Jean C. Dinh, PharmD, PhD
Title | Research Faculty PhD |
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Institution | Children's Mercy Kansas City |
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Department | Pediatrics |
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Address | 2401 Gillham Rd Kansas City MO 64108
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ORCID
.gif) | 0000-0003-3255-8925  |
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vCard | Download vCard |
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Title | Research Assistant Professor |
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Institution | University of Missouri-Kansas City |
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Department | Pediatrics |
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Biography University of Washington, School of Pharmacy, Seattle, WA | PharmD | 2009 | Pharmacy | University of Washington, School of Pharmacy, Seattle, WA | PhD | 2014 | Medicinal Chemistry | T32 Pediatric Clinical Pharmacology Fellows, Kansas City, MO | | 2019 | Pediatric Clinical Pharmacology |
2017 | Presidential Trainee Award, ASCPT | 2017 | Top Trainee Poster, ASCPT | 2015 | Jack Metcoff Award for Outstanding Resident or Fellow Research, Midwest Society for Pediatric Research |
Overview Research Dr. Dinh completed a dual doctoral program at the University of Washington in pharmacy and medicinal chemistry. As a graduate student, Dr. Dinh studied how point mutations in Cytochrome P450 2B6 could lead to alterations in drug metabolism of cyclophosphamide and methadone. She then went on to complete a T32 Pediatric Clinical Pharmacology Fellowship at Children’s Mercy Hospital. Here, Dr. Dinh has focused on completing the studies and experiments that serve as the foundation for a decision support tool for atomoxetine and conducting and leading clinical studies that enrolled children with attention deficit/hyperactivity disorder (ADHD).
U54HD090258 (LEEDER, JAMES STEVEN)Sep 23, 2016 - Jun 30, 2021 NIH Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids Role: Co-Investigator |
Bibliography
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Chapron BD, Dinh JC, Toren PC, Gaedigk A, Leeder JS. The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites. Drug Metab Dispos. 2020 Nov; 48(11):1113-1120. PMID: 32847865.
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Dinh JC, Hosey-Cojocari CM, Jones BL. Pediatric Clinical Endpoint and Pharmacodynamic Biomarkers: Limitations and Opportunities. Paediatr Drugs. 2020 Feb; 22(1):55-71. PMID: 31916200.
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Brown JT, Bishop JR, Sangkuhl K, Nurmi EL, Mueller DJ, Dinh JC, Gaedigk A, Klein TE, Caudle KE, McCracken JT, de Leon J, Leeder JS. Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy. Clin Pharmacol Ther. 2019 07; 106(1):94-102. PMID: 30801677.
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Sandritter TL, Dinh JC, Wagner JA, Lowry JA. Description of an Innovative Pediatric Individualized Therapeutics Clinic: Working toward Precision Drug Therapy. Children (Basel). 2019 Feb 25; 6(2). PMID: 30823616.
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Gaedigk A, Dinh JC, Jeong H, Prasad B, Leeder JS. Ten Years' Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics. J Pers Med. 2018 Apr 17; 8(2). PMID: 29673183.
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Dinh JC, Pearce RE, Van Haandel L, Gaedigk A, Leeder JS. Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children. Drug Metab Dispos. 2016 07; 44(7):1070-9. PMID: 27052878.
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Lewis T, Dinh J, Leeder JS. Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research. Clin Pharmacol Ther. 2015 Sep; 98(3):309-20. PMID: 26058918.
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Raccor BS, Claessens AJ, Dinh JC, Park JR, Hawkins DS, Thomas SS, Makar KW, McCune JS, Totah RA. Potential contribution of cytochrome P450 2B6 to hepatic 4-hydroxycyclophosphamide formation in vitro and in vivo. Drug Metab Dispos. 2012 Jan; 40(1):54-63. PMID: 21976622.
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2011 | 1 | 2015 | 1 | 2016 | 1 | 2018 | 1 | 2019 | 2 | 2020 | 2 |
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