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Jean C. Dinh, PharmD, PhD

TitleResearch Faculty PhD
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
ORCID ORCID Icon0000-0003-3255-8925 Additional info
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    Other Positions
    TitleResearch Assistant Professor
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    University of Washington, School of Pharmacy, Seattle, WAPharmD2009Pharmacy
    University of Washington, School of Pharmacy, Seattle, WAPhD2014Medicinal Chemistry
    T32 Pediatric Clinical Pharmacology Fellows, Kansas City, MO2019Pediatric Clinical Pharmacology
    Collapse awards and honors
    2017Presidential Trainee Award, ASCPT
    2017Top Trainee Poster, ASCPT
    2015Jack Metcoff Award for Outstanding Resident or Fellow Research, Midwest Society for Pediatric Research

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    Dr. Dinh completed a dual doctoral program at the University of Washington in pharmacy and medicinal chemistry. As a graduate student, Dr. Dinh studied how point mutations in Cytochrome P450 2B6 could lead to alterations in drug metabolism of cyclophosphamide and methadone. She then went on to complete a T32 Pediatric Clinical Pharmacology Fellowship at Children’s Mercy Hospital. Here, Dr. Dinh has focused on completing the studies and experiments that serve as the foundation for a decision support tool for atomoxetine and conducting and leading clinical studies that enrolled children with attention deficit/hyperactivity disorder (ADHD).
    Collapse research activities and funding
    U54HD090258     (LEEDER, JAMES STEVEN)Sep 23, 2016 - Jun 30, 2021
    NIH
    Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
    Role: Co-Investigator

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Dinh JC, Hosey-Cojocari CM, Jones BL. Pediatric Clinical Endpoint and Pharmacodynamic Biomarkers: Limitations and Opportunities. Paediatr Drugs. 2020 Feb; 22(1):55-71. PMID: 31916200.
      View in: PubMed
    2. Brown JT, Bishop JR, Sangkuhl K, Nurmi EL, Mueller DJ, Dinh JC, Gaedigk A, Klein TE, Caudle KE, McCracken JT, de Leon J, Leeder JS. Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy. Clin Pharmacol Ther. 2019 07; 106(1):94-102. PMID: 30801677.
      View in: PubMed
    3. Sandritter TL, Dinh JC, Wagner JA, Lowry JA. Description of an Innovative Pediatric Individualized Therapeutics Clinic: Working toward Precision Drug Therapy. Children (Basel). 2019 Feb 25; 6(2). PMID: 30823616.
      View in: PubMed
    4. Gaedigk A, Dinh JC, Jeong H, Prasad B, Leeder JS. Ten Years' Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics. J Pers Med. 2018 Apr 17; 8(2). PMID: 29673183.
      View in: PubMed
    5. Dinh JC, Pearce RE, Van Haandel L, Gaedigk A, Leeder JS. Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children. Drug Metab Dispos. 2016 07; 44(7):1070-9. PMID: 27052878.
      View in: PubMed
    6. Lewis T, Dinh J, Leeder JS. Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research. Clin Pharmacol Ther. 2015 Sep; 98(3):309-20. PMID: 26058918.
      View in: PubMed
    7. Raccor BS, Claessens AJ, Dinh JC, Park JR, Hawkins DS, Thomas SS, Makar KW, McCune JS, Totah RA. Potential contribution of cytochrome P450 2B6 to hepatic 4-hydroxycyclophosphamide formation in vitro and in vivo. Drug Metab Dispos. 2012 Jan; 40(1):54-63. PMID: 21976622.
      View in: PubMed
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