296-7. PMID: 18206711.
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    86. Aagaard-Tillery KM, Porter TF, Lane RH, Varner MW, Lacoursiere DY. In utero tobacco exposure is associated with modified effects of maternal factors on fetal growth. Am J Obstet Gynecol. 2008 Jan; 198(1):66.e1-6. PMID: 18166310.
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    87. O'Brien EA, Barnes V, Zhao L, McKnight RA, Yu X, Callaway CW, Wang L, Sun JC, Dahl MJ, Wint A, Wang Z, McIntyre TM, Albertine KH, Lane RH. Uteroplacental insufficiency decreases p53 serine-15 phosphorylation in term IUGR rat lungs. Am J Physiol Regul Integr Comp Physiol. 2007 Jul; 293(1):R314-22. PMID: 17428897.
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    88. Ross MG, Desai M, Khorram O, McKnight RA, Lane RH, Torday J. Gestational programming of offspring obesity: a potential contributor to Alzheimer's disease. Curr Alzheimer Res. 2007 Apr; 4(2):213-7. PMID: 17430249.
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    89. Baserga M, Hale MA, Wang ZM, Yu X, Callaway CW, McKnight RA, Lane RH. Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension. Am J Physiol Regul Integr Comp Physiol. 2007 May; 292(5):R1943-55. PMID: 17272666.
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    90. Fu Q, McKnight RA, Yu X, Callaway CW, Lane RH. Growth retardation alters the epigenetic characteristics of hepatic dual specificity phosphatase 5. FASEB J. 2006 Oct; 20(12):2127-9. PMID: 16940436.
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    91. Ward RM, Lane RH, Albertine KH. Basic and translational research in neonatal pharmacology. J Perinatol. 2006 Jul; 26 Suppl 2:S8-S12. PMID: 16801973.
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    92. Baserga M, Hale MA, Ke X, Wang ZM, Yu X, Callaway CW, McKnight RA, Lane RH. Uteroplacental insufficiency increases p53 phosphorylation without triggering the p53-MDM2 functional circuit response in the IUGR rat kidney. Am J Physiol Regul Integr Comp Physiol. 2006 Aug; 291(2):R412-8. PMID: 16914427.
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    93. Ke X, Lei Q, James SJ, Kelleher SL, Melnyk S, Jernigan S, Yu X, Wang L, Callaway CW, Gill G, Chan GM, Albertine KH, McKnight RA, Lane RH. Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats. Physiol Genomics. 2006 Mar 13; 25(1):16-28. PMID: 16380407.
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    94. Baserga M, Hale MA, McKnight RA, Yu X, Callaway CW, Lane RH. Uteroplacental insufficiency alters hepatic expression, phosphorylation, and activity of the glucocorticoid receptor in fetal IUGR rats. Am J Physiol Regul Integr Comp Physiol. 2005 Nov; 289(5):R1348-53. PMID: 16002560.
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    95. Ke X, McKnight RA, Wang ZM, Yu X, Wang L, Callaway CW, Albertine KH, Lane RH. Nonresponsiveness of cerebral p53-MDM2 functional circuit in newborn rat pups rendered IUGR via uteroplacental insufficiency. Am J Physiol Regul Integr Comp Physiol. 2005 Apr; 288(4):R1038-45. PMID: 15563574.
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    96. Clark JA, Lane RH, Maclennan NK, Holubec H, Dvorakova K, Halpern MD, Williams CS, Payne CM, Dvorak B. Epidermal growth factor reduces intestinal apoptosis in an experimental model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2005 Apr; 288(4):G755-62. PMID: 15528252.
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    97. Fu Q, McKnight RA, Yu X, Wang L, Callaway CW, Lane RH. Uteroplacental insufficiency induces site-specific changes in histone H3 covalent modifications and affects DNA-histone H3 positioning in day 0 IUGR rat liver. Physiol Genomics. 2004 Dec 15; 20(1):108-16. PMID: 15494474.
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    98. Baserga M, Bertolotto C, Maclennan NK, Hsu JL, Pham T, Laksana GS, Lane RH. Uteroplacental insufficiency decreases small intestine growth and alters apoptotic homeostasis in term intrauterine growth retarded rats. Early Hum Dev. 2004 Sep; 79(2):93-105. PMID: 15324990.
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    99. MacLennan NK, James SJ, Melnyk S, Piroozi A, Jernigan S, Hsu JL, Janke SM, Pham TD, Lane RH. Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats. Physiol Genomics. 2004 Jun 17; 18(1):43-50. PMID: 15084713.
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    100. Pham TD, MacLennan NK, Chiu CT, Laksana GS, Hsu JL, Lane RH. Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney. Am J Physiol Regul Integr Comp Physiol. 2003 Nov; 285(5):R962-70. PMID: 12869365.
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    101. Lane RH, Maclennan NK, Daood MJ, Hsu JL, Janke SM, Pham TD, Puri AR, Watchko JF. IUGR alters postnatal rat skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a fiber specific manner. Pediatr Res. 2003 Jun; 53(6):994-1000. PMID: 12646730.
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    102. Lane RH, Dvorak B, MacLennan NK, Dvorakova K, Halpern MD, Pham TD, Philipps AF. IGF alters jejunal glucose transporter expression and serum glucose levels in immature rats. Am J Physiol Regul Integr Comp Physiol. 2002 Dec; 283(6):R1450-60. PMID: 12388463.
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    103. Lane RH, MacLennan NK, Hsu JL, Janke SM, Pham TD. Increased hepatic peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a rat model of intrauterine growth retardation and subsequent insulin resistance. Endocrinology. 2002 Jul; 143(7):2486-90. PMID: 12072378.
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    104. Tsai CE, Daood MJ, Lane RH, Hansen TW, Gruetzmacher EM, Watchko JF. P-glycoprotein expression in mouse brain increases with maturation. Biol Neonate. 2002 Jan; 81(1):58-64. PMID: 11803178.
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    105. Kloesz JL, Serdikoff CM, Maclennan NK, Adibi SA, Lane RH. Uteroplacental insufficiency alters liver and skeletal muscle branched-chain amino acid metabolism in intrauterine growth-restricted fetal rats. Pediatr Res. 2001 Nov; 50(5):604-10. PMID: 11641455.
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    106. Lane RH, Kelley DE, Ritov VH, Tsirka AE, Gruetzmacher EM. Altered expression and function of mitochondrial beta-oxidation enzymes in juvenile intrauterine-growth-retarded rat skeletal muscle. Pediatr Res. 2001 Jul; 50(1):83-90. PMID: 11420423.
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    107. Tsirka AE, Gruetzmacher EM, Kelley DE, Ritov VH, Devaskar SU, Lane RH. Myocardial gene expression of glucose transporter 1 and glucose transporter 4 in response to uteroplacental insufficiency in the rat. J Endocrinol. 2001 May; 169(2):373-80. PMID: 11312153.
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    108. Lane RH, Ramirez RJ, Tsirka AE, Kloesz JL, McLaughlin MK, Gruetzmacher EM, Devaskar SU. Uteroplacental insufficiency lowers the threshold towards hypoxia-induced cerebral apoptosis in growth-retarded fetal rats. Brain Res. 2001 Mar 23; 895(1-2):186-93. PMID: 11259777.
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    109. Lane RH, Kelley DE, Gruetzmacher EM, Devaskar SU. Uteroplacental insufficiency alters hepatic fatty acid-metabolizing enzymes in juvenile and adult rats. Am J Physiol Regul Integr Comp Physiol. 2001 Jan; 280(1):R183-90. PMID: 11124150.
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    110. Lane RH, Tsirka AE, Gruetzmacher EM. Uteroplacental insufficiency alters cerebral mitochondrial gene expression and DNA in fetal and juvenile rats. Pediatr Res. 2000 Jun; 47(6):792-7. PMID: 10832740.
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    111. Reid GJ, Lane RH, Flozak AS, Simmons RA. Placental expression of glucose transporter proteins 1 and 3 in growth-restricted fetal rats. Am J Obstet Gynecol. 1999 Apr; 180(4):1017-23. PMID: 10203672.
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    112. Lane RH, Crawford SE, Flozak AS, Simmons RA. Localization and quantification of glucose transporters in liver of growth-retarded fetal and neonatal rats. Am J Physiol. 1999 01; 276(1):E135-42. PMID: 9886959.
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    113. Lane RH, Chandorkar AK, Flozak AS, Simmons RA. Intrauterine growth retardation alters mitochondrial gene expression and function in fetal and juvenile rat skeletal muscle. Pediatr Res. 1998 May; 43(5):563-70. PMID: 9585000.
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    114. Lane RH, Flozak AS, Simmons RA. Measurement of GLUT mRNA in liver of fetal and neonatal rats using a novel method of quantitative polymerase chain reaction. Biochem Mol Med. 1996 Dec; 59(2):192-9. PMID: 8986644.
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    115. Lane RH, Flozak AS, Ogata ES, Bell GI, Simmons RA. Altered hepatic gene expression of enzymes involved in energy metabolism in the growth-retarded fetal rat. Pediatr Res. 1996 Mar; 39(3):390-4. PMID: 8929856.
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